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vrille,Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock 总被引:9,自引:0,他引:9
Cyran SA Buchsbaum AM Reddy KL Lin MC Glossop NR Hardin PE Young MW Storti RV Blau J 《Cell》2003,112(3):329-341
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Hardin PE 《Journal of biological rhythms》2004,19(5):348-360
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Interactions between plant circadian clocks and solute transport 总被引:1,自引:0,他引:1
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A mechanism for generating circadian rhythms has been of major interest in recent years. After the discovery of per and tim, a model with a simple feedback loop involving per and tim has been proposed. However, it is recognized that the simple feedback model cannot account for phenotypes generated by various mutants. A recent report by Glossop, Lyons & Hardin [Science286, 766 (1999)] on Drosophila suggests involvement of another feedback loop by dClk that is interlocked with per-tim feedback loop. In order to examine whether interlocked feedback loops can be a basic mechanism for circadian rhythms, a mathematical model was created and examined. Through extensive simulation and mathematical analysis, it was revealed that the interlocked feedback model accounts for the observations that are not explained by the simple feedback model. Moreover, the interlocked feedback model has robust properties in oscillations. 相似文献
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