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The rules that govern scientific naming in botany (including phycology and mycology) are revised at Nomenclature Section meetings at successive International Botanical Congresses. The most recent edition of the International Code of Botanical Nomenclature (Vienna Code) embodies the decisions of the XVII International Botanical Congress held in Vienna in 2005 and supersedes the Saint Louis Code. This paper presents an account of the main differences between the two Codes, including those related with starting points, effective publication, valid publication, fossil plants, pleomorphic fungi, orthography, and the Appendices. 相似文献
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In the RNA world, RNA is assumed to be the dominant macromolecule performing most, if not all, core "house-keeping" functions. The ribo-cell hypothesis suggests that the genetic code and the translation machinery may both be born of the RNA world, and the introduction of DNA to ribo-cells may take over the informational role of RNA gradually, such as a mature set of genetic code and mechanism enabling stable inheritance of sequence and its variation. In this context, we modeled the genetic code in two content variables-GC and purine contents-of protein-coding sequences and measured the purine content sensitivities for each codon when the sensitivity (% usage) is plotted as a function of GC content variation. The analysis leads to a new pattern-the symmetric pattern-where the sensitivity of purine content variation shows diagonally symmetry in the codon table more significantly in the two GC content invariable quarters in addition to the two existing patterns where the table is divided into either four GC content sensitivity quarters or two amino acid diversity halves. The most insensitive codon sets are GUN (valine) and CAN (CAR for asparagine and CAY for aspartic acid) and the most biased amino acid is valine (always over-estimated) followed by alanine (always under-estimated). The unique position of valine and its codons suggests its key roles in the final recruitment of the complete codon set of the canonical table. The distinct choice may only be attributable to sequence signatures or signals of splice sites for spliceosomal introns shared by all extant eukaryotes. 相似文献
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The causes and consequences of the nonrandom structure of the standard genetic code (SGC) have been of long-standing interest. A recent study reported that mutations in present-day protein-coding sequences are less likely to increase proteomic nitrogen and carbon uses under the SGC than under random genetic codes, concluding that the SGC has been selectively optimized for resource conservation. If true, this finding might offer important information on the environment in which the SGC and some of the earliest life forms evolved. However, we here show that the hypothesis of optimization of a genetic code for resource conservation is theoretically untenable. We discover that the aforementioned study estimated the expected mutational effect by inappropriately excluding mutations lowering resource consumptions and including mutations involving stop codons. After remedying these problems, we find no evidence that the SGC is optimized for nitrogen or carbon conservation. 相似文献
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D. Berleant M. White E. Pierce E. Tudoreanu A. Boeszoermenyi Y. Shtridelman J. C. Macosko 《Cell biochemistry and biophysics》2009,55(2):107-116
The standard codon table is a primary tool for basic understanding of molecular biology. In the minds of many, the table’s
orderly arrangement of bases and amino acids is synonymous with the true genetic code, i.e., the biological coding principle
itself. However, developments in the field reveal a much more complex and interesting picture. In this article, we review
the traditional codon table and its limitations in light of the true complexity of the genetic code. We suggest the codon
table be brought up to date and, as a step, we present a novel superposition of the BLOSUM62 matrix and an allowed point mutation
matrix. This superposition depicts an important aspect of the true genetic code—its ability to tolerate mutations and mistranslations. 相似文献
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By combining crystallographic and NMR structural data for RNA-bound amino acids within riboswitches, aptamers, and RNPs, chemical
principles governing specific RNA interaction with amino acids can be deduced. Such principles, which we summarize in a “polar
profile”, are useful in explaining newly selected specific RNA binding sites for free amino acids bearing varied side chains
charged, neutral polar, aliphatic, and aromatic. Such amino acid sites can be queried for parallels to the genetic code. Using
recent sequences for 337 independent binding sites directed to 8 amino acids and containing 18,551 nucleotides in all, we
show a highly robust connection between amino acids and cognate coding triplets within their RNA binding sites. The apparent
probability (P) that cognate triplets around these sites are unrelated to binding sites is ≅5.3 × 10−45 for codons overall, and P ≅ 2.1 × 10−46 for cognate anticodons. Therefore, some triplets are unequivocally localized near their present amino acids. Accordingly,
there was likely a stereochemical era during evolution of the genetic code, relying on chemical interactions between amino
acids and the tertiary structures of RNA binding sites. Use of cognate coding triplets in RNA binding sites is nevertheless
sparse, with only 21% of possible triplets appearing. Reasoning from such broad recurrent trends in our results, a majority
(approximately 75%) of modern amino acids entered the code in this stereochemical era; nevertheless, a minority (approximately
21%) of modern codons and anticodons were assigned via RNA binding sites. A Direct RNA Template scheme embodying a credible
early history for coded peptide synthesis is readily constructed based on these observations. 相似文献
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The use of structured knowledge representations-ontologies and terminologies-has become standard in biomedicine. Definitions of ontologies vary widely, as do the values and philosophies that underlie them. In seeking to make these views explicit, we conducted and summarized interviews with a dozen leading ontologists. Their views clustered into three broad perspectives that we summarize as mathematics, computer code, and Esperanto. Ontology as mathematics puts the ultimate premium on rigor and logic, symmetry and consistency of representation across scientific subfields, and the inclusion of only established, non-contradictory knowledge. Ontology as computer code focuses on utility and cultivates diversity, fitting ontologies to their purpose. Like computer languages C++, Prolog, and HTML, the code perspective holds that diverse applications warrant custom designed ontologies. Ontology as Esperanto focuses on facilitating cross-disciplinary communication, knowledge cross-referencing, and computation across datasets from diverse communities. We show how these views align with classical divides in science and suggest how a synthesis of their concerns could strengthen the next generation of biomedical ontologies. 相似文献
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Circadian rhythms in physiology and behavior are ultimately regulated at the hypothalamic level by the suprachiasmatic nuclei
(SCN). This central oscillator transduces photic information to the cellular clocks in the periphery through the autonomic
nervous system and the neuroendocrine system. The fact that these two systems have been shown to modulate leukocyte physiology
supports the concept that the circadian component is an important aspect of hypothalamic-immune communication. Circadian disruption
has been linked to immune dysregulation, and recent reports suggest that several circadian clock genes, in addition to their
time-keeping role, are involved in the immune response. In this overview, we summarize the findings demonstrating that Natural
Killer (NK) cell function is under circadian control.
Special issue article in honor of George Fink. 相似文献
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Thomas A. Gonda Jack D. Barchas Donald N. Mac Intosh 《The Western journal of medicine》1966,104(4):272-277
A physician has an ethical duty to hold in confidence communications made to him by his patient. A legal recognition of this ethical duty is found in the concept of privilege, which is the subject of this article. January 1967 will bring to California physicians a new protection for patients'' communications. The physician-patient privilege has been redefined to include confidential communications made during diagnostic evaluation, those made to non-licensed physicians, interns and medical aides, and those overheard by eavesdroppers. There has been added a psychotherapist-patient privilege designed to facilitate communications required in psychotherapy as well as in behavioral research.This paper first presents a brief historical background and discusses the protections and limitations afforded by the new California Evidence Code. There follows a section on the psychotherapist-patient privilege with the recommendation that in the context of psychotherapy, patients of physicians who are not psychiatrists should be afforded the additional benefits of the psychotherapist-patient privilege. Lastly, advice is given concerning the physician''s conduct in relation to his duty to claim privilege under the new code. 相似文献
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The place theory proposed by Jeffress (1948) is still the dominant model of how the brain represents the movement of sensory stimuli between sensory receptors. According to the place theory, delays in signalling between neurons, dependent on the distances between them, compensate for time differences in the stimulation of sensory receptors. Hence the location of neurons, activated by the coincident arrival of multiple signals, reports the stimulus movement velocity. Despite its generality, most evidence for the place theory has been provided by studies of the auditory system of auditory specialists like the barn owl, but in the study of mammalian auditory systems the evidence is inconclusive. We ask to what extent the somatosensory systems of tactile specialists like rats and mice use distance dependent delays between neurons to compute the motion of tactile stimuli between the facial whiskers (or 'vibrissae'). We present a model in which synaptic inputs evoked by whisker deflections arrive at neurons in layer 2/3 (L2/3) somatosensory 'barrel' cortex at different times. The timing of synaptic inputs to each neuron depends on its location relative to sources of input in layer 4 (L4) that represent stimulation of each whisker. Constrained by the geometry and timing of projections from L4 to L2/3, the model can account for a range of experimentally measured responses to two-whisker stimuli. Consistent with that data, responses of model neurons located between the barrels to paired stimulation of two whiskers are greater than the sum of the responses to either whisker input alone. The model predicts that for neurons located closer to either barrel these supralinear responses are tuned for longer inter-whisker stimulation intervals, yielding a topographic map for the inter-whisker deflection interval across the surface of L2/3. This map constitutes a neural place code for the relative timing of sensory stimuli. 相似文献
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Di Giulio M 《Journal of molecular evolution》2002,55(5):616-622
A logical-evolutionary analysis is conducted to clarify whether or not pathways of type Glu-tRNAGln \rightarrow Gln-tRNAGln
are molecular fossils of the mechanism that gave rise to the evolutionary organization of the genetic code. The result of
this analysis is that these pathways are most likely a manifestation of this mechanism. This provides strong evidence in favor
of the coevolution theory of genetic code origin, as this theory is based on the amino acid biosynthetic transformation taking
place on tRNA-like molecules which imprinted the genetic code structuring. Comments on the different interpretations of these
pathways found in the literature are also provided. 相似文献
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The genetic code relates nucleotide sequence to amino acid sequence and is shared across all organisms, with the rare exceptions of lineages in which one or a few codons have acquired novel assignments. Recoding of UGA from stop to tryptophan has evolved independently in certain reduced bacterial genomes, including those of the mycoplasmas and some mitochondria. Small genomes typically exhibit low guanine plus cytosine (GC) content, and this bias in base composition has been proposed to drive UGA Stop to Tryptophan (Stop→Trp) recoding. Using a combination of genome sequencing and high-throughput proteomics, we show that an α-Proteobacterial symbiont of cicadas has the unprecedented combination of an extremely small genome (144 kb), a GC–biased base composition (58.4%), and a coding reassignment of UGA Stop→Trp. Although it is not clear why this tiny genome lacks the low GC content typical of other small bacterial genomes, these observations support a role of genome reduction rather than base composition as a driver of codon reassignment. 相似文献