共查询到20条相似文献,搜索用时 46 毫秒
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Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer. 总被引:32,自引:4,他引:28
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![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
J Hiscott D Alper L Cohen J F Leblanc L Sportza A Wong S Xanthoudakis 《Journal of virology》1989,63(6):2557-2566
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The v-rel oncogene encodes a kappa B enhancer binding protein that inhibits NF-kappa B function 总被引:103,自引:0,他引:103
D W Ballard W H Walker S Doerre P Sista J A Molitor E P Dixon N J Peffer M Hannink W C Greene 《Cell》1990,63(4):803-814
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Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. 总被引:15,自引:1,他引:14
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![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
J Hiscott J Marois J Garoufalis M D'Addario A Roulston I Kwan N Pepin J Lacoste H Nguyen G Bensi et al. 《Molecular and cellular biology》1993,13(10):6231-6240
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Two distinct NF-kappa B complexes differing in their larger subunit bind the E-selectin promoter kappa B element. 总被引:2,自引:1,他引:1
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![点击此处可从《Nucleic acids research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
We have investigated the proteins binding the E-selectin promoter NF-kappa B element in its natural DNA context, using probes extending beyond the NF-kappa B recognition decamer. In band shift assays, we detected two distinct NF-kappa B complexes using nuclear extracts from several cytokine-induced cells. Subunit-specific antisera as blockers of complex formation plus DNA-protein cross-linking experiments revealed the faster migrating form to contain the NF-kappa B p50 plus p65 subunits. In contrast, the slower migrating form is composed of p50 plus the p65-related p75 protein. We show as the crucial determinant in generation of the larger complex the presence of more than five basepairs extra DNA sequence downstream of the NF-kappa B-site. Although no specific sequence is required in this 3' extended DNA to bind the larger complex, an intact kappa B binding site is. This may be explained by a requirement for activated p50 as part of this complex. The potential for a regulatory role for the p75 containing complex on the E-selectin promoter is discussed. 相似文献
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A striking similarity in the organization of the E-selectin and beta interferon gene promoters. 总被引:17,自引:6,他引:11
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M Z Whitley D Thanos M A Read T Maniatis T Collins 《Molecular and cellular biology》1994,14(10):6464-6475
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