小叶臭黄皮的黄酮苷甙成分

从云南西双版纳的小叶臭黄皮（Clausena excavata Burm.f.）中分离到一个新黄酮甙,5,7,5′－三羟基－3′,4′－二甲氧基黄酮3－0－α－L－吡喃鼠李糖甙（1）和4个已知黄酮甙,分别为5,7,3′,5′－四羟基－4′－甲氧基黄酮3－O－α－L－吡喃鼠李糖甙（2）,5,7,3′－三羟基－4′－甲氧基黄酮3－O－α－L－吡喃鼠李糖甙（3）,5,7,4′－三羟基－3′,5′－二甲氧基黄酮3－O－α－L－吡喃鼠李糖甙（4）,5,7,4′－三羟基黄桐3－O－α－L－吡喃鼠李糖甙（5）。根据HMQC、HMBC实验修正了化合物2－5C6和C8的位碳化学位移的归属。     

密花香薷的化学成分

从密花香薷 (Elsholtzia densa Benth.)中分得 10个化合物 ,经波谱分析和化学方法鉴定为 :二十九碳烷 (1)、丁二酸 (2 )、5- (3″,3″-二甲基烯丙基 ) - 8-甲氧基呋喃香豆素 (3)、5- (3″-甲基丁基 ) - 8-甲氧基呋喃香豆素 (4)、5- (3″-羟基 - 3″-甲基丁基 ) - 8-甲氧基呋喃香豆素 (5)、3,4-二羟基肉桂酸 (6)、5-羟基 - 3′-甲氧基双氢黄酮 - 7- O-芸香糖甙 (7)、槲皮素 - 3- O- β- D-葡萄糖甙 (8)、山奈素 - 3- O- β- D-葡萄糖甙 (9)、5-羟基 - 4′-甲氧基黄酮 - 7- O-芸香糖甙 (10 )。其中 ,化合物 4和 5是新的天然产呋喃香豆素。     

黄杨中的非生物碱化学成分

从黄杨Buxus sinica地上部分分离出10个化合物,通过光谱分析鉴定为：Cleomiscosin A（1）,3,5-二羟基-4′,6,7-三甲氧基-黄酮-3′-O-β-D-葡萄糖甙（2）,5,3′,4′-三羟基-3,6,7-三甲氧基-黄酮（3）,Cleomiscosin A-4′-O-β-D-glucopyranoside（4）,3,5-二甲氧基苯甲酸-4-O-β-D-葡萄糖甙（5）,4′,5-二羟基-3,6,7-三甲氧基-黄酮（6）,羽扇豆烷醇（7）,（＋）-Pinoresinol-O-β-D-glucopyranoside（8）,β-谷甾醇（9）,胡萝卜甙（10）。其中化合物1—5,6,8均为首次从该属植物中分离得到。     

圆穗蓼中的新黄酮甙成分

从圆穗蓼（Ｐｏｌｙｇｏｎｕｍ ｓｐｈａｅｒｏｓｔａｃｈｙｕｍ Ｍｅｉｓｎ．）中分离得到２个新黄酮甙,经光谱分析和化学方法鉴定为：３＇－羟基－５,４＇－二甲氧基－６,７－二氧亚甲基黄酮－３－Ｏ－「β－Ｄ－吡喃木糖基（１→６）」－β－Ｄ－吡喃葡萄糖甙⑴和５,４＇－二甲氧基－３＇－异丙烯基乙酰基－６,７－二氧亚甲基黄酮－３－Ｏ－「β－Ｄ－吡喃木糖基（１→６）－β－Ｄ－吡喃葡萄糖甙⑵,分别命名为圆穗蓼素Ａ     

小叶黄杨化学成分的研究

小叶黄杨氯仿组分通过硅胶柱色谱分离纯化,从中分离得到9个化合物,分别鉴定为:β-谷甾醇(β-Sitosterol,Ⅰ)、豆甾醇(Stigmasterol,Ⅱ)、胡萝卜甙(daucosterol,Ⅲ)、水杨酸(salicylis acid,Ⅳ)、香草酸(vanillicacid,Ⅴ)、5,4′-二羟基-3,3′,7-三甲氧基-黄酮(5,4′-dihydroxy-3,3′,7-trimethoxy-flavone,Ⅵ)、5,4′-二羟基-3,3′,6,7-四甲氧基-黄酮(5,4′-dihydroxy-3,3′,6,7-tetramethoxy-flavone,Ⅶ)、Cleomiscosin A(Ⅷ)、3,5-二羟基-4′,6,7-三甲氧基-黄酮-3′-O-β-D-葡萄糖甙(3,5-dihydroxl-4′,6,7-trimethoxyl-flavone-3′-O-β-D-glucopyranoside,Ⅸ),其中化合物Ⅳ、Ⅴ、Ⅵ、Ⅶ均首次从该属植物中分离得到。     

厚果鸡血藤的化学成分研究

继厚果鸡血藤化学成分的研究（Ⅰ）、（Ⅱ）之后,又从厚果鸡血藤Millettia pachycar pa Benth。根部分离得到多个化合物,经理化分析和波谱分析,确定了其中七个黄酮类化合物的结构为3,3′,4′5′－四甲氧基呋喃[4^∥,5^∥：8,7]黄酮（Ⅰ）,3,3′－二甲氧基呋喃[4^∥,5^∥：8,7]黄酮（Ⅱ）,2,3－二甲氧基呋喃[4′,5′：11,10]－7－氧代[2]苯吡喃[4,3－b][1]－苯吡喃（Ⅲ）,呋喃[4^∥,5^∥：8,7]黄酮（Ⅳ,Lanceolatin B),3-甲氧基－2^∥,2^∥-二甲基吡喃[5^∥,6^∥：8,7]黄酮（Ⅴ）,5－甲氧基呋喃[4^∥,5^∥：7,6]黄酮（Ⅵ,pinnatin）,2^∥,2^∥-二甲基吡喃[5^∥,6^∥：8,7]黄烷酮（Ⅷ,（-）-isolonchocarpin）。这七个化合物皆为首次从该植物中分离得到,其中化合物Ⅰ,Ⅱ,Ⅲ为新的化合物,分别命名为厚果鸡血藤丙素（pachycarin C)、厚果鸡血藤丁素（pachycarin D)和厚果鸡血藤戊素（pachycarin E）。     

艾纳香黄酮类化学成分的研究(英文)

从艾纳香(Blumea balsamiferaDC.)的地上部分中分离得到13个黄酮类化合物,经鉴定分别为5,7-二羟基-3,3′,4′-三甲氧基黄酮(1),3,5,3′,4′-四羟基-7-甲氧基黄酮(2),4,2′,4′-三羟基双氢查尔酮(3),儿茶素(4),阿亚黄素(5),davidioside(6),二氢槲皮素-7,4′-二甲醚(7),艾纳香素(8),二氢槲皮素-4′-甲醚(9),3,5,3′-三羟基-7,4′-二甲氧基黄酮(10),5,7,3′,5′-四羟基二氢黄酮(11),木犀草素(12),槲皮素(13)。其中化合物1和3~6为首次从该植物中分离得到。     

灯盏花中的糖苷

从灯盏花（Erigeron breviscapus (Vant.) Hand.-Mazz.) 全株的乙醇提取物的正丁醇部分分得10个化合物,通过波谱方法鉴定为erigeside I(1)、γ－吡喃酮－3－O－β－D－[6′－（4″－羟基－3″,5″－二甲氧基苯甲酰）-]-吡喃葡萄糖苷（erigeside D,2)、erigeside A(3)、erigeside B(4)、erigeside Ⅱ(5)、7-O-β-D-吡喃葡萄糖－6－甲氧基香豆素（6）、icariside B2(7)、blumenol C葡萄糖苷（8）、（＋）－丁香树酯醇O－β－D－吡喃葡萄糖苷（9）和野黄芩苷甲酯（10）。用X射线单晶衍射方法确定了化合物7的绝对构型。2是一个新化合物,7、8和9首次从该属植物分离得到,6首次从该种植物分离得到。     

艾纳香化学成分的研究

从艾纳香(Blumea balsamifera DC.)中分离得到12个化合物,通过理化性质和波谱数据分析分别鉴定为;商路素(1),花椒油素(2),2,4-二羟基-6-甲氧基苯乙酮(3),5,7-二羟基色原酮(4),金丝桃苷(5),异槲皮苷(6),3′,4′,5,7-四羟基-3-甲氧基黄酮(7),槲皮素(8),槲皮素-3′-甲氧基-3-O-β-D-半乳吡喃糖苷(9),4′,5,7-三羟基-3,3′-二甲氧基黄酮(10),3,5,7-三羟基-3′,4′-二甲氧基黄酮(11),木犀草素(12).其中,化合物3-7和9- 11为首次从该属植物中分离得到.     

攀枝花苏铁叶中的一个新黄酮碳甙

从攀枝花苏铁(Cycas panzhihuaensis L. Zhou et S. Y. Yang)叶中分离出6个化合物,其中1个为新黄酮碳甙,命名为攀枝花苏铁甙(1),其结构通过波谱解析和化学降解得以确定.其余化合物分别鉴定为2,3-二氢偏柏黄酮(2)、 5,5″,7,7″,4′,4-六羟基-(2′,8″)-双黄酮(3)、香草酸(4)、β-谷甾醇(5)和胡萝卜甙(6).     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.     

肝癌中HBV和HCV基因和抗原的分布及意义

采用原位分子杂交方法检测HCV RNA及HBV X基因;采用免疫组织化学方法研究HCV核心抗原,非结构区C33c抗原及HBxAg在肝细胞肝癌中的定位及分布.结果表明(1)HCV RNA、HBV X基因在肝细胞肝癌组织检出率分别为40%(55/136)和82%(112/136).HCV RNA定位于癌细胞的胞浆内,阳性细胞呈散在、灶状及弥漫分布三种形式;HBV X基因在肝癌细胞中的分布呈胞浆型、核型及核浆型,阳性细胞也呈上述三种分布形式;(2)HCV C33c抗原、核心抗原在肝细胞肝癌中的阳性率为81%(133/164)及86%(141/164).C33c抗原定位于癌细胞及肝细胞的胞浆内;核心抗原既定位于癌细胞核中,又可定位于胞浆中.C33c抗原阳性细胞以灶状分布为主;而核心抗原阳性细     

Selection with two alleles and complete dominance

For a plant selection model with frequency-independent viabilities, fertilities and selfing rates, it is shown that apart from global fixation, for certain parameter combinations a protected polymorphism and facultative fixation (either allele may become fixed according to initial frequencies) may both occur. Facultative fixation requires different selling rates for the dominant and recessive type. Protection of the polymorphism requires resource allocation for male and female function. In this connection the problem of purely genetically caused population extinction is discussed.
For general frequency dependence and regular segregation, the chances for establishment of a completely recessive gene are compared to those of a completely dominant gene. It is proven that the process of establishment of the recessive gene, despite a fitness advantage, may be considerably endangered by drift effects if random mating prevails. The recessive gene may reach the same effectivity in establishment as a dominant gene, only if the recessive homozygote mates exclusively with its own type during the period of establishment.