Tournaments of Value: Sociability and Hierarchy in a Yemeni Town

Tournaments of Value: Sociability and Hierarchy in. Yemeni Town. Anne Meneley. Toronto: University of Toronto Press, 1996. 216 pp.     

The Self as Social Artifice: Some Consequences of Stanislavski

Practice commonly develops independent of theory: only rarely does some heritable informational structure knowingly emerge. With this in mind, Biosemiotic theory is well served by an informed synthesis with Constantin Stanislavski’s theatrical technique. For it is not enough merely to catalog signage by studying the consequence of its function, we also seek to generate signs with knowing intent. This implies more than the strategic use of signs, which all complex living things do, and of which our many subjective selves emerge. It calls for an objective artifice of signs, that is, some set of techniques competent to produce subjectivity, and capable of being objectified such that it can become a knowable standard. This is precisely what Stanislavski offers, ways of knowingly creating novel, actual, believably generative, signs. Within the realm of human action and in terms of human knowing, he positively exemplifies applied semiotic theory: his approach to dramatizing fictional characters also expresses how self-consciousness comes to be. What Stanislavski implies, Charles Tilly presumes and this essay asserts: our own biotic evolution has been influenced by post-biotic or metaphoric evolution, which results from the ‘living’ interaction of certain classes of non-living things. These derive from the pragmatic a priori made implicit by Chauncey Wright, which is the motivation of living things to act on specific needs within specific situations. The need to breathe is one example; the need to make competent use of existing epistemic structures is another. But such structures have their own needs, and ‘act’ to fill them. When this is compounded culturally, it may result in self-consciousness – a self-constructed artifice of semiosis with great consequence to biotic processes. Tilly supplies evidence that such compounding happens within human society, as well as a theoretical basis for its expression as a semiotic sociology. This essay uses pragmatic semiotics to explore the strong parallels that exist between the deliberately objective motivations upon which science, sanity and self-consciousness all depend, Stanislavski’s practicable artifice of signaling pathways and social emergence, and Tilly’s approach to society as ongoing performance.     

The Prognostic Value of Global DNA Hypomethylation in Cancer: A Meta-Analysis

Background

Aberrant methylation of the global genome has been investigated as a prognostic indicator in various cancers, but the results are controversial and ambiguous.

Methods and Findings

This meta-analysis presents pooled estimates of the evidence to elucidate this issue. We searched the electronic databases: PubMed, Embase, ISI Web of Science and the Cochrane library (up to August 2013) to identify all of the relevant studies. The association between the level of surrogates'' indexes of genome-wide hypomethylation (LINE-1, Alu and Sat–α) and the overall survival (OS) of cancer patients was examined. In addition, the pooled hazard ratios (HRs) with their 95% confidence interval (95%CI) were calculated to estimate the influences through fixed-effects and random-effects model. Finally, twenty studies with total population of 5447 met the inclusion criteria. The results indicate that the summary HRs for the studies employing LINE-1, Alu, and Sat-α repetitive elements also show that the global DNA hypomethylation have significant desirable effects on the tumour prognostic value. The pooled HRs (and CIs) of LINE-1, Alu and Sat-α were 1.83 (1.38–2.44), 2.00 (1.16–3.45), and 2.92 (1.04–8.25), with a heterogeneity measure index of I² (and p-value) shows of 66.6% (p = 0.001), 57.1% (p = 0.053) and 68.2% (p = 0.076) respectively. The meta-regression and subgroup analysis indicated that the percentage of hypomethylated sample of cancer patients is one source of heterogeneity.

Conclusion

Our meta-analysis findings support the hypothesis that the global DNA hypomethylation is associated with a detrimental prognosis in tumour patients.     

Hierarchy in the Forest: The Evolution of Egalitarian Behavior

Hierarchy in the Forest: The Evolution of Egalitarian Behavior. Christopher Boehm. Cambridge, MA: Harvard University Press, 1999.292 pp.     

The Value of Body Weight Measurement to Assess Dehydration in Children

Dehydration secondary to gastroenteritis is one of the most common reasons for office visits and hospital admissions. The indicator most commonly used to estimate dehydration status is acute weight loss. Post-illness weight gain is considered as the gold-standard to determine the true level of dehydration and is widely used to estimate weight loss in research. To determine the value of post-illness weight gain as a gold standard for acute dehydration, we conducted a prospective cohort study in which 293 children, aged 1 month to 2 years, with acute diarrhea were followed for 7 days during a 3-year period. The main outcome measures were an accurate pre-illness weight (if available within 8 days before the diarrhea), post-illness weight, and theoretical weight (predicted from the child’s individual growth chart). Post-illness weight was measured for 231 (79%) and both theoretical and post-illness weights were obtained for 111 (39%). Only 62 (21%) had an accurate pre-illness weight. The correlation between post-illness and theoretical weight was excellent (0.978), but bootstrapped linear regression analysis showed that post-illness weight underestimated theoretical weight by 0.48 kg (95% CI: 0.06–0.79, p<0.02). The mean difference in the fluid deficit calculated was 4.0% of body weight (95% CI: 3.2–4.7, p<0.0001). Theoretical weight overestimated accurate pre-illness weight by 0.21 kg (95% CI: 0.08–0.34, p = 0.002). Post-illness weight underestimated pre-illness weight by 0.19 kg (95% CI: 0.03–0.36, p = 0.02). The prevalence of 5% dehydration according to post-illness weight (21%) was significantly lower than the prevalence estimated by either theoretical weight (60%) or clinical assessment (66%, p<0.0001).These data suggest that post-illness weight is of little value as a gold standard to determine the true level of dehydration. The performance of dehydration signs or scales determined by using post-illness weight as a gold standard has to be reconsidered.     

The Evolution of the Linnaean Hierarchy

The Linnaean system of classification is a threefold system of theoretical assumptions, sorting rules, and rules of nomenclature. Over time, that system has lost its theoretical assumptions as well as its sorting rules. Cladistic revisions have left it less and less Linnaean. And what remains of the system is flawed on pragmatic grounds. Taking all of this into account, it is time to consider alternative systems of classification.     

Moments of Hierarchy: Constructing Social Stratification by Means of Language, Food, Space, and the Body in Pohnpei, Micronesia

In this paper I examine relationships between multiple semiotic modes used to construct hierarchy, and I show the importance of going beyond our traditional notion of language to look at how social actors employ a range of semiotic resources in organizing and interpreting social relations. Using examples from Pohnpei, Micronesia, I show how notions of superior and inferior are compounded through several sign systems—spatial relations, food sharing, the body, and language. These systems act oppositionally as well as cooperatively to produce situated ideas of social inequality, ideas built out of disequilibrium of bodies in space, of referents in language, and distribution of resources, as well as contradictions in the interactions of these signs. The compounding of signs not only recruits multiple sensory modes and perspectives in the exposition of hierarchical relations, but entails a notion of the contradictory nature of status relations. Using examples from a Pohnpeian feast, I explore the creative interplay of sign systems in the construction of "moments" of hierarchy in a large, public setting and discuss how through the practice of title-giving, which virtually every adult member of the society participates in, a particular idea of social inequality, built out of multiple sign systems, is mapped onto each body, [language, interaction, politics, Oceania, social stratification, hierarchy]     

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

The strongest BMI–associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alterations in body composition. Thus understanding how and where Fto regulates food intake, energy expenditure, and body composition is a challenge. To address this we generated a series of mice with distinct temporal and spatial loss of Fto expression. Global germline loss of Fto resulted in high perinatal lethality and a reduction in body length, fat mass, and lean mass. When ratio corrected for lean mass, mice had a significant increase in energy expenditure, but more appropriate multiple linear regression normalisation showed no difference in energy expenditure. Global deletion of Fto after the in utero and perinatal period, at 6 weeks of age, removed the high lethality of germline loss. However, there was a reduction in weight by 9 weeks, primarily as loss of lean mass. Over the subsequent 10 weeks, weight converged, driven by an increase in fat mass. There was a switch to a lower RER with no overall change in food intake or energy expenditure. To test if the phenotype can be explained by loss of Fto in the mediobasal hypothalamus, we sterotactically injected adeno-associated viral vectors encoding Cre recombinase to cause regional deletion. We observed a small reduction in food intake and weight gain with no effect on energy expenditure or body composition. Thus, although hypothalamic Fto can impact feeding, the effect of loss of Fto on body composition is brought about by its actions at sites elsewhere. Our data suggest that Fto may have a critical role in the control of lean mass, independent of its effect on food intake.     

Presence in the Flesh: The Body in Medicine

Presence in the Flesh: The Body in Medicine. Katharine Young. Cambridge, MA: Harvard University Press, 1997.200 pp.     

The Global Flow of Hard Disk Drives: Quantifying the Concept of Value Leakage in E‐waste Recovery Systems

The remaining value within end‐of‐use/life hard disk drives (EoU/L HDDs) is often not optimally recovered. The improper collection and recovery of HDDs contribute not only to rising environmental and social concerns worldwide, but also to the transformation of the economy and a significant loss of value. Currently, the most preferred treatment option for used hard drives is to recover the metals with the highest recycling effectiveness, such as steel and aluminum, via a shredding‐based recycling process that results in both value and material leakages. The complexity of retrieving the remaining values within EoU/L HDDs demands a larger view of the global supply of HDDs available for recovery. The aim of this paper is to first identify the geographical patterns of transboundary global shipments of new and used HDDs between developing and developed regions, and then capture and quantify the value leakage by bringing several unique perspectives. Two analyses have been conducted. First, the loss of value due to the insufficient recovery of neodymium (Nd) at the global level is quantified. Second, the value leakage as a result of the delay on on‐time reuse of HDDs is captured. Furthermore, the central challenges toward proper recovery of HDDs, where consumer electronic industry can make significant contributions, have been identified. HDDs are well positioned to contribute important insights to the recovery of other electronic devices, so the findings from HDDs can be adopted for other types of electronics.     

The Woman in the Surgeon's Body: Understanding Difference

Praxis is not simply about learning cultural rules by rote, it is about coming to an understanding of social distinctions through your body.
Much of clinical and practical knowledge [in medicine] is embodied knowledge-knowledge sensed through and with the body. This includes senses of sight, sound, touch, smell.     

Informative Value of Temperatures in Different Areas of the Human Body for Correcting Body Thermal Imbalance during Extravehicular Activities

Identification of noninvasive and informative sites on the body reflecting the development of body thermal imbalance during extravehicular activities (EVAs) is highly important for enhancing astronaut safety. Temperature changes were evaluated on several areas of the head (the mastoid fossa (T _mf ), the forehead (T _fo ), and the cheek (T _ch )) and on the fingers (T _fing ). Subjects were dressed in a multicompartment liquid cooling/warming garment. Studies I and II consisted of different combinations of hood versus garment cooling or warming imposed across stages; studies III and IV involved sagittally divided cooling or warming regimes with the hood worn (study III) or with the head uncovered (study IV). In studies I and II, T _mf significantly (P < 0.05) differed between stages 2, when the head was cooled and the rest of the body heated, and 3, when the head was heated and the rest of the body cooled. The T _mf changes were consistent with the thermal conditions imposed on the head but not reflective of the developing body heat deficit. In study III, the T _mf at stages 2 and 3 on the right or the left followed the thermal conditions on the ipsilateral side of the body (P < 0.01). In study IV, T _fing showed no significant differences across stages. In studies I–IV, T _fing showed consistent changes across stages (P < 0.05), reflecting the developing body heat deficit. In all studies, there were no significant differences in rectal temperature (T _re ) across stages. T _mf and temperatures at other head skin sites did not respond in accordance with the actual intensity of a heat or cold flux from the garment and were not reflective of the overall development of body thermal imbalance. T _fing was a more adequate indicator of initial thermal destabilization and provided information that would be useful for monitoring the thermal balance and comfort during EVAs.     

The Evolutionary Origins of Hierarchy

Hierarchical organization—the recursive composition of sub-modules—is ubiquitous in biological networks, including neural, metabolic, ecological, and genetic regulatory networks, and in human-made systems, such as large organizations and the Internet. To date, most research on hierarchy in networks has been limited to quantifying this property. However, an open, important question in evolutionary biology is why hierarchical organization evolves in the first place. It has recently been shown that modularity evolves because of the presence of a cost for network connections. Here we investigate whether such connection costs also tend to cause a hierarchical organization of such modules. In computational simulations, we find that networks without a connection cost do not evolve to be hierarchical, even when the task has a hierarchical structure. However, with a connection cost, networks evolve to be both modular and hierarchical, and these networks exhibit higher overall performance and evolvability (i.e. faster adaptation to new environments). Additional analyses confirm that hierarchy independently improves adaptability after controlling for modularity. Overall, our results suggest that the same force–the cost of connections–promotes the evolution of both hierarchy and modularity, and that these properties are important drivers of network performance and adaptability. In addition to shedding light on the emergence of hierarchy across the many domains in which it appears, these findings will also accelerate future research into evolving more complex, intelligent computational brains in the fields of artificial intelligence and robotics.