唐古特瑞香的化学成分研究

从唐古特瑞香(Daphne tangutica Maxim)95%乙醇提取物石油醚部分分离得到14个化合物,通过波谱学方法鉴定为β-谷甾醇(1)、β-胡萝卜苷(2)、2,4-二羟基-3,6-二甲基苯甲酸甲酯(3)、蛇床子素(4)、植物醇(5)、软脂酸(6)、stigmast-5-ene-3β,7α-diol(7)、(-)-lariciresinol(8)、daphnetin(9)、daphnoretin(10)、(-)-丁香树脂醇(11)、( )-medioresinol(12)、daphnelicin(13)和咖啡酸二十二酯(14)。     

水麻的化学成分研究(英文)

从水麻(Debregeasia orientalis C J Chen)地上部分的95%乙醇提取物中首次分离到18个化合物,应用波谱方法或与已知品对照的手段鉴定它们为棕榈酸 (1)、正二十烷酸 (2)、正二十烷酸甲酯 (3)、β-谷甾醇 (4)、Monogynol A (5)、白桦酸 (6)、Hederagenin (7)、β-胡萝卜甙 (8)、18αH-20(29)-烯-3-酮-乌苏烷 (9)、3,4-开环-20(29)-烯-乌苏烷-3-酸 (10)、Pomolic acid (11)、表儿茶素 (12)、儿茶素 (13)、槲皮素 (14)、槲皮素-3-O-β-D-吡喃葡萄糖苷 (15)、紫丁香苷 (16)、紫丁香酚苷 (17)和山萘酚-3-O-β-D-芦丁糖苷 (18).     

菊科植物的杀菌活性及其活性成分

本文对菊科16个属———刺苞果属(Acanthospermum)、蓍属(Achillea)、胜红蓟属(Ageratum)、蒿属(Arte-misia)、紫苑属(Aster)、Balsamorhiza、雏菊属(Bellis)、鬼针草属(Bidens)、艾纳香属(Blumea)、天明精属(Carpe-sium)、红花属(Carthamus)、矢车菊属(Centaurea)、茼蒿属(Chrysanthemum)、菊苣属(Cichorium)、秋英属(Cos-mos)、大丽花属(Dahlia)中具有杀菌活性的植物按属的顺序进行了综述.表明在16个属中主要杀菌植物集中在蓍属(Achillea)、胜红蓟属(Ageratum)、蒿属(Artemisia)、天明精属(Carpesium)和矢车菊属(Centaurea)等5个属中,为进一步开展菊科植物资源的植物性杀菌剂研究和开发利用提供参考.     

紫金龙的生物碱成分研究

从云南白族药物紫金龙(Dactylicapnos scandens)中分离得到了11个生物碱,分别鉴定为6-acetonylsan-guinarine(1)、7-hydroxy-dehydroglaucine(2)、demethylsonodione(3)、dihydrosanguinarine(4)、isocorydione(5)、glaucine(6)、N-methylisocorydine(7)、isocorydine(8)、protopine(9)、magnoflorine(10)和haitinosporine(11).其中化合物1～5,7,10～11为首次从该植物中分离得到.     

银杏落叶化学成分研究

采用硅胶与Sephadex LH-20柱色谱等手段从银杏落叶中分离得到22个化合物,通过理化性质和波谱数据分别鉴定为白果醇(1)、二十八烷酸(2)、棕榈酸(3)、三十七烷(4)、二十四烷(5)、4,10-二十九烷二醇(6)、β-谷甾醇(7)、胡萝卜苷(8)、银杏内酯A(9)、银杏内酯B(10)、银杏内酯C(11)、白果内酯(12)、对羟基苯甲酸(13)、莽草酸(14)、芫花素(15)、芹菜素(16)、银杏素(17)、异银杏素(18)、金松双黄酮(19)、白果黄素(20)、芦丁(21)和甘露醇(22),其中化合物2、4～6和22为首次从该种植物中分离得到,这些研究为银杏落叶及银杏资源的综合利用奠定了基础。     

海南岛蕨类植物新资料

记录海南蕨类植物新分布15种,这15种植物是毛叶粉背蕨(Aleuritopteris squamosa)、光脚短肠蕨(Allantodia deoderleinii)、淡绿短肠蕨(Allantodia virescens)、台湾车前蕨(Antrophyum formosanum)、岭南铁角蕨(Asplenium sampsonii)、薄叶阴地蕨(Botrychium daucifolium)、黑足鳞毛蕨(Dryopteris fuscipes)、太平鳞毛蕨(Dryopteris pacifica)、爪哇鳞始蕨(Lindsaeajavanensis)、黑鳞剑蕨(Loxogramme assimilis)、网脉海金沙(Lygodium subareolatum)、三轴凤尾蕨(Pteris longipes)、翠绿凤尾蕨(Pteris longipinnula)、布郎卷柏(Selaginella braunii)和高雄卷柏(Selaginella repanda)。海南现有蕨类植物已达到约450种(包括变种)。     

疏花卫矛化学成分的研究

从疏花卫矛(Euonymus laxiflorus Champ. ex Benth.)树皮的乙醇提取物中分离得到14个化合物,通过波谱分析(NMR、MS、IR等),鉴定其结构分别为：羽扇豆醇 (1)、木栓酮 (2)、羽扇豆酮 (3)、3-羟基-4-甲氧基苯甲醛 (4)、东莨菪内酯 (5)、(+)-松脂醇 (6)、(-)-Isoyatein (7)、4-羟基-3-甲氧基肉桂醛 (8)、京尼平苷酸 (9)、胆甾醇 (10)、(8R,8′R,9R)-cubebin (11)、(8R,8′R,9S)-cubebin (12)、4-羟基-3,5-二甲氧基肉桂醛 (13)、二十六碳酸 (14)。化合物1～14均为首次从该植物中分离得到。     

深水网箱养殖卵形鲳鲹血液指标

对深水网箱养殖卵形鲳鲹(Trachinotus ovatus)成鱼的部分血液性状和血清生化指标进行测定比较.结果显示,雌、雄成鱼红细胞数量(RBC)、白细胞数量(WBC)、血细胞比容(Ht)、红细胞沉降率(ESR)等血液性状不存在显著性差异.血清指标中雌、雄成鱼血糖(GLU)的含量分别为(10.24±1.25)mmol/L、(17.36±1.34)mmol/L,存在极显著差异;雌鱼血清中低密度脂蛋白胆固醇(LDL-C)、钾离子(K+)、谷丙转氨酶(ALT)、谷草转氨酶(AST)浓度大于雄鱼(P<0.05);雄鱼血清中肌酐(CREA)、钠离子(Na+)浓度大于雌鱼(P<0.05);尿酸(UA)、尿素氮(BUN)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、γ-谷氨酰转肽酶(γ-GT)、总蛋白(TP)、白蛋白(ALB)、球蛋白(GLB)、白蛋白/球蛋白(ALB/GLB)、钙离子(Ca2+)、氯离子(Cl-)、无机磷(PO43-)等指标,雌雄差异不显著.卵形鲳鲹部分生化指标存在雌雄差异,可能与个体的生理状况有关.结果可为卵形鲳鲹血液生理研究提供基础资料.     

中华山蓼化学成分研究

bk中华山蓼(Dxyria sinensis Hemsl.)全草中首次分离得到十四个化合物,通过波谱学方法分别鉴定为(-)-表没食子儿茶素(1)、(-)-儿茶素没食子酸酯(2)、(-)-表儿茶素(3)、(-)-表儿茶素-3-没食子酸酯(4)、槲皮素-3-O-α-L-鼠李糖苷(5)、tiliroside(6)、山萘酚-3-O-β-D-吡喃葡萄糖苷(7)、桷皮素(8)、2,4-二羟基-6-甲氧基-乙酰基苯-4-O-β-D-吡喃葡萄糖苷(9)、反-N-(4-羟基苯乙基)阿魏酸酰胺(10)、顺-N-(4-羟基苯乙基)阿魏酸酰胺(11)、icariol A2(12)、(+)-松脂素(13)、Helonioside B(14).     

中草药玄参化学成分的研究

从中草药玄参Scrophularia ningpoensis Hemsl.的乙醇溶液中分离得到14个化合物,根据理化性质和光谱数据分析分别鉴定为柳杉酚(1)、β-谷甾醇(2)、羽扇豆醇(3)、熊果酸(4)、鼠李糖(5)、胡萝卜苷(6)、蔗糖(7)、咖啡酸(8)、油酸(9)、3-O-(6’-O-palmitoyl-β-D-glucosyl)-spinasta-7,22-diene(10)、clematomanshurica saponin E(11)、α-caryphy(12)、雪松醇(13)和Scrophuloside A4(14)。其中化合物3,58,～14均为首次从玄参中分离得到。     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.