共查询到20条相似文献,搜索用时 15 毫秒
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Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS 总被引:2,自引:0,他引:2
Yamashita T Ohneda O Nagano M Iemitsu M Makino Y Tanaka H Miyauchi T Goto K Ohneda K Fujii-Kuriyama Y Poellinger L Yamamoto M 《Molecular and cellular biology》2008,28(4):1285-1297
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Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha 总被引:12,自引:0,他引:12
Gothié E Richard DE Berra E Pagès G Pouysségur J 《The Journal of biological chemistry》2000,275(10):6922-6927
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Hypoxia-inducible factor 1 transactivates the human leptin gene promoter 总被引:15,自引:0,他引:15
Grosfeld A Andre J Hauguel-De Mouzon S Berra E Pouyssegur J Guerre-Millo M 《The Journal of biological chemistry》2002,277(45):42953-42957
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During early pregnancy, an environment of relative low oxygen tension is essential for normal embryonic and placental vasculature. In low-oxygen conditions, the hypoxic-inducible factor-1 (HIF-1), composed of alpha and beta subunits, controls the expression of a number of genes such as vascular endothelial growth factor (VEGF), a key angiogenic factor. The recent studies in some tumor cells have found that the labile component, HIF-1 alpha, is not only activated by hypoxia but also by peptides such as interleukin-1 (IL-1) in normoxia. In this article, we demonstrated that exposure of normal human cytotrophoblast cells to IL-1 beta stimulated the expression of HIF-1 alpha protein. Meanwhile, IL-1 beta also induced the secretion of VEGF in normal human cytotrophoblast cells. Our data indicated that IL-1 beta induced extracellular signal-regulated kinase (ERK) 1/2 phosphorylation. Moreover, treatment of cells with PD98059, an inhibitor of ERK1/2 signaling, inhibited the stimulation of HIF-1 alpha protein expression and VEGF secretion by IL-1 beta. These data indicate that, in normal human cytotrophoblast cells, IL-1 beta induces HIF- 1 alpha-mediated VEGF secretion and that IL-1 beta-stimulated ERK1/2 activation may be involved in this process. 相似文献
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Mammalian gene expression in hypoxic conditions 总被引:1,自引:0,他引:1
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