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A. Besson C. Baillet C. Herbaux C. Foucher A. Lambilliotte F. Morschhauser D. Huglo 《Médecine Nucléaire》2018,42(2):114-124
Purpose
The aim of our study was to assess the variability of 18-FDG uptake in the liver and the relationship between hepatic SUVs and SULs and several clinical and technical factors among patients with 18-FDG avid lymphoma.Methods
Two hundred and thirty eight patients who underwent 18-FDG PET/CT for a Hodgkin lymphoma (HL), Diffuse Large B Cell Lymphoma (DLBCL) or mantle Cell Lymphoma (MCL) at baseline (PET1), interim (PET2), and end-of-treatment (PET3) were retrospectively included. Linear regression models were used to assess the variability of hepatic SUVmax, SUVmean, SULmax and SULmean. Correlation between SUVs and SULs and several factors including Body Mass Index (BMI), age, histological type, Ann Arbor classification, LDH levels, AST and ALT levels, chemotherapy, corticosteroid therapy, fasting blood glucose, uptake time, and injected activity. Univariate and multivariate regression models were established. Finally, we compared residual lymphoma and hepatic SUVs at PET2 and PET3 for the patients categorized Deauville 3 and 4.Results
Liver SUVs were all significantly increased at PET2 and PET3 in comparison with PET1. SULmean was the less variable index. BMI, age, histological type and injected dose were significantly associated with SUVs. In multivariate analysis, only BMI and injected dose remained significantly associated with hepatic SUVs. Residual tumoral uptake at PET2 were lower than hepatic SUVmax in 32/47 patients classified Deauville 3 and higher than hepatic SUVmean and SULmax in almost all Deauville 3 patients.Conclusion
While the hepatic SUVmax was the most prone to variability, especially sensitive to BMI, it appears to be more appropriate than SUVmean or SULmax in assessing tumor response to treatment. Factors affecting SUVs must be considered in the evaluation of therapeutic response in lymphoma. 相似文献10.
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