All natural

Natural products research focuses on the chemical properties, biosynthesis and biological functions of secondary metabolites. As our scientific understanding of all things 'natural' is rapidly expanding, we should also make time to communicate the subtleties of chemical distinctions to the public.     

All systems go

Reductionism has served cell biologists well in the past decades, but systems biologists are now promising to broaden the picture. The challenge will be to provide not just the lists and quantitation but real mechanistic insights.     

Warts and All

A closer examination of the ways archaeological knowledge is spoken about and represented locally provides significant insights into social divisions and power struggles within Peru. In an account of the ambivalent relations between archaeologists and local experts in the prehispanic past, this article considers how the authority that enables the construction and maintenance of sociopolitical models (such as the ‘nation’) is itself constructed, not just from above, but also at the local level. The relationship between power and authority grants legitimacy to historical discourses justifying sociopolitical inequality and reinforces the centralized power structure of the Peruvian state. The article discusses the implications of these local perceptions for archaeology, both as a discipline practiced within the local setting, and as a category through which the Peruvian government expresses tropes of a unified modern identity.     

All together now

Maintenance of genomic stability during eukaryotic cell division relies on the Spindle Assembly Checkpoint (SAC), which has evolved as a surveillance mechanism that monitors kinetochore-microtubule attachment and prevents APC/C-mediated mitotic exit until all chromosomes are properly attached to the mitotic spindle. Reversible protein phosphorylation has long been accredited as a regulatory mechanism of the SAC. Nevertheless, knowledge of how several mitotic kinases act in concert within the signaling pathway to orchestrate SAC function is still emerging. In a recent study, we undertook a comprehensive dissection of the hierarchical framework controlling SAC function in Drosophila cells. We found that Polo lies at the top of the SAC pathway promoting the efficient recruitment of Mps1 to unattached kinetochores. This renders Mps1 fully active to control BubR1 phosphorylation that generates the 3F3/2 phosphoepitope at tensionless kinetochores. We have proposed that Polo is required for SAC function and that the molecular outcome of Mps1-dependent 3F3/2 formation is to promote the association of Cdc20 with BubR1 allowing proper kinetochore recruitment of Cdc20 and efficient assembly of the Mitotic Checkpoint Complex (MCC) required for a sustained SAC response.