共查询到20条相似文献,搜索用时 109 毫秒
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Jenher Lu Tzuchun Tsai Sielin Choo Shuyu Yeh Renbing Tang Anhang Yang Hsinyu Lee Jennkan Lu 《Journal of biomedical science》2011,18(1):73
Background
The tbx5 mutation in human causes Holt-Oram syndrome, an autosomal dominant condition characterized by a familial history of congenital heart defects and preaxial radial upper-limb defects. We report aberrant apoptosis and dormant cell growth over head, heart, trunk, fin, and tail of zebrafish embryos with tbx5 deficiency correspond to the dysmorphogenesis of tbx5 morphants. 相似文献2.
Kim E Haworth Surendra Kotecha Timothy J Mohun Branko V Latinkic 《BMC developmental biology》2008,8(1):74
Background
GATA factors 4/5/6 have been implicated in the development of the heart and endodermal derivatives in vertebrates. Work in zebrafish has indicated that GATA5 is required for normal development earlier than GATA4/6. However, the GATA5 knockout mouse has no apparent embryonic phenotype, thereby questioning the importance of the gene for vertebrate development. 相似文献3.
Jorg Brunner Nina Scheres Nawal B El Idrissi Dong M Deng Marja L Laine Arie J van Winkelhoff Wim Crielaard 《BMC microbiology》2010,10(1):5
Background
Periodontitis is a bacterial infection of the periodontal tissues. The Gram-negative anaerobic bacterium Porphyromonas gingivalis is considered a major causative agent. One of the virulence factors of P. gingivalis is capsular polysaccharide (CPS). Non-encapsulated strains have been shown to be less virulent in mouse models than encapsulated strains. 相似文献4.
Trond Brattelid Lisbeth H Winer Finn Olav Levy Knut Liestøl Ole M Sejersted Kristin B Andersson 《BMC molecular biology》2010,11(1):22
Background
Quantitative real-time RT-PCR (RT-qPCR) is a highly sensitive method for mRNA quantification, but requires invariant expression of the chosen reference gene(s). In pathological myocardium, there is limited information on suitable reference genes other than the commonly used Gapdh mRNA and 18S ribosomal RNA. Our aim was to evaluate and identify suitable reference genes in human failing myocardium, in rat and mouse post-myocardial infarction (post-MI) heart failure and across developmental stages in fetal and neonatal rat myocardium. 相似文献5.
Huiping Zhu Robert M Cabrera Bogdan J Wlodarczyk Daniel Bozinov Deli Wang Robert J Schwartz Richard H Finnell 《BMC developmental biology》2007,7(1):128
Background
Heart anomalies are the most frequently observed among all human congenital defects. As with the situation for neural tube defects (NTDs), it has been demonstrated that women who use multivitamins containing folic acid peri-conceptionally have a reduced risk for delivering offspring with conotruncal heart defects [1–3]. Cellular folate transport is mediated by a receptor or binding protein and by an anionic transporter protein system. Defective function of the Folr1 (also known as Folbp1; homologue of human FRα) gene in mice results in inadequate transport, accumulation, or metabolism of folate during cardiovascular morphogenesis. 相似文献6.
c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland
Background
The oncoprotein c-Myc has been intensely studied in breast cancer and mouse mammary tumor models, but relatively little is known about the normal physiological role of c-Myc in the mammary gland. Here we investigated functions of c-Myc during mouse mammary gland development using a conditional knockout approach. 相似文献7.
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Rehab Kamel Simone Garcia Frank Lezoualc'h Rodolphe Fischmeister Sylviane Muller Johan Hoebeke Pierre Eftekhari 《BMC developmental biology》2007,7(1):34
Background
The presence of functional 5-HT4 receptors in human and its involvement in neonatal lupus erythematosus (NLE) have prompted us to study the receptor expression and role during embryogenesis. Earlier we managed to demonstrate that female BALB/c mice immunized against the second extracellular loop (SEL) of the 5-HT4 receptor gave birth to pups with heart block. To explain this phenomenon we investigated the expression of 5-HT4 receptors during mouse embryogenesis. At the same time we looked whether the consequence of 5-HT4 receptor immunomodulation observed earlier is in relation to receptor expression. 相似文献10.
Han-Hsin Chang Bo-Yie Chen Chia-Yung Wu Zih-Jay Tsao Ying-Yu Chen Chin-Pao Chang Chi-Rei Yang David Pei-Cheng Lin 《Journal of biomedical science》2011,18(1):6
Background
Hedgehog signalling has been implicated in prostate tumorigenesis in human subjects and mouse models, but its effects on transforming normal basal/stem cells toward malignant cancer stem cells remain poorly understood. 相似文献11.
Background
Electrocardiography remains the best diagnostic tool and therapeutic biomarker for a spectrum of pediatric diseases involving cardiac or autonomic nervous system defects. As genetic links to these disorders are established and transgenic mouse models produced in efforts to understand and treat them, there is a surprising lack of information on electrocardiograms (ECGs) and ECG abnormalities in neonate mice. This is likely due to the trauma and anaesthesia required of many legacy approaches to ECG recording in mice, exacerbated by the fragility of many mutant neonates. Here, we use a non-invasive system to characterize development of the heart rate and electrocardiogram throughout the growth of conscious neonate FVB/N mice. 相似文献12.
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Background
Testicular development is arrested in the hypogonadal (hpg) mouse due to a congenital deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) synthesis. Chronic treatment of male hpg mice with estradiol induces FSH synthesis and secretion, and causes testicular maturation and qualitatively normal spermatogenesis. As estradiol negative feedback normally inhibits FSH production in the male, this study tested whether this paradoxical response to estradiol in the male hpg mouse might be due to inadequate masculinisation or incomplete defeminization in the neonatal period. Previous studies have demonstrated that treatment of hpg mice with testosterone propionate in the immediate neonatal period is necessary to allow full reproductive behaviors to be expressed following suitable endocrine stimulation at adult ages. 相似文献14.
Kenji Moriyama Atsuko Hanai Kazuyuki Mekada Atsushi Yoshiki Katsueki Ogiwara Atsushi Kimura Takayuki Takahashi 《Journal of biomedical science》2011,18(1):60
Background
The endopeptidase encoded by Phex (phosphate-regulating gene with homologies to endopeptidases linked to the X chromosome) is critical for regulation of bone matrix mineralization and phosphate homeostasis. PHEX has been identified from analyses of human X-linked hypophosphatemic rickets and Hyp mutant mouse models. We here demonstrated a newly established dwarfism-like Kbus/Idr mouse line to be a novel Hyp model. 相似文献15.
Bernhard Aigner Birgit Rathkolb Martina Klempt Sibylle Wagner Dian Michel Martin Hrabé de Angelis Eckhard Wolf 《Journal of biomedical science》2009,16(1):53-7
Background
Clinical chemical blood analysis including plasma electrolytes is routinely carried out for the diagnosis of various organ diseases. Phenotype-driven N-ethyl-N-nitrosourea (ENU) mouse mutagenesis projects used plasma electrolytes as parameters for the generation of novel animal models for human diseases. 相似文献16.
Darren A Hooks 《Biomedical engineering online》2007,6(1):21
Background
Computer models of the electrical and mechanical actions of the heart, solved on geometrically realistic domains, are becoming an increasingly useful scientific tool. Construction of these models requires detailed measurement of the microstructural features which impact on the function of the heart. Currently a few generic cardiac models are in use for a wide range of simulation problems, and contributions to publicly accessible databases of cardiac structures, on which models can be solved, remain rare. This paper presents to-date the largest database of porcine left ventricular segment microstructural architecture, for use in both electrical and mechanical simulation. 相似文献17.
Hans Koch Ralf-Dieter Bousseljot Olaf Kosch Cosima Jahnke Ingo Paetsch Eckart Fleck Bernhard Schnackenburg 《Biomedical engineering online》2011,10(1):11
Background
The evaluation, verification and comparison of different numerical heart models are difficult without a commonly available database that could be utilized as a reference. Our aim was to compile an exemplary dataset. 相似文献18.
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