Contents of volume 16, 2006

EOITORIALA journey to a brighter futureGang Pei尺石功石的呀3 GATA·3PromotesTh2resPonsesthroughthreedifferentmeehanisms:inductionofThZeytokine Production,Selective growth of ThZ cells and inhibition of Thl eell·sPecific怕etors Jinfang Zhu,刀友论hiro Yamane,Javiel’ Cole一Sierra.Liying Guo,川llia脚E Paul1 1 The quantal theory of immunity 人治ndallA肠力ith20 Cytokines as critieal eo·stimulatory moleeules in modulating the immune resPonse of natural k川6F C6!!S Howa)汀A Young,…     

2006 International Charr Symposium, Reykjavik, Iceland

The most recent in the continuing series of international conferences dedicated to charrs, Salvelinus species, was held in Reykjavik, Iceland 1–5 August 2006.     

Research on mitochondria and aging, 2006-2007

This review focuses on some of the 'hot topics' that fall under the general heading 'mitochondria and aging'. For each selected topic, we highlight recent publications that have either addressed specific problems within the field or presented novel findings of interest regarding the links between mitochondria and aging. These include studies on the structure of complex I and the mechanisms of superoxide production by this complex; work showing a novel site of hydrogen peroxide production within mitochondria that is modulated by caloric restriction; explorations of the relationship between the rate of evolution of mitochondrial DNA and lifespan; a demonstration that mitochondrial DNA mutations do not limit lifespan in mice; and investigations of the effects of mitochondrial fission on aging. We also list other relevant articles of interest and suggest some key challenges for the field in the near future.