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Summary Zymosan given to rats, normal or splenectomized, stimulates the RES of the liver. Under this stimulation, the endothelial cells of the sinusoids change into Kupffer cells. The endothelial cells become hypertrophic and multiply; they acquire progressively the properties of phagocytosis and of digestion shown by the Kupffer cells. Hence both types of cells — the endothelial and the Kupffer cells — belong to the same cellular lineage. Their various aspects result from different functional states.The hyperplasia of the liver RES has no repercussion on the fine structure of the hepatic cells.
Résumé L'administration de Zymosan à des rats, splénectomisés ou non, provoque une stimulation du SRE du foie. Sous l'effet de cette stimulation, les cellules endothéliales des sinusoïdes se transforment en cellules de Kupffer. Les cellules endothéliales s'hypertrophient et se multiplient; progressivement, elles acquiérent les propriétés de phagocytose et de digestion des cellules de Kupffer. Les deux types de cellules — endothéliales et cellules de Kupffer — appartiennent donc bien à la même lignée cellulaire. Leurs divers aspects correspondent à des états fonctionnels différents.L'hyperplasie du SRE du foie n'a pas de répercussion sur l'ultrastructure des hépatocytes.


Mit Unterstützung durch den Schweizerischen Nationalfond für die Förderung der Wissenschaftlichen Forschung.

Stipendiat der Organisation Mondiale de la Santé.Übersetzung von Frau Antje Forssmann, technische Mitarbeit von Max Baumann, Michel Bernard und Charles Moreillon.  相似文献   

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Summary The close relationship between phages T 1 and D 20 was confirmed by genetical crosses. D 20 could be shown to differ from T 1 by at least two genes, both affecting the host range of the phage. The geneDs will render a phage capable of multiplying on the original host of D 20, SF;Ha will enable the phage to lyse B/1. D 20 may thus be formulated as T 1HaDs. Both genes could be localized within the T 1 linkage map, in the vicinity of the geneHr, which is known to control the host range specifity against B/1. The results of genetical, adsorption, and serological studies can be interpreted by the assumption that each gene controls the synthesis of a specific protein, responsible for the adsorption behaviour of the particular phage. A phage will adsorb to SF according to itsDs genotype, to B or its phage resistant mutants according to itsHa genotype. These proteins do not, however, exert their functions independently. Therates of adsorption and neutralization are influenced by the presence or absence of proteins not required for the particular reaction under investigation.

Mit 4 Textabbildungen  相似文献   

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Ohne Zusammenfassung2. Mitteilung der Untersuchungen über biologisch wirksame Strahlungen vonRomeis, Wimmer undWüst.  相似文献   

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Ibex and chamois of the Alps – genetic variability and biochemical differentiation between species Genetic variability of 46 specimens of ibex (Capra ibex ibexL.) from Graubünden/Switzerland was investigated by means of horizontal starch gel electrophoresis. Twenty four isoenzyme systems were examined in kidney and liver tissues. From 38 loci scored 5.3 % were polymorphic (PGM-2, ADA-1) and average heterozygosity was 0.0235. The comparatively low proportion of polymorphic loci can be interpreted as the result of a bottleneck in alpine ibex during the last centuries. Based on a ¯-value of 0,2746 a time of divergence between ibex and chamois of about 1370000 years was calculated.  相似文献   

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Ohne Zusammenfassung  相似文献   

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Ohne ZusammenfassungVgl. diese Zeitschrift Bd. 25, 124.  相似文献   

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Ohne ZusammenfassungVgl. diese Zeitschrift,24, 470 (1935).  相似文献   

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