Over de mogelijkheid van intranucleaire kruising bij homozygoten

Ohne Zusammenfassung     

Rivastigmine als ondersteuning bij het dilemma van de behandeling van hallucinaties optredend bij ziekte van Parkinson

We report three cases of patients with Parkinson’s disease without dementia, admitted to our hospital because of hallucinations. The anti-Parkinson medication was adapted and the patients started with rivastigmine. As a result, hallucinations no longer occurred. A 79 years old man also required short-term quetiapine because of agitation and anti-Parkinson doses were without side effects, as a result of which mobility improved. An 84 years old woman reported mild side effects of rivastigmine, without consequences, whereas her mobility appeared to be good. A 72 years old woman reported mild memory problems upon admission, which improved during admission, as did her mobility after increasing the anti-Parkinson medication doses. Treatment of rivastigmine can be useful in the therapeutic dilemma in the treatment of hallucinations in patients with Parkinson’s disease (start anti-psychotic or reduce anti-Parkinson medication). In addition to adapting anti-Parkinson doses and sometimes short-term treating with an anti-psychotic, treatment with rivastigmine appears to be a quick improvement, without serious side effects. Also, mobility can improve, due to the possibility of increasing the anti-Parkinson doses, if necessary. Because of the many remaining questions, prospective randomised trials are needed.     

Over het gebruik van d-glutaminezuur bij het bacteriologische wateronderzoek

Samenvatting In het d-glutaminezuur werd een chemisch zuivere, relatief goedkoope stof gevonden, die het pepton in de voedingsbodems voor het bacteriologische wateronderzoek lijkt te kunnen vervangen; waarmede de moeilijkhedem uit de wereld zouden zijn, die, vooral bij het colionderzoek, kleven aan het gebruik van peptonen van verschillende herkomst. Hoewel het niet mogelijk bleek, de false presumptive tests geheel te vermijden, wordt toch het voordeel groot genoeg geacht om een proefneming op grooteren schaal in waterleidingbedrijven aan te bevelen.Summary The fact is stressed, that in bacteriological wateranalysis many false presumptive tests occur, where B. coli can not be isolated from strongly fermenting tubes. The view is held, that an improvement may be possible, when substituting peptone by a nitrogen compound, that is easily taken by B. coli and not by the organisms causing the false presumptive test. Therefore d-glutamic acid (as a sodium- or ammoniumsalt) is tried and found to be perfectly suitable to grow B. coli, but equally good to the other organisms. Nevertheless glutamic acid has a distinct advantage on peptone, being a chemically pure and relatively cheap substance, so that difficulties, arising from the use of different brands of commercial peptones, of unknown composition, may be avoided. Investigation of natural waters, using a solution of 1 % lactose, 1 % glutamic acid, 0.1% K₂HPO₄ and 0.05 % MgSO₄ in distilled water, coloured with bromo thymol blue and neutralised with sodium hydroxide to p₄ 7.0, gives the same results as the same liquid, wherein peptone (Witte) substitutes the glutamic acid. Further experience will have to decide on its suitability in large scale practice.     

Palliatieve zorg bij dementie en de ontmanteling van de behandelfunctie van het verpleeghuis

Palliative care in dementia and the dismantlement of nursing home medicinePalliative care is mostly restricted to the terminal phase of incurable illness. According to the WHO revised definition palliative care is specifically directed towards patients and families facing life-threatening illness. This definition is not adequate to orient and direct palliative care policies in non-cancer diseases such as dementia. Although dementia is incurable from the outset, its course is often protracted, resulting in a terminal stage only after several years. This disease trajectory necessitates an alternative palliative approach, implying a proactive attitude of nursing home physicians in facilitating early and timely discussions with patients and their proxies on advance care planning and treatment of complications and concomitant diseases. This, together with their specific training in the treatment of the long term sequelae of chronic diseases, defines the success of Dutch nursing home medicine in foregoing inappropriate hospital admissions and providing adequate medical care in the nursing home. However, recent reorganisations of nursing home care and its funding threaten to downgrade the quality of medical care for patients with dementia in Dutch nursing homes by focusing unilaterally on welfare ideology and ‘marketization’ of long term care, thus underestimating the importance of a palliative care policy in dementia.     

Het mechanisme van de schadelijke werking van atmospherische zuurstof op de groei van anaerobe bacillen

Samenvatting Op grond van theoretische overwegingen meende schrijver te mogen verwachten, dat anaerobe bacillenniet in benzidinebouillon,niet in bloedbouillon dochwel in benzidine-bloedbouillon gedurende herhaalde passages zouden kunnen worden voortgekweekt. Dit blijkt inderdaad het geval te zijn. Dit pleit voor de hypothese vanM'Leod en Gordon, dat de obligate anaerobie der anaerobe bacillen berust op hun vorming van peroxyde, terwijl zij voor die stof uitermate gevoelig zijn en bij gebrek aan katalase of peroxydase deze niet onschadelijk kunnen maken. De combinatie van bloed en benzidine bezit dit vermogen om peroxyde te verwerken in hooge mate; vandaar dat zij samen den groei van anaerobe bacillen aan de vrije atmospheer mogelijk maken. De proeven vanGoldie, die anaerobe bacillen in aerobe zou hebben omgekweekt, werden niet bevestigd. Summary The author expressed the opinion that on theoretical considerations he expected that anaerobe bacilli would not be bred in benzidine-bouillon, nor in blood-bouillon, but would continue to be bred in benzidine-blood-bouillon during repated passages. This, as a matter of fact, proves to be the case. This speaks well for the hypothesis ofM'Leod and Gordon that the obligate anaeroby of the anaerobe bacilli is based on their producing peroxyde, whereas they are extremely sensitive to this substance and by lack of catalase or peroxydase are unable to render this harmless. The combination of blood and benzidine has this power to assimilate peroxyde in a high degree; hence it is possible that together they permit the culture of anaerobe bacilli in open containers. The experiments of Goldie, who is said to have converted anaerobe bacilli into aerobe, have not been confirmed. Voordracht gehouden voor de vergadering der Ned. Vereen. voor Microbiol. op 5 Mei 1934 te Baarn.     

Bijdragen tot de kennis van enkele Hollandsche groente-erwten. I.

Summary Several crosses werer made between some races of peas frequently grown in Holland for culinary purposes. Of these Blauwpeul is a large brown seeded pea with indent seeds. It has pigment in its testa, but does not possess the factor for spots.Krombek, a pea with curved pods, yellow cotyledons and pigmentless testa possesses this factor for spots; thus the cross Krombek x Blauwpeul gives spotted seeds in the F₁.Kroonerwt, a green pea with big globular seeds has also the spto factor, but American Wonder, green with wrinkled seeds, has not. Low Cape Capucin has small spotted seeds of indent shape. Crossed with American Wonder it gives rise to all kinds of peas, but a remarkable fact in all crosses mentioned is, that where pigment is present in the testa, the form of the seeds always is indent. Pure wrinkled and globular seeds have colourless testa.The factor for indent is hyperstatic over globular.