共查询到20条相似文献,搜索用时 15 毫秒
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Genesio M Karere Jeremy P Glenn John L VandeBerg Laura A Cox 《Journal of biomedical science》2010,17(1):54
Background
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however, no baboon miRNAs have been identified. Evidence indicates that the baboon and human genomes are highly conserved; based on this conservation, we hypothesized that comparative genomic methods could be used to identify baboon miRNAs. 相似文献2.
Weiwu Jin Jason R Grant Paul Stothard Stephen S Moore Le Luo Guan 《BMC molecular biology》2009,10(1):90
Background
MicroRNAs (miRNAs) are a family of ~22 nucleotide small RNA molecules which regulate gene expression by fully or partially binding to their complementary sequences in mRNAs or promoters. A large number of miRNAs and their expression patterns have been reported in human, mouse and rat. However, miRNAs and their expression patterns in live stock species such as beef cattle are not well studied. 相似文献3.
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Edyta Koscianska Vesselin Baev Konstantinia Skreka Katerina Oikonomaki Ventsislav Rusinov Martin Tabler Kriton Kalantidis 《BMC molecular biology》2007,8(1):79
Background
MicroRNAs (miRNAs) are one of the most abundant groups of regulatory genes in multicellular organisms, playing important roles in many fundamental cellular processes. More than four hundred miRNAs have been identified in humans and the deregulation of miRNA expression has been also shown in many cancers. Despite the postulated involvement of miRNAs in tumourigenesis, there are only a few examples where an oncogene or a tumour suppressor has been identified as a miRNA target. 相似文献7.
Erika Varkonyi-Gasic Nick Gould Manoharie Sandanayaka Paul Sutherland Robin M MacDiarmid 《BMC plant biology》2010,10(1):159
Background
Plant microRNAs (miRNAs) are a class of small, non-coding RNAs that play an important role in development and environmental responses. Hundreds of plant miRNAs have been identified to date, mainly from the model species for which there are available genome sequences. The current challenge is to characterise miRNAs from plant species with agricultural and horticultural importance, to aid our understanding of important regulatory mechanisms in crop species and enable improvement of crops and rootstocks. 相似文献8.
Geng Tian XuYang Yin Hong Luo XiaoHong Xu Lars Bolund XiuQing Zhang 《BMC biotechnology》2010,10(1):64
Background
MicroRNAs(miRNAs) are 18-25 nt small RNAs playing critical roles in many biological processes. The majority of known miRNAs were discovered by conventional cloning and a Sanger sequencing approach. The next-generation sequencing (NGS) technologies enable in-depth characterization of the global repertoire of miRNAs, and different protocols for miRNA library construction have been developed. However, the possible bias between the relative expression levels and sequences introduced by different protocols of library preparation have rarely been explored. 相似文献9.
Stephen F Madden Susan B Carpenter Ian B Jeffery Harry Björkbacka Katherine A Fitzgerald Luke A O'Neill Desmond G Higgins 《BMC bioinformatics》2010,11(1):257
Background
MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to the messenger RNA (mRNA) of protein coding genes. They control gene expression by either inhibiting translation or inducing mRNA degradation. A number of computational techniques have been developed to identify the targets of miRNAs. In this study we used predicted miRNA-gene interactions to analyse mRNA gene expression microarray data to predict miRNAs associated with particular diseases or conditions. 相似文献10.
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Alberto Biscontin Silvia Casara Stefano Cagnin Lucia Tombolan Angelo Rosolen Gerolamo Lanfranchi Cristiano De Pittà 《BMC molecular biology》2010,11(1):44
Background
microRNAs (miRNAs) are small single-stranded non-coding RNAs that act as crucial regulators of gene expression. Different methods have been developed for miRNA expression profiling in order to better understand gene regulation in normal and pathological conditions. miRNAs expression values obtained from large scale methodologies such as microarrays still need a validation step with alternative technologies. 相似文献14.
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Mingming Xin Yu Wang Yingyin Yao Chaojie Xie Huiru Peng Zhongfu Ni Qixin Sun 《BMC plant biology》2010,10(1):123
Background
MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs that regulate gene expression by guiding target mRNA cleavage or translational inhibition. MiRNAs can have large-scale regulatory effects on development and stress response in plants. 相似文献17.
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Weaver DB Anzola JM Evans JD Reid JG Reese JT Childs KL Zdobnov EM Samanta MP Miller J Elsik CG 《Genome biology》2007,8(6):R97
Background
Non-coding microRNAs (miRNAs) are key regulators of gene expression in eukaryotes. Insect miRNAs help regulate the levels of proteins involved with development, metabolism, and other life history traits. The recently sequenced honey bee genome provides an opportunity to detect novel miRNAs in both this species and others, and to begin to infer the roles of miRNAs in honey bee development. 相似文献19.
Koichi Murata Hiroyuki Yoshitomi Shimei Tanida Masahiro Ishikawa Kohei Nishitani Hiromu Ito Takashi Nakamura 《Arthritis research & therapy》2010,12(3):R86
Introduction
MicroRNAs (miRNAs), endogenous small noncoding RNAs regulating the activities of target mRNAs and cellular processes, are present in human plasma in a stable form. In this study, we investigated whether miRNAs are also stably present in synovial fluids and whether plasma and synovial fluid miRNAs could be biomarkers of rheumatoid arthritis (RA) and osteoarthritis (OA). 相似文献20.
Jinghuan Li Paul Smyth Richard Flavin Susanne Cahill Karen Denning Sinead Aherne Simone M Guenther John J O'Leary Orla Sheils 《BMC biotechnology》2007,7(1):36