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Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas 总被引:4,自引:0,他引:4
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Fujitani Y Kajimoto Y Yasuda T Matsuoka TA Kaneto H Umayahara Y Fujita N Watada H Miyazaki JI Yamasaki Y Hori M 《Molecular and cellular biology》1999,19(12):8281-8291
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PAX6, paired domain influences sequence recognition by the homeodomain 总被引:10,自引:0,他引:10
Mishra R Gorlov IP Chao LY Singh S Saunders GF 《The Journal of biological chemistry》2002,277(51):49488-49494
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Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4 总被引:3,自引:0,他引:3
Smith SB Gasa R Watada H Wang J Griffen SC German MS 《The Journal of biological chemistry》2003,278(40):38254-38259
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Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages 总被引:27,自引:0,他引:27
Herrera PL 《Development (Cambridge, England)》2000,127(11):2317-2322
To analyze cell lineage in the pancreatic islets, we have irreversibly tagged all the progeny of cells through the activity of Cre recombinase. Adult glucagon alpha and insulin beta cells are shown to derive from cells that have never transcribed insulin or glucagon, respectively. Also, the beta-cell progenitors, but not alpha-cell progenitors, transcribe the pancreatic polypeptide (PP) gene. Finally, the homeodomain gene PDX1, which is expressed by adult beta-cells, is also expressed by alpha-cell progenitors. Thus the islet alpha- and beta-cell lineages appear to arise independently during ontogeny, probably from a common precursor. 相似文献