How not to get cross(ed)

Comment on: Lorenz A, et al. Science 2012; 336:1585-8.     

How (not) to model autonomous behaviour

Autonomous systems are the result of self-sustaining processes of constitution of an identity under precarious circumstances. They may transit through different modes of dynamical engagement with their environment, from committed ongoing coping to open susceptibility to external demands. This paper discusses these two statements and presents examples of models of autonomous behaviour using methods in evolutionary robotics. A model of an agent capable of issuing self-instructions demonstrates the fragility of modelling autonomy as a function rather than as a property of a system's organization. An alternative model of behavioural preference based on homeostatic adaptation avoids this problem by establishing a mutual constraining between lower-level processes (neural dynamics and sensorimotor interaction) and higher-level metadynamics (experience-dependent, homeostatic triggering of local plasticity and re-organization). The results of these models are lessons about how strong autonomy should be approached: neither as a function, nor as a matter of external vs. internal determination.     

How to succeed in science

Adherence to these principles will not guarantee success, but the testimony of many famous scientists supports the hypothesis that these guidelines can significantly (p less than .05, Wilcoxon unpaired X-test run at pH 5.6) increase your chances of achieving recognition, acquiring wealth, and ultimately being known as a successful scientist. At the very least, they should prevent you from falling too far outside the boundaries of "normal" science where you could easily be branded for life as a troublemaker or heretic.     

How plants communicate using the underground information superhighway

The rhizosphere is a densely populated area in which plant roots must compete with invading root systems of neighboring plants for space, water, and mineral nutrients, and with other soil-borne organisms, including bacteria and fungi. Root-root and root-microbe communications are continuous occurrences in this biologically active soil zone. How do roots manage to simultaneously communicate with neighboring plants, and with symbiotic and pathogenic organisms within this crowded rhizosphere? Increasing evidence suggests that root exudates might initiate and manipulate biological and physical interactions between roots and soil organisms, and thus play an active role in root-root and root-microbe communication.     

Building for an exit (or not)

A young biotech firm can grow in several ways. The key to success is preparing for them all.     

The success (or not) of HUGO nomenclature

Current usage of gene nomenclature is ambiguous and impairs the efficient handling of scientific information. Therefore it is important to propose guidelines to deal with this problem. This study attempts to evaluate the success of HUGO nomenclature for human genes. The results indicate that HUGO guidelines are not supported by the scientific community.     

To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications

Smad proteins are key signal transducers for the TGF-beta superfamily and are frequently inactivated in human cancers, yet the molecular basis of how their levels and activities are regulated remains unclear. Recent progress, discussed herein, illustrates the critical roles of Smad post-translational modifications in the cellular outcome to TGF-beta signaling.