共查询到20条相似文献,搜索用时 343 毫秒
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Izumi M Yokoi M Nishikawa NS Miyazawa H Sugino A Yamagishi M Yamaguchi M Matsukage A Yatagai F Hanaoka F 《Biochimica et biophysica acta》2000,1492(2-3):341-352
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P F Lambert M J Ludford-Menting N J Deacon I Kola R R Doherty 《Molecular biology of the cell》1997,8(2):313-323
The gene encoding NFKB1 is autoregulated, responding to NF-kappa B/Rel activation through NF-kappa B binding sites in its promoter, which also contains putative sites for Ets proteins. One of the Ets sites, which we refer to as EBS4, is located next to an NF-kappa B/Rel binding site, kB3, which is absolutely required for activity of the promoter in Jurkat T cells in response to activation by phorbol 12-myristate 13-acetate (PMA), PMA/ionomycin, or the Tax protein from human T cell leukemia virus type I. We show that EBS4 is, required for the full response of the nfkb1 promoter to PMA or PMA/ionomycin in Jurkat cells. EBS4 is bound by Ets-1, Elf-1, and other species. Overexpression of Ets-1 augments the response to PMA/ionomycin and this is reduced by mutation of EBS4. Elf-1 has less effect in conjunction with PMA/ionomycin, but by itself activates the promoter 12-fold. This activation is only partly affected by mutation of EBS4, and a mutant promoter that binds Ets-1, but not Elf-1, at the EBS4 site responds to PMA/ionomycin as efficiently as the wild-type. Ets proteins may be responsible for fine-tuning the activity of the nfkb1 gene in a cell-type-specific manner. 相似文献
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Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3. 总被引:5,自引:0,他引:5
Mingfeng Liu Julian L Leibowitz David A Clark Michael Mendicino Qin Ning Jin Wen Ding Cheryl D'Abreo Laisum Fung Philip A Marsden Gary A Levy 《European journal of biochemistry》2003,270(10):2274-2286
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J W Innis D J Moore S F Kash V Ramamurthy M Sawadogo R E Kellems 《The Journal of biological chemistry》1991,266(32):21765-21772
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Wenfang Liu Geping Wang Alexander G Yakovlev 《The Journal of biological chemistry》2002,277(10):8273-8278