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1.
Rajesh P. Rastogi Richa Rajeshwar P. Sinha Shailendra P. Singh Donat-P. Häder 《Journal of industrial microbiology & biotechnology》2010,37(6):537-558
The substantial loss in the stratospheric ozone layer and consequent increase in solar ultraviolet radiation on the earth’s
surface have augmented the interest in searching for natural photoprotective compounds in organisms of marine as well as freshwater
ecosystems. A number of photoprotective compounds such as mycosporine-like amino acids (MAAs), scytonemin, carotenoids and
several other UV-absorbing substances of unknown chemical structure have been identified from different organisms. MAAs form
the most common class of UV-absorbing compounds known to occur widely in various marine organisms; however, several compounds
having UV-screening properties still need to be identified. The synthesis of scytonemin, a predominant UV-A-photoprotective
pigment, is exclusively reported in cyanobacteria. Carotenoids are important components of the photosynthetic apparatus that
serve both light-harvesting and photoprotective functions, either by direct quenching of the singlet oxygen or other toxic
reactive oxygen species or by dissipating the excess energy in the photosynthetic apparatus. The production of photoprotective
compounds is affected by several environmental factors such as different wavelengths of UVR, desiccation, nutrients, salt
concentration, light as well as dark period, and still there is controversy about the biosynthesis of various photoprotective
compounds. Recent studies have focused on marine organisms as a source of natural bioactive molecules having a photoprotective
role, their biosynthesis and commercial application. However, there is a need for extensive work to explore the photoprotective
role of various UV-absorbing compounds from marine habitats so that a range of biotechnological and pharmaceutical applications
can be found. 相似文献
2.
Isolating bioactive compounds from marine organisms 总被引:4,自引:0,他引:4
《Journal of Marine Biotechnology》1997,5(4):187-193
3.
Diketopiperazines (DKPs), which are cyclic dipeptides, have been detected in a variety of natural resources. Recently, the interest in these compounds increased significantly because of their remarkable bioactivity. This review deals with the chemical structures, biosynthetic pathways, and biological activities of DKPs from marine microorganisms, sponges, sea stars, tunicates (ascidians), and red algae. The literature has been covered up to December 2008, and a total 124 DKPs from 104 publications have been discussed and reviewed. Some of these compounds have been found to possess various bioactivities including cytotoxicity, and antibacterial, antifungal, antifouling, plant-growth regulatory, and other activities. 相似文献
4.
《Comparative biochemistry and physiology. B, Comparative biochemistry》1992,101(3):733-736
- 1.1. Different methods for extraction of low molecular weight compunds (lipids, terpenoids, steroids, glycosides, etc.) from Black Sea invertebrates and algae were examined.
- 2.2. The composition and quantity of the extracts were found to depend strongly on the type of the organisms and on the solvents used for extraction.
- 3.3. Thin-layer chromatography was found to be convenient for rapid identification of low molecular weight compounds in the extracts.
- 4.4. An approach has been developed which was suitable for field experimentrsand was successfully applied for the analysis of five algae and seven invertebrates from the Black Sea.
5.
Structures, taxonomic distribution and biological activities of steroid glycosides isolated from marine organisms over the last 8-10 years are reviewed. The bibliography includes 130 references. 相似文献
6.
Since early human history, plants have served as the most important source of medicinal natural products, and even in the
“synthetic age” the majority of lead compounds for pharmaceutical development remain of plant origin. In the marine realm,
algae and seagrasses were amongst the first organisms investigated by marine natural products scientists on their quest for
novel pharmaceutical compounds. Forty years after the pioneering work in the field of marine drug discovery began, the biodiversity
of marine organisms investigated as potential sources of anticancer, anti-inflammatory, and antibiotic compounds has increased
tremendously. Nonetheless, marine plants are still an important source of novel secondary metabolites with interesting biomedical
properties. The present review focuses on the antitumour properties of compounds isolated from marine algae, phytoplankton,
mangroves, seagrasses, or cordgrasses. Compounds produced by marine epi- or endophytic fungi are also discussed. 相似文献
7.
In this study, we investigate the type and quantity of selenium compounds in fish and marine organisms, using ion-pair reversed phase LC–ICP-MS, developed and applied for the analysis of Atlantic cod, Atlantic salmon, Greenland halibut, Atlantic herring, blue mussel, common crab, scallop, calanus, and Euphasia super. Of the samples examined, the lowest level of selenium was found in farmed Atlantic salmon (0.17 mg Se kg−1 dm). The total selenium extraction efficiency by phosphate buffer was 2.5 times higher in sea plankton and shellfish samples than in fish samples. Analysis of Se species in each hydrolysate obtained by proteolysis showed the presence of selenomethionine, which constituted 41.5% of the selenium compounds detected in hydrolysates of Atlantic herring and 98.4% of those in extracts of Atlantic salmon. Inorganic compounds, such as selenates and selenites, were detected mainly in sea plankton and shellfish samples (<0.13 mg Se kg−1 wm), although no correlation was found between the presence of inorganic compounds and total selenium concentration. The accuracy of the total selenium determination was validated using a certified reference material (oyster tissue (NIST 1566b)). A lyophilised powder of cod (Gadus morhua) was used to validate speciation analysis, enzymatic hydrolysis of lyophilised powder of cod recovered 54 ± 6% of total selenium, and SeMet constituted 83.5 ± 5.28% of selenium detected in hydrolysates. The chromatographic detection limits were, respectively, 0.30 ng mL−1, 0.43 ng mL−1, 0.54 ng mL−1, 0.55 ng mL−1, 0.57 ng mL−1 and 0.72 ng mL−1 for selenate, selenomethionine, selenite, Se-methyl-selenocysteine, selenocystine and selenomethionine selenoxide.The data on selenium concentrations and speciation presented here could be useful in estimating levels of selenium intake by seafood consumption. 相似文献
8.
ERBAN PROCHE 《Biological journal of the Linnean Society. Linnean Society of London》2001,74(2):197-203
Secondary marine organisms belong to groups of terrestrial ancestry which have recolonized marine habitats. Some of them are, to various degrees, still dependent on the terrestrial habitat where they originated, which imposes certain limits in the expansion of their distribution range. This makes them an ideal subject for historical reconstruction. Here I perform biogeographical analyses on the global distribution of 12 groups of land-dependent secondary marine plants and animals (mangrove trees, sea turtles, sea snakes, seabirds and seals). When all groups are taken together, species diversity shows a unique bimodal pattern for each hemisphere, with high values in cold-temperate and tropical regions, but low values in mid-latitude regions. None of the individual groups considered reaches its highest species concentration in mid-latitude regions. This is shown to be due to the existence of three different species assemblages, inhabiting the three species-rich latitudinal bands (northern cold-temperate, tropical, and southern cold-temperate), and intermixing to a limited degree in the species-poor mid-latitude bands. This is evidence that secondary marine organisms diversified independently in cold-temperate and tropical regions, and strongly suggests that colonization from terrestrial habitats took place independently in the three species-rich latitudinal bands. Different constraints in the terrestrial habitat of origin are put forward as evolutionary incentives for colonizing the sea: glaciation processes in cold regions and competition in tropical regions. 相似文献
9.
Lazcano-Pérez F Román-González SA Sánchez-Puig N Arreguin-Espinosa R 《Protein and peptide letters》2012,19(7):700-707
Marine organisms are an immense source of new biologically active compounds. These compounds are unique because the aqueous environment requires a high demand of specific and potent bioactive molecules. Diverse peptides with a wide range of biological activities have been discovered, including antimicrobial, antitumoral, and antiviral activities and toxins amongst others. These proteins have been isolated from different phyla such as Porifera, Cnidaria, Nemertina, Crustacea, Mollusca, Echinodermata and Craniata. Purification techniques used to isolate these peptides include classical chromatographic methods such as gel filtration, ionic exchange and reverse-phase HPLC. Multiple in vivo and in vitro bioassays are coupled to the purification process to search for the biological activity of interest. The growing interest to study marine natural products results from the discovery of novel pharmacological tools including potent anticancer drugs now in clinical trials. This review presents examples of interesting peptides obtained from different marine organisms that have medical relevance. It also presents some of the common methods used to isolate and characterize them. 相似文献
10.
Current strategies for bone repair have accepted limitations and the search for synthetic graft materials or for scaffolds that will support ex vivo bone tissue engineering continues. Biomimetic strategies have led to the investigation of naturally occurring porous structures as templates for bone growth. The marine environment is rich in mineralizing organisms with porous structures, some of which are currently being used as bone graft materials and others that are in early stages of development. This review describes the current evidence available for these organisms, considers the relative promise of each and suggests potential future directions. 相似文献
11.
Se-Kwon Kim Y. Dominic Ravichandran Sher Bahadar Khan Young Tae Kim 《Biotechnology and Bioprocess Engineering》2008,13(5):511-523
Cosmeceuticals, derived from the words ‘cosmetic and pharmaceutical’, have drug-like benefits and contain active ingredients
such as vitamins, phytochemicals, enzymes, antioxidants, and essential oils. Cosmeceuticals have attracted increased attention
because of their beneficial effects on human health. Bioactive substances derived from marine organisms have diverse functional
roles as a secondary metabolite and these properties can be applied to the developments of novel pharmaceuticals and cosmeceuticals.
Recently, extensive studies have been conducted on the general aspects of the chemical structures, physical and biochemical
properties, and biotechnological applications of bioactive substances derived from marine organisms. In this review, we have
discussed recent progresses in the biotechnological applications of bioactive substances from marine organisms as cosmeceuticals. 相似文献
12.
Lakshmi V Goel AK Srivastava MN Kulshreshtha DK Raghubir R 《Indian journal of experimental biology》2006,44(2):137-141
Alcoholic extracts of 48 identified species of marine flora were screened for a wide range of biological activities. Of these, 3 extracts showed diuretic activity while 2 extracts showed hypotensive effect. 相似文献
13.
Lakshmi V Goel AK Srivastava MN Raghubir R 《Indian journal of experimental biology》2006,44(9):754-756
Methanolic and chloroform-methanol extracts of 25 identified species of marine fauna have been screened for a wide range of biological activities. Of these, 2 extracts exhibited diuretic activity, while antibacterial, antiviral, oxytocic and spasmolytic activities, were observed in 1 extract each. 相似文献
14.
D S Bhakuni B N Dhawan H S Garg A K Goel B N Mehrotra R C Srimal M N Srivastava 《Indian journal of experimental biology》1992,30(6):512-517
Alcoholic extracts of 50 botanically identified species of marine flora have been screened for a wide range of biological activities. Of these, 2 extracts exhibited anti-amoebic and antiviral activity each, 3 of them had anti-implantation activity; 9 had hypoglycaemic activity while hypotensive activity was associated with 11 extracts; 14 extracts were found to be diuretic and 1 of them had anti-inflammatory activity. Further, 10 of these extracts exhibited 2 types of activities while a combination of 3 and 4 types of activities was observed in one extract each. Follow-up studies have been carried out in some plants with confirmed activity. The active principles and results of these studies are reported. 相似文献
15.
Beverly K. Pierson Diane Valdez Mark Larsen Elizabeth Morgan E. Erin Mack 《Photosynthesis research》1994,41(1):35-52
We report the presence of a diverse number ofChloroflexus-like organisms in intertidal marine and submerged hypersaline microbial mats using light, infrared fluorescence, and electron microscopy. The intertidal organisms appear morphologically very similar to thermophilicC. aurantiacus while the 2 hypersaline strains are larger and have a more complex ultrastructure composed of chlorosome-bearing internal membranes that appear to arise as invaginations of the cell membrane. By comparing spectroradiometry of microbial mat layers with microscopic observations, we have confirmed that theChloroflexus-like organisms are major constituents of the hypersaline microbial mat communities. In situ studies on mat layers dominated byChloroflexus-like organisms showed that sulfide-dependent photoautotrophic activity sustained by near infrared radiation prevailed. Autoradiographic analyses revealed that autotrophy was sustained in the filaments by 750 nm radiation. Three morphologically distinct strains are now maintained in mixed culture. One of these appears to be growing photoautotrophically. 相似文献
16.
Rama Rao Malla Batoul Farran Ganji Purnachandra Nagaraju 《World journal of biological chemistry》2021,12(2):15-37
The pathology and physiology of breast cancer(BC),including metastasis,and drug resistance,is driven by multiple signaling pathways in the tumor microenvironment(TME),which hamper antitumor immunity.Recently,long non-coding RNAs have been reported to mediate pathophysiological developments such as metastasis as well as immune suppression within the TME.Given the complex biology of BC,novel personalized therapeutic strategies that address its diverse pathophysiologies are needed to improve clinical outcomes.In this review,we describe the advances in the biology of breast neoplasia,including cellular and molecular biology,heterogeneity,and TME.We review the role of novel molecules such as long non-coding RNAs in the pathophysiology of BC.Finally,we provide an up-to-date overview of anticancer compounds extracted from marine microorganisms,crustaceans,and fishes and their synergistic effects in combination with other anticancer drugs.Marine compounds are a new discipline of research in BC and offer a wide range of anti-cancer effects that could be harnessed to target the various pathways involved in BC development,thus assisting current therapeutic regimens. 相似文献
17.
Phytochemistry Reviews - Marine fungi with complex genetic backgrounds and large metagenomes are a main source of marine natural products in the past 20 years. This review highlights the... 相似文献
18.
Bioactive compounds from marine actinomycetes 总被引:1,自引:0,他引:1
Actinomycetes are one of the most efficient groups of secondary metabolite producers and are very important from an industrial
point of view. Among its various genera, Streptomyces, Saccharopolyspora, Amycolatopsis, Micromonospora and Actinoplanes are the major producers of commercially important biomolecules. Several species have been isolated and screened from the
soil in the past decades. Consequently the chance of isolating a novel actinomycete strain from a terrestrial habitat, which
would produce new biologically active metabolites, has reduced. The most relevant reason for discovering novel secondary metabolites
is to circumvent the problem of resistant pathogens, which are no longer susceptible to the currently used drugs. Existence
of actinomycetes has been reported in the hitherto untapped marine ecosystem. Marine actinomycetes are efficient producers
of new secondary metabolites that show a range of biological activities including antibacterial, antifungal, anticancer, insecticidal
and enzyme inhibition. Bioactive compounds from marine actinomycetes possess distinct chemical structures that may form the
basis for synthesis of new drugs that could be used to combat resistant pathogens. 相似文献
19.
W. A. Maher 《Biological trace element research》1984,6(2):159-164
A review of the nature and accumulation of arsenic in marine organisms is presented. A study of the literature has revealed a lack of information about the mechanisms of uptake, molecular transformations, and biochemical associations of arsenic within organisms, and it remains unclear whether a few forms of arsenic are ubiquitous. The arsenic forms present in marine sediments and their role in the biogeochemical cycling of arsenic are also largely unknown. 相似文献
20.
V. V. Sova M. S. Pesentseva A. M. Zakharenko S. N. Kovalchuk T. N. Zvyagintseva 《Biochemistry. Biokhimii?a》2013,78(7):746-759
This review discusses the catalytic properties, activity regulation, structure, and functions of O-glycoside hydrolases from marine organisms exemplified by endo-1→3-β-D-glucanases of marine invertebrates. 相似文献