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1.
This prospective study was designed to compare the hair levels of 36 elements in 52 patients with stage III breast cancer to those of an equal number of healthy individuals. Principal component and cluster analysis were used for source of identification and apportionment of heavy metals and trace elements in these two groups. A higher average level of iron was found in samples from patients while controls had higher levels of calcium. Both patients and controls had elevated levels of tin, magnesium, zinc, and sodium. Almost all element values in cancer patients showed higher dispersion and asymmetry than in healthy controls. Between the two groups, there were statistically significant differences in the concentrations of silver, arsenic, gold, boron, barium, beryllium, calcium, cadmium, cerium, cobalt, cesium, gadolinium, manganese, nickel, lead, antimony, scandium, selenium, and zinc (p?0.05). Strong positive correlations were found between lead and gold (r?=?0.785) in the cancer group and between palladium and cobalt (r?=?0.945) in the healthy individuals. Our results show that there are distinct patterns of heavy metals and trace elements in the hair of breast cancer patients in comparison to healthy controls. These results could be of significance in the diagnosis of breast cancer. 相似文献
2.
Lin Kuangfei Xiang Yaling Liu Xuefeng Wu Zuoli Sandra G. F. Bukkens Mila Tommaseo 《植物科学评论》1999,18(3):417-428
Metallic elements in hair were assessed in human subjects randomly sampled from six villages in Hubei province, PR China, known to differ in industrial pollution. Metallic elements assessed included copper, zinc, lead, and cadmium. Subjects sampled included adults and children of both sexes. Soil and rice samples from the villages were also examined for contents of metallic elements. Soil and rice contents of copper, lead, and cadmium were higher in the villages closer to the pollution source (copper smeltery). Hair contents of copper, lead, and cadmium were higher in subjects from the polluted villages compared with subjects from the nonpolluted areas. No differences were found in hair zinc content among the villagers. Cadmium contents in rice and human hair were linearly correlated. For lead and copper a logarithmic relation was found. No difference was found between the two genders with respect to hair metallic contents. With regard to age, hair cadmium content was highest in the older age groups in the polluted villages and may reflect chronic exposure. No other systematic age effects were observed. It was concluded that contents of cadmium, lead, and copper in human hair do reflect the degree of environmental pollution. 相似文献
3.
Joanna Suliburska Paweł Bogdański Danuta Pupek-Musialik Zbigniew Krejpcio 《Biological trace element research》2011,139(2):137-150
Inadequate minerals intake, as well as disruption of some metabolic processes in which microelements are cofactors, are suggested
to lead to the development of hypertension. The role of minerals in the pathogenesis of hypertension still remains to be explained.
In the present study, we sought to determine associations between serum and hair mineral concentrations and serum lipids and
glucose levels. Forty obese hypertensive subjects with insulin resistance and 40 healthy volunteers were recruited in the
study. Blood pressure, BMI, and insulin resistance were recorded in all subjects. Levels of lipids, glucose, sodium and potassium,
iron, copper, zinc, magnesium, and calcium were assessed in serum. Iron, copper, zinc, magnesium, and calcium were assessed
in hair. Dietary intake of the analyzed minerals was estimated. We found distinctly higher concentrations of serum iron and
serum and hair calcium as well as markedly lower levels of hair zinc in the hypertensive subjects. The study group manifested
also significantly lower daily intake of calcium, magnesium, and iron. We observed a relationship between the concentrations
of iron, zinc, and copper in serum and hair and high and low range of cholesterol, triglycerides, and glucose serum levels
in the studied patients. Moreover, this study demonstrated significant correlation between serum and hair concentrations of
selected minerals and their dietary intake and levels of serum lipids and glucose and blood pressure in the study and the
control groups. The obtained results seem to indicate the association between lipid and glucose metabolism and iron, copper,
zinc, and calcium concentrations in blood and hair of hypertensive and obese patients with insulin resistance. 相似文献
4.
Bicer M Akil M Sivrikaya A Kara E Baltaci AK Mogulkoc R 《Journal of physiology and biochemistry》2011,67(4):511-517
The present study aims to examine the effect of supplementation of zinc on the distribution of various elements in the sera
of diabetic rats subjected to an acute swimming exercise. A total of 80 Sprague–Dawley-type adult male rats were equally allocated
to one of eight groups: Group 1, general; Group 2, zinc-supplemented; Group 3, zinc-supplemented diabetic; Group 4, swimming
control; Group 5, zinc-supplemented swimming; Group 6, zinc-supplemented diabetic swimming; Group 7, diabetic swimming; and
Group 8, diabetes. The rats were injected with 40 mg/kg/day subcutaneous streptozotocin (STZ) twice, with a 24-h interval
between two injections. Zinc was supplemented at a dose of 6 mg/kg/day (ip) for 4 weeks. Blood samples were collected at the
end of the 4-week study, and serum levels of lead, cobalt, molybdenum, chrome, sulfur, magnesium, manganese, sodium, potassium,
phosphorus, copper, iron, calcium, zinc, and selenium (mg/L) were determined with atomic emission. The lowest molybdenum,
chrome, copper, iron, potassium, magnesium, sodium, phosphorus, lead, selenium, and zinc values were obtained in Group 7 and
8. These same parameters were higher in the swimming exercise group (Group 4), relative to all other groups. The values in
zinc-supplemented groups were found lower than the values in Group 4, but higher than those in Group 6 and 7. The results
obtained from the study demonstrate that acute swimming exercise and diabetes affect the distribution of various elements
in the serum, while zinc supplementation can prevent the negative conditions associated with both exercise and diabetes. 相似文献
5.
N. Gholizadeh Z. Kabiri O. Kakuee M. Saleh-kotahi V. Changizi V. Fathollahi P. Oliaiy R. Omranipour 《Biological trace element research》2013,153(1-3):105-110
To reveal the role of key elements present in the hair of breast cancer patients on cancer development, the levels of a number of elements in scalp hair samples of 82 people including healthy individuals, people suffering from benign breast disease, and breast cancer patients were measured by PIXE analysis. Pellets of hair samples were prepared and bombarded by 2.2 MeV proton beam of a 3-MV Van de Graaff accelerator. The number of incident ions hitting the sample was indirectly measured using the RBS spectrum of a thin Ag film placed in the beam path. The concentrations of S, Cl, K, Ca, Fe, and Cu in the hair of healthy individuals were in agreement with those observed in the hair of hyperplasia and cancer patients within standard deviations. However, a lower average level of zinc was found in samples from hyperplasia and breast cancer patients. Strong positive correlations were found between iron and potassium as well as between calcium and potassium in the cancer patients. These results could be of significance in the screening for breast cancer. 相似文献
6.
Marcin Słojewski Bogusław Czerny Krzysztof Safranow Katarzyna Jakubowska Maria Olszewska Andrzej Pawlik Adam Gołąb Marek Droździk Dariusz Chlubek Andrzej Sikorski 《Biological trace element research》2010,137(3):301-316
The role of trace elements in lithogenesis is still unclear. The aim of this study was to evaluate the levels of elements
in urinary stones and in the urine and hair of stone formers to identify these elements that have synergic correlations in
studied materials and may contribute to lithogenesis. A total of 219 consecutive patients with idiopathic upper urinary tract
stones were prospectively enrolled in the study. Urine and hair samples were collected from all patients. The content of the
stone was evaluated using atomic absorption spectrometry, spectrophotometry, and colorimetric methods. The analysis of 29
elements in stones and hair and 21 elements in urine was performed using inductively coupled plasma-atomic emission spectrometry.
The strength of correlation was described with the value of Spearman’s rank correlation coefficient. The positive correlation
between concentration of sodium, potassium, magnesium, barium, vanadium, zinc, silicon, phosphorus, and iodine in phosphate
stones was observed. Only a few incidental correlations between the composition of stones and the distribution of elements
in urine and in hair were found. There were 109 positive two-element correlations between two materials. The most common were
observed for vanadium, aluminum, lead, cobalt, and molybdenum. Two-element positive correlations for all samples were established
only for three elements: vanadium, lead, and aluminum. Results indicate that analysis of particular elements in hair and urine
cannot predict the composition of urinary stones. This study showed, for the first time, correlations between the levels of
vanadium, lead, and aluminum in the stones, urine, and hair of stone formers. 相似文献
7.
The camel is known to be a seasonal breeder and, in the male camel, the breeding activity maximizes during the rutting period (winter and spring seasons). During the non-rutting period (summer and autumn), however, the breeding activity almost ceases completely. Serum steroid hormonal, electrolytes and trace element profiles were studied in 16 adult male camels aged 5-9 years, slaughtered during the rutting (n=8) and non-rutting periods (n=8). Moreover, testicular and epididymal tissue contents of electrolytes and trace elements were also studied during these two periods. Serum levels of testosterone, progesterone and T(4):T(3) ratio were higher in the rutting animals when compared to the non-rutting ones, while the reverse was true for serum T(3), T(4) and corticosterone levels (p<0.01). Among minerals, serum levels of sodium, calcium, copper and zinc were higher, while those of potassium were lower, in the rutting than non-rutting camels. In the testicular tissue, the levels of sodium, calcium, copper and iron were higher in the rutting group, while magnesium was higher in non-rutting one. In the epididymis, the tissue levels of chloride, iron and zinc were higher in the rutting than non-rutting period. These results demonstrate a clear evidence of the distribution of steroid hormones, electrolytes and trace elements forming and maintaining a certain level at two different physiological states in camels. 相似文献
8.
Ochi A Ishimura E Tsujimoto Y Kakiya R Tabata T Mori K Shoji T Yasuda H Nishizawa Y Inaba M 《Biological trace element research》2011,143(2):825-834
Trace element disturbance is often observed in hemodialysis patients. While trace element concentrations have been reported
in blood samples from hemodialysis patients, they have not been well investigated in scalp hair. In the present study, 22
trace elemental concentrations were measured by inductively coupled plasma-atomic emission spectrometry in the scalp hair
of 80 male hemodialysis patients and compared with those of 100 healthy male subjects. In hemodialysis patients, the concentrations
of beryllium, arsenic, magnesium, chromium, manganese, iron, selenium, molybdenum, iodine, vanadium, and cobalt were significantly
higher than those in healthy subjects, while lead, mercury, copper, germanium, and bromine were significantly lower than those
in the former group. No significant differences were observed for lithium, aluminum, cadmium, zinc, boron, or nickel. There
were significant positive correlations between the duration of hemodialysis and the magnesium and manganese concentrations.
There was a significant negative correlation between cadmium concentration and the duration of hemodialysis. There were significant
positive correlations between dialysis efficacy (Kt/V) and magnesium, manganese, zinc, and selenium concentrations. In conclusion,
trace element concentrations of the scalp hair are different between hemodialysis patients and healthy subjects. Essential
trace elements, such as magnesium, manganese, zinc, and selenium, may be affected by the duration of hemodialysis and Kt/V. 相似文献
9.
E. V. Evstaf’eva O. A. Zalata E. V. Repinskaya I. A. Evstaf’eva M. G. Shchegoleva S. L. Tymchenko N. M. Ovsyannikova 《Neurophysiology》2006,38(2):142-148
In 18-to 19-year-old students, the content of a number of microelements, as well as of calcium, in biologically stable tissues
(hair samples) was measured using X-ray fluorescent analysis. In the tested persons, we observed a certain deficit of main
elements (calcium, copper, and zinc), while in some persons the levels of toxic lead and strontium were exceeded. Correlation
analysis of the parameters of EEG potentials (current EEG and evoked and event-related potentials, EPs and ERPs, respectively)
showed the existence of a few significant (or close to those) correlations of the spectral powers of some rhythms and derivatives
of a few indices of the background EEG and more numerous cases of correlations of the parameters of EPs and ERPs (latencies
and amplitudes) with the contents of the studied elements. The physiological importance of metals, according to the number
of characteristics of EEG potentials that correlate with their contents, can be arranged in descending order as follows: As,
Zn > Ca > Cd > Pb > Sr. None of the studied parameters of EEG phenomena correlated with the level of copper. The strength
of correlations varied from weak to mild (0.29 < R < 0.50). The densest correlations were observed for the concentrations of toxic lead and cadmium. With respect to the characteristics
of ERPs, some of the elements under study demonstrated synergism (e.g., lead and arsenic), while others were in an antagonistic
relation (cadmium and calcium).
Neirofiziologiya/Neurophysiology, Vol. 38, No. 2, pp. 167–174, March–April, 2006. 相似文献
10.
Calcium,magnesium, and other elements in the red blood cells and hair of normals and patients with premenstrual syndrome 总被引:2,自引:0,他引:2
Shamberger RJ 《Biological trace element research》2003,94(2):123-129
This study compared the levels of 18 red cell elements and 22 hair elements in 46 patients (median age: 36.2 yr) diagnosed
with PMS (premenstrual syndrome) to 50 normals (median age: 37.7 yr). Significantly lower amounts of calcium, chromium, copper,
and manganese were found in the blood of patients with PMS. The ratios of Mg/Ca and K/Na and toxic metals such as lead, arsenic,
and germanium were significantly elevated in the PMS patients. In hair, mercury and the Zn/Cu ratio were significantly greater
in the PMS patients than the controls, but iron, potassium, and the Mg/Ca ratio were lower. The highly significant Mg/Ca ratio
in blood cells may be indicative of a more complex relationship between PMS and magnesium and calcium than either element
alone. The significantly lower blood cell calcium level found in these studies may provide additional evidence that PMS may
be related to a calcium-deficiency state or a metabolic defect involving calcium. 相似文献
11.
Shun-Zhi Liu Hong Yan Peng Xu Jian-Ping Li Gui-Hua Zhuang Bo-Feng Zhu She-Min Lu 《Biological trace element research》2009,131(3):205-214
The objective of this paper is to investigate the correlation between serum macro-element and trace element contents and bone
mineral density (BMD) as well as the occurrence of osteoporosis. After the epidemiological investigation of 290 postmenopausal
women from ages 45 to 65 in the Xi’an urban area, their blood was collected and serum concentrations of macro-elements, calcium,
phosphonium, potassium, sodium, magnesium, and trace elements, zinc, iron, copper, and selenium were determined using atomic
absorption spectrometry. Their BMD was measured by QDR-2000 dual-energy X-ray absorptiometry (DEXA). The correlation analysis
between BMD and serum element contents was done with the software of SPSS 13.0. The correlation analysis of serum elements
of postmenopausal women showed that there was a significant correlation between serum calcium and the other elements, and
also a significant correlation between serum phosphonium and the others except serum potassium. The serum potassium content
had a significant correlation with serum calcium, sodium and iron, but sodium content showed a significant correlation with
the others except iron and selenium. In addition, copper had a significant correlation with the others except potassium and
selenium. In correlation analysis between BMD and the elements contents, only did the potassium content show a significant
positive correlation with BMD of lumbar vertebra and proximal femora. The comparison results between osteoporosis group, osteopenia
group, and healthy group showed that there was no significant difference in the element contents between the groups, but there
existed a tendency that potassium content increased with the rise of BMD. There exist significant correlations between the
contents of serum elements such as calcium, phosphonium, sodium, potassium, magnesium, zinc, iron, copper, and selenium, but
no significant differences in these elements contents between the osteoporosis group, osteopenia group, and healthy group.
Serum potassium content shows a significant positive correlation with BMD, suggesting potassium may be involved in the development
of osteoporosis in postmenopausal women. 相似文献
12.
V Karasseva I Sziklai M Ord?gh 《Acta microbiologica Academiae Scientiarum Hungaricae》1977,24(3):175-180
Quantitative determination of the elements potassium, sodium, manganese, magnesium, iron, cobalt and zinc was performed in mycobacteria by neutron activation analysis. Mycobacterium phlei ATCC 19 249 at different phase of growth (4, 8, 13, 23 and 37 days old cultures), and 14 days old Mycobacterium bovis BCG cultures and uninoculated semi-synthetic Sauton culture media were examined. The elements studied could be divided into three groups; sodium, potassium and magnesium could be regarded as major, iron as minor, and zinc, manganese and cobalt as trace elements. M. phlei contained, with the exception of zinc, higher amounts of elements than M. bovis. Other metals (aluminium, antimony, rubidium) could also be detected. 相似文献
13.
Mahavir Singh Poonam Yadav Anshu Sharma V.K. Garg Dinesh Mittal 《Biological trace element research》2017,176(2):305-310
The milk samples from buffaloes of Murrah breed at mid lactation stage, reared at an organised dairy farm, were screened for subclinical mastitis based on bacteriological examination and somatic cell count following International Dairy Federation criteria. Milk samples from subclinical mastitis infected and healthy buffaloes were analysed to evaluate physicochemical alterations in terms of protein, fat, pH, electrical conductivity, chloride, minerals (sodium, potassium and calcium) and trace elements (iron, zinc, copper and selenium). In the present study, protein, fat, zinc, iron, calcium and selenium content was significantly lower (P < 0.001), while pH and electrical conductivity were significantly higher in mastitic milk as compared to normal milk. Concentration of electrolytes mainly sodium and chloride significantly increased with higher somatic cell count in mastitic milk and to maintain osmolality; potassium levels decreased proportionately. Correlation matrix revealed significantly positive interdependences of somatic cell count with pH, electrical conductivity, sodium and chloride. However, protein, fat, calcium and potassium were correlated negatively with elevated somatic cell count in mastitic milk. It is concluded that udder infections resulting in elevated somatic cells may alter the mineral and trace element profile of milk, and magnitude of changes may have diagnostic and prognostic value. 相似文献
14.
Masashi Kato Mayuko Y. Kumasaka Shoko Ohnuma Akio Furuta Yoko Kato Hossain U. Shekhar Michiyo Kojima Yasuko Koike Nguyen Dinh Thang Nobutaka Ohgami Thuy Bich Ly Xiaofang Jia Husna Yetti Hisao Naito Gaku Ichihara Ichiro Yajima 《PloS one》2013,8(6)
Health risk for well drinking water is a worldwide problem. Our recent studies showed increased toxicity by exposure to barium alone (≤700 µg/L) and coexposure to barium (137 µg/L) and arsenic (225 µg/L). The present edition of WHO health-based guidelines for drinking water revised in 2011 has maintained the values of arsenic (10 µg/L) and barium (700 µg/L), but not elements such as manganese, iron and zinc. Nevertheless, there have been very few studies on barium in drinking water and human samples. This study showed significant correlations between levels of arsenic and barium, but not its homologous elements (magnesium, calcium and strontium), in urine, toenail and hair samples obtained from residents of Jessore, Bangladesh. Significant correlation between levels of arsenic and barium in well drinking water and levels in human urine, toenail and hair samples were also observed. Based on these results, a high-performance and low-cost adsorbent composed of a hydrotalcite-like compound for barium and arsenic was developed. The adsorbent reduced levels of barium and arsenic from well water in Bangladesh and Vietnam to <7 µg/L within 1 min. Thus, we have showed levels of arsenic and barium in humans and propose a novel remediation system. 相似文献
15.
Laila A. Nasser 《Saudi Journal of Biological Sciences》2015,22(5):513-520
Several studies have shown that canned meat products may be contaminated with fungal elements, bacteria and even heavy metals which may occur during the transportation, storage and handling processes. We conducted this study to determine the fungal, microbial and heavy metal contents of canned meats in Saudi Arabia. Of the 13 canned meat samples studied, Aspergillus and Penicillium were found in more than 70% of the total samples. Sequences of Penicillium species isolated from meat samples generated a phylogenetic tree which shows that the studied isolates were clustered in four groups. No bacterial contamination was noted in all of the samples. Nine of the 13 samples had iron concentrations above the permissible limit. All samples had zinc and copper levels below the maximum permissible limit. Four samples had cadmium levels above the maximum permissible level. All samples had levels of lead above the maximum permissible levels. These results indicate that fungal elements and higher levels of heavy metals such as lead and cadmium can be found in canned meat products. This may pose as a real danger to consumers, since canned meat products are readily accessible and convenient in Saudi Arabia. 相似文献
16.
Nida Fatima Kolachi Tasneem Gul Kazi Hassan Imran Afridi Naveed Kazi Ghulam Abbas Kandhro Abdul Qadir Shah Jameel Ahmed Baig Sham Kumar Wadhwa Sumaira Khan Faheem Shah Mohammad Khan Jamali Mohammad Balal Arain 《Biological trace element research》2011,143(1):116-130
The aim of the present study was to compare the level of copper (Cu), iron (Fe) and zinc (Zn) in biological samples (serum, blood, urine, and scalp hair) of patients suffering from different viral hepatitis (A, B, C, D, and E; n?=?521) of both gender age ranged 31–45 years. For comparative study, 255 age-matched control subjects, of both genders residing in the same city were selected as referents. The elements in the biological samples were analyzed by flame atomic absorption spectrophotometry, prior to microwave-assisted acid digestion. The validity and accuracy of the methodology was checked by using certified reference materials (CRMs) and with those values obtained by conventional wet acid digestion method on same CRMs. The results of this study showed that the mean values of Cu and Fe were higher in blood, sera, and scalp hair samples of hepatitis patients, while Zn level was found to be lower than age-matched control subjects. The urinary levels of these elements were found to be higher in the hepatitis patients than in the age-matched healthy controls (p?<?0.05). These results are consistent with literature-reported data, confirming that the deficiency of zinc and hepatic iron and copper overload can directly cause lipid peroxidation and eventually hepatic damage. 相似文献
17.
Ziqiang Meng 《Biological trace element research》1998,61(1):79-87
The hair of 1518 healthy subjects between newborn and 70 yr old living in Linfen city and the surrounding rural area in Shanxi
province, North China, was analyzed by means of a flame atomic absorption spectrophotometer method in order to determine the
concentrations of zinc (Zn) and lead (Pb). The collected samples were subdivided on the basis of age, sex, and place of residence
(urban and rural). In female hair, the contents of Zn were higher than in male, but the hair Pb concentrations of males were
slightly higher than those of females. Age seems to have a different influence on the two elements. The maximum amount of
hair Zn was found generally in newborns. From the baby group (<1 yr) to the puberty group (15–19 yr), Zn levels in hair increased
with age, and then Zn levels decreased with age from the puberty group to elderly group (61–70 yr). The hair Pb levels were
the lowest in newborns, increased with age from newborn to infant (1–2 yr), and then decreased with age from infant to the
elderly. It was shown that the hair Pb and Zn levels were inversely related in various age groups, suggesting that there is
possibly antagonism between Pb and Zn in the human body. The results also showed the hair Pb levels of subjects living in
the urban area, except for newborns, were higher than those of subjects residing in the rural area. However, no difference
between the hair Zn contents of the populations residing in urban and rural areas. 相似文献
18.
Evaluation of Essential Trace and Toxic Elements in Scalp Hair Samples of Smokers and Alcohol User Hypertensive Patients 总被引:1,自引:0,他引:1
The incidence of hypertension has been associated to cigarette smoking and consumption of alcohol. In the present study, trace
and toxic elements were determined in scalp hair of patients diagnosed with hypertension who are smokers and habitual alcohol
drinkers living in Dublin, Ireland. These results were compared with age- and sex-matched healthy, nonsmokers, nondrinking
controls. The concentrations of trace and toxic elements were measured by inductively coupled plasma atomic emission spectrophotometer
after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked using certified reference
material (NCS ZC 81002b) and by the conventional wet acid digestion method on the same certified reference material and on
real samples. The recovery of all the studied elements was found to be in the range of 97.5%–99.7% in certified reference
material. The results of this study showed that the mean values of cadmium, copper, iron, nickel and lead were significantly
higher in scalp hair samples of both smoker and nonsmoker hypertensive patients than referents (P < 0.001); whereas, the concentration of zinc was lower in the scalp hair samples of hypertensive patients of both genders.
The deficiency of zinc and the high exposure of trace and toxic metals as a result of cigarette smoking and alcohol consumption
may be synergistic with risk factors associated with hypertension. 相似文献
19.
Pasa S Kargin F Bildik A Seyrek K Ozbel Y Ozensoy S 《Biological trace element research》2003,94(2):141-147
The aim of this study was to determine the zinc, iron, copper, calcium, phosphorus, and magnesium levels in blood serum and
zinc and copper levels in hair of dogs with canine visceral leishmaniasis. The serum zinc and iron levels were found to be
significantly lower in diseased dogs than those of healthy controls. Serum copper levels were significantly higher, whereas
no significant differences were observed for calcium, phosphorus, and magnesium. There were no significant differences in
the zinc and copper levels in hair. Our results show that the serum zinc, iron, and copper levels are altered in canine leishmaniasis. 相似文献
20.
Mineral deficiencies can cause impaired insulin release and insulin resistance. This study was conducted to investigate the relationship between hair mineral concentrations and insulin resistance in patients with metabolic syndrome (MS). A total of 456 subjects (161 patients with MS and 295 subjects without MS) were reviewed, and fasting plasma glucose, triglycerides, HDL-cholesterol, homeostasis assessment model-insulin resistance (HOMA-IR), and hair mineral concentrations were analyzed. While hair sodium and potassium concentrations were significantly higher, the hair calcium, magnesium, and zinc concentrations were lower in the MS group than in the control group. Regarding toxic element measurements, the hair arsenic (As) and lead (Pb) concentrations were higher in the MS group than in the control group. The results of multiple regression analysis, after adjusting for age, showed significant relationships between the Na/Mg and Ca/P ratios and HOMA-IR (R 2?=?0.109, p?<?0.05). The Ca, Na, K, and B concentrations were also associated with HOMA-IR (R 2?=?0.116, p?<?0.05). The hair Na concentration was significantly associated with MS, even after adjusting for age, visceral adipose tissue, and HOMA-IR (OR 1.020; 95 % CI 1.001–1.040; p?=?0.036). Our findings suggest that hair mineral concentrations, such as calcium, magnesium, zinc, sodium, and potassium concentrations, may play a role in the development of insulin resistance. 相似文献