共查询到20条相似文献，搜索用时 15 毫秒
1.
Background
The mechanism by which the signals are transmitted between receptor and effector domains in multi-domain signaling proteins is poorly understood. 相似文献2.
Background
Automatic protein modelling pipelines are becoming ever more accurate; this has come hand in hand with an increasingly complicated interplay between all components involved. Nevertheless, there are still potential improvements to be made in template selection, refinement and protein model selection. 相似文献3.
Seon-Young Kim 《BMC bioinformatics》2009,10(1):147
Background
Few overlap between independently developed gene signatures and poor inter-study applicability of gene signatures are two of major concerns raised in the development of microarray-based prognostic gene signatures. One recent study suggested that thousands of samples are needed to generate a robust prognostic gene signature. 相似文献4.
Background
Oligonucleotide probes that are sequence identical may have different identifiers between manufacturers and even between different versions of the same company's microarray; and sometimes the same identifier is reused and represents a completely different oligonucleotide, resulting in ambiguity and potentially mis-identification of the genes hybridizing to that probe. 相似文献5.
Jens B Andersen Bent B Roldgaard Ariel B Lindner Bjarke B Christensen Tine R Licht 《BMC microbiology》2006,6(1):86-8
Background
Existing virulence models are often difficult to apply for quantitative comparison of invasion potentials of Listeria monocytogenes. Well-to-well variation between cell-line based in vitro assays is practically unavoidable, and variation between individual animals is the cause of large deviations in the observed capacity for infection when animal models are used. 相似文献6.
Background
Geminiviruses (family Geminiviridae) are small single-stranded (ss) DNA viruses infecting plants. Their virion morphology is unique in the known viral world – two incomplete T = 1 icosahedra are joined together to form twinned particles. Geminiviruses utilize a rolling-circle mode to replicate their genomes. A limited sequence similarity between the three conserved motifs of the rolling-circle replication initiation proteins (RCR Reps) of geminiviruses and plasmids of Gram-positive bacteria allowed Koonin and Ilyina to propose that geminiviruses descend from bacterial replicons. 相似文献7.
8.
Background
Amino acids in proteins are not used equally. Some of the differences in the amino acid composition of proteins are between species (mainly due to nucleotide composition and lifestyle) and some are between proteins from the same species (related to protein function, expression or subcellular localization, for example). As several factors contribute to the different amino acid usage in proteins, it is difficult both to analyze these differences and to separate the contributions made by each factor. 相似文献9.
Invasion lags: The stories we tell ourselves and our inability to infer process from pattern 
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下载免费PDF全文 Aim
Many alien species experience a lag phase between arriving in a region and becoming invasive, which can provide a valuable window of opportunity for management. Our ability to predict which species are experiencing lags has major implications for management decisions that are worth billions of dollars and that may determine the survival of some native species. To date, timing and causes of lag and release have been identified post hoc, based on historical narratives.Location
Global.Methods
We use a simple but realistic simulation of population spread over a fragmented landscape. To break the invasion lag, we introduce a sudden, discrete change in dispersal.Results
We show that the ability to predict invasion lags is minimal even under controlled circumstances. We also show a non‐negligible risk of falsely attributing lag breaks to mechanisms based on invasion trajectories and coincidences in timing.Main conclusions
We suggest that post hoc narratives may lead us to erroneously believe we can predict lags and that a precautionary approach is the only sound management practice for most alien species.10.
Sara Magalhães Elodie Blanchet Martijn Egas Isabelle Olivieri 《BMC evolutionary biology》2009,9(1):182-12
Background
Ecological specialization is pervasive in phytophagous arthropods. In such specialization mode, limits to host range are imposed by trade-offs preventing adaptation to several hosts. The occurrence of such trade-offs is inferred by a pattern of local adaptation, i.e., a negative correlation between relative performance on different hosts. 相似文献11.
Seo Young Kim Min Jung Kim Suzanne M Cadarette Daniel H Solomon 《Arthritis research & therapy》2010,12(1):R30
Introduction
Bisphosphonates are the most commonly used drugs for the prevention and treatment of osteoporosis. Although a recent FDA review of the results of clinical trials reported no clear link between bisphosphonates and serious or non-serious atrial fibrillation (AF), some epidemiologic studies have suggested an association between AF and bisphosphonates. 相似文献12.
Richard P Auburn Roslin R Russell Bettina Fischer Lisa A Meadows Santiago Sevillano Matilla Steven Russell 《BMC bioinformatics》2006,7(1):102-9
Background
Microarrays were first developed to assess gene expression but are now also used to map protein-binding sites and to assess allelic variation between individuals. Regardless of the intended application, efficient production and appropriate array design are key determinants of experimental success. Inefficient production can make larger-scale studies prohibitively expensive, whereas poor array design makes normalisation and data analysis problematic. 相似文献13.
Oliver P Stannus Graeme Jones Stephen J Quinn Flavia M Cicuttini Dawn Dore Changhai Ding 《Arthritis research & therapy》2010,12(3):R95
Introduction
The associations between leptin, interleukin (IL)-6, and hip radiographic osteoarthritis (OA) have not been reported, and their roles in obesity-related hip OA are unclear. The aim of this study was to describe the associations between leptin, IL-6, and hip radiographic osteoarthritis (ROA) in older adults. 相似文献14.
Background
Proteins are assumed to contain all the information necessary for unambiguous folding (Anfinsen's principle). However, ab initio structure prediction is often not successful because the amino acid sequence itself is not sufficient to guide between endless folding possibilities. It seems to be a logical to try to find the "missing" information in nucleic acids, in the redundant codon base. 相似文献15.
16.
Background
Ethnic differences have been reported with regard to several medical therapies. The aim of this study was to investigate the relation between ethnicity and thrombolysis in stroke patients. 相似文献17.
Carmine Gazzaruso Adriana Garzaniti Stefano Giordanetti Colomba Falcone Pietro Fratino 《Cardiovascular diabetology》2002,1(1):5-9
Background
There is little data on the relationship between novel cardiovascular risk factors and silent coronary artery disease (CAD) in diabetic patients. We investigated whether Lipoprotein(a), homocysteine and apolipoprotein(a) polymorphism are associated with angiographically assessed asymptomatic coronary artery disease (CAD) in diabetic patients. 相似文献18.
Background
Experimental results are commonly fitted by determining parameter values of suitable mathematical expressions. In case a relation exists between different data sets, the accuracy of the parameters obtained can be increased by incorporating this relationship in the fitting process instead of fitting the recordings separately. 相似文献19.
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