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The same nuclear proteins bind the proximal CACCC box of the human beta-globin promoter and a similar sequence in the enhancer 总被引:3,自引:0,他引:3
B Giglioni P Comi A Ronchi R Mantovani S Ottolenghi 《Biochemical and biophysical research communications》1989,164(1):149-155
Using in vitro assays, we show that nuclear proteins related to the Sp1 and GT-1 factors bind to a CACCC box sequence in the human beta-globin enhancer, adjacent to binding sites for the erythroid-specific factor NFE1 and the ubiquitous factor CP1. The same proteins are known to bind to the proximal, but not to the distal, CACCC, box in the human beta-globin promoter. A C G mutation in the promoter CACCC box, known to cause beta-thalassemia, greatly decreases protein binding to the CACCC box; the same effect is obtained when this mutation is introduced into the enhancer CACCC box. 相似文献
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T W Beck U Brennscheidt G Sithanandam J Cleveland U R Rapp 《Molecular and cellular biology》1990,10(7):3325-3333