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1.
Reflection of Anxiety in the Characteristics of Evoked EEG Potentials in 10- to 11-Year-Old Children
We studied the peculiarities of the amplitude/time parameters of evoked EEG potentials (EPs) and event-related potentials
(ERPs) in 10- to 11-year-old children characterized by low and high anxiety levels. The latter levels were estimated using
the scale of the manifest anxiety test of Prikhozhan and projective techniques (“House–Tree–Person,” HTP, and the Lüscher
color test). For children with a high anxiety level, the amplitudes of the following EP components and ERPs were lower than
those in low-anxiety children of the same age: P1 (predominantly in the occipital region of the left hemisphere), P2 (in the
right occipital region), and Р300 wave (in different loci of both hemispheres). In high-anxiety children, we also more frequently
observed increased amplitudes of the N2 component in the left parietal and right occipital regions. High-anxiety individuals
were characterized by longer latencies of component P1 (mostly in the right frontal and left central regions) and, at the
same time, shorter latencies of component N1 (in the parietal and occipital regions of the left hemisphere and also in the
right temporal region). Thus, we found that the amplitude/time characteristics of a few EP components and ERPs in children
with high anxiety levels differ statistically significantly from the parameters of corresponding EPs/ERPs in individuals of
the same age but with low anxiety levels. 相似文献
2.
We studied correlations of the spectral characteristics of EEG with the indices characterizing the level of attention in 60
children (12 to 13 years old). Indices of voluntary attention were measured using a complex of psychological tests, including
a Bourdon’s test (correcture test), a two-stimulus go/no-go test, a computer test (a modification of the Bourdon’s test for
characterization of concentration and stability of attention), and Schulte’s tables. Children manifesting a good working ability
(corresponding to the results of the go/no-go test and correcture test) showed relatively high values of the ratio of spectral
powers (SPs) of the beta 1 and theta rhythms. These ratios were greater in the right hemisphere; this is probably indicative
of a greater contribution of neuronal mechanisms of this hemisphere to providing watchfulness and stability of attention.
Children demonstrating increased impulsivity (according to the results of the go/no-go test) were characterized by low modal
frequencies of the alpha rhythm in the occipital brain regions, while children with relatively high values of this frequency
in various cerebral regions demonstrated high indices of attentiveness and rates of the cognitive processes. Children performing
the test task with especially high accuracy were characterized by high ratios of SPs of the low-frequency beta rhythm vs theta rhythm (mostly in the central and parietal regions of both hemispheres). The approach we have applied can be used for
measuring the objective indices characterizing the state of the attention sphere in children.
Neirofiziologiya/Neurophysiology, Vol. 38, No. 3, pp. 248–256, May–June, 2006. 相似文献
3.
A. G. Snegir 《Neurophysiology》1999,31(1):18-22
We compared the parameters of acoustic event-related evoked potentials (ERP; tone stimulation) in healthy young and healthy
aged persons with those in patients suffering from Alzheimer’s disease (groups 1–3, respectively). It was found that the mean
peak latencies (PL) of the components P1-N2 in group 1 were longer than those in group 2, and the absolute values of the amplitudes
of these components were more negative. In Alzheimer patients (group 3), the PL of the components P1–P2 were much longer than
those in group 2, and their peak-to-peak amplitudes dropped. The latencies of a simple sensorimotor reaction in groups 1–3
progressively increased (about three times). The ERP observed in two modes (“blackground” and “attention,” the latter with
the performance of the sensorimotor reaction) were subjected to spectral analysis. Possible reasons for and mechanisms of
those modifications of evoked potentials, which relate to physiological and pathological aging of the brain, are discussed. 相似文献
4.
We studied correlations between the estimates of the neuroticism level (one of the most significant factors of the emotional
sphere of a personality) and the amplitude/time characteristics of evoked EEG potentials (EPs). Passive and negative emotiogenic,
as well as neutral (from the emotional aspect) visual images (stimuli from the set of the International Affective Picture
System, IAPS), were presented to 102 tested persons. The neuroticism level was estimated based on Eysenck’s personality questionnaire.
We found that subjects with high estimates of the neuroticism level are characterized, in general, by somewhat higher rates
and intensities of processing of emotionally negative information, a higher level of activation of the processes of automatic
attention, and readiness to react to both significant and insignificant visual signals (with the aim of probably fighting
of a threat). These peculiarities were manifested as relatively shorter latencies of the Р1, N1, Р2, N2, and Р3 components
and as higher amplitudes of the Р2 component in the EPs induced by emotionally negative stimuli, as compared with the corresponding
indices in subjects with a low neuroticism level. The amplitudes of the N2 component in the case of presentation of negative
and neutral stimuli showed a trend toward a decrease. The approach used can be applied for obtaining objective indices interpreted
as correlates of peculiarities of the emotional responsiveness typical of a personality. 相似文献
5.
I. N. Konareva 《Neurophysiology》2007,39(2):137-146
In a group of 76 adults of both sexes, we examined interrelations between the level of aggressiveness of the individual (diagnosed
using the Buss-Durkee Hostility Inventory) and parameters of event-related EEG potentials (ERPs) recorded under conditions
of two behavioral test acts including a motor component. Within the framework of task A, the subject must push a button with
the shortest delay after an executory signal preceded by a warning signal; the time of sensorimotor reaction was measured.
Under these conditions, we recorded the contingent negative variayion (CNV) and the P300 potential. In the case of task B,
it was necessary to measure a definite time interval limited by two pushings of the button. Under these conditions, the readiness
potential (RP) was recorded in addition to the CNV and P300. The C3 and C4 leads were used (according to the 10–20 system);
the time constant of an amplification tract was 10 sec. Despite natural broad interindividual variability, high amplitudes
of the recorded ERPs (RP, CNV, and P300) in general corresponded to lower indices by scales of the Buss-Durkee inventory and
smaller values of the indices of aggressiveness and hostility. These interrelations are, probably, based on the fact that
both characteristics of aggressiveness of the personality and EEG amplitude parameters are to a considerable extent determined
by hereditary factors. It is believed that the respective peculiarities of the neurodynamic constitution of the individual
are to a great extent dependent on the specificities of organization and functioning of a few neurotransmitter (in particular,
aminergic) and neurohumoral systems.
Neirofiziologiya/Neurophysiology, Vol. 39, No. 2, pp. 154–164, March–April, 2007. 相似文献
6.
We recorded visual evoked potentials (VEPs) in children suffering from medium and high myopia (3.0 to 6.0 and more than 6.0
D; 28 and 21 patients, respectively); a light flash was used as the stimulus. The VEPs were recorded before and after a curative
course of phosphene electrostimulation (PhES; frequency 15 sec−1, 10 to 15 10-min-long everyday sessions). The above course resulted in clear trends toward decreases in the peak latencies
of the P60 and P100 VEP components; changes in the latencies of other components were expressed to a lesser extent. In children
with medium myopia, the latency of the P60 component decreased, on average, by more than 21% (P < 0.05); in patients with high myopia, the respective decrease was about 12% (P > 0.05). These shifts were accompanied by increases in the mean amplitudes of the P60 and, to a lesser degree, P100 (more
expressed in medium myopia). The data obtained allow us to suppose that the PhES course provides increases in the transmission
velocity through relay structures of the visual analyzer and in neuronal networks of the visual cortex and also in the number
of neuronal units whose activity is reflected in generation of VEPs. Application of the PhES technique is much more effective
in relatively moderate myopia.
Neirofiziologiya/Neurophysiology, Vol. 40, No. 3, pp. 228–235, May–June, 2008. 相似文献
7.
Two functional magnetic resonance imaging (fMRI) experiments were undertaken to measure the effect of neurofeedback training (NFT), in AD/HD children, on the neural substrates of selective attention and response inhibition. Twenty unmedicated AD/HD children participated to these experiments. Fifteen children were randomly assigned to the Experimental (EXP) group whereas the other five children were randomly assigned to the Control (CON) group. Only subjects in the EXP group underwent NFT. EXP subjects were trained to enhance the amplitude of the SMR (12–15 Hz) and beta 1 activity (15–18 Hz), and decrease the amplitude of theta activity (4–7 Hz). Subjects from both groups were scanned one week before the beginning of NFT (Time 1) and 1 week after the end of NFT (Time 2), while they performed a “Counting Stroop” task (Experiment 1) and a Go/No-Go task (Experiment 2). At Time 1, in both groups, the Counting Stroop task was associated with significant activation in the left superior parietal lobule. For the Go/No-Go task, no significant activity was detected in the EXP and CON groups. At Time 2, in both groups, the Counting Stroop task was associated with significant activation of the left superior parietal lobule. This time, however, there were significant loci of activation, in the EXP group, in the right ACC, left caudate nucleus, and left substantia nigra. No such activation loci were seen in CON subjects. For the Go/No-Go task, significant loci of activation were noted, in the EXP group, in the right ventrolateral prefrontal cortex, right ACcd, left thalamus, left caudate nucleus, and left substantia nigra. No significant activation of these brain regions was measured in CON subjects. These results suggest that NFT has the capacity to functionally normalize the brain systems mediating selective attention and response inhibition in AD/HD children. 相似文献
8.
We estimated the efficacy of using the technique of feedback (FB) by EEG characteristics (EEG-FB, neurotherapy) with the aim
of reducing increased anxiety levels in healthy 10- to 14-year-old children. The anxiety level was estimated using the Prikhojan
anxiety test, the Spielberger–Khanin questionnaire, and the House–Tree–Person projective drawing technique. Positive effects
of series of neurotherapy sessions were obvious. After training was completed, we observed significant increases in the ratios
of the amplitudes of alpha and theta rhythms, semsorimotor and theta rhythms, as well as of the modal frequency of the EEG
alpha rhythm in tested persons of the experimental group (n = 7). In the control group (n = 10), changes in these values did not reach the significance level. In the experimental group of tested persons subjected
to EEG-FB sessions, the anxiety level decreased appreciably; in addition, the indices “feeling of inferiority” and “frustration”
decreased significantly. In the control group, alterations of these psychological indices were not unidirectional. Therefore,
modifications of the EEG pattern, which occurred in the course of training and were accompanied by a decrease in the anxiety
level in the experimental group, can be indicative of the expediency of EEG-FB for the reduction of high anxiety levels in
children and teenagers. 相似文献
9.
We studied changes in the power spectra of EEG in the course of sessions of feedback by EEG characteristics (neurofeedback
sessions) and estimated the effects of neurofeedback on psychological and EEG correlates of voluntary attention. Indices of
the latter were estimated using Bourdon’s test (a correcture test) and Schulte’s tables. Twenty-nine reasonably healthy 10-to
13-year-old children took part in the study; they were divided into two groups, an experimental group (n = 12) and a control group (n = 15). The results obtained support the statement on noticeable changes in the functional state of the brain both immediately
in the course of a neurofeedback session and after a course of such trainings. Changes in the ratios of the spectral powers
of the beta1
vs theta rhythms and the low-frequency beta vs theta rhythms were found in EEG recorded from the sensorimotor zone of the right hemisphere (C4). The observed changes in
the spectral characteristics of EEG induced by the course of neurofeedback sessions were accompanied by the improvement of
a few indices of voluntary attention.
Neirofiziologiya/Neurophysiology, Vol. 38, Nos. 5/6, pp. 458–465, September–December, 2006. 相似文献
10.
I. N. Konareva 《Neurophysiology》2011,42(5):354-361
In a group of 70 adults of both sexes, we examined interrelations between the estimates of expression of a coronary-prone
type (type A) of the personality (measured using the Jenkins questionnaire) and the parameters of event-related EEG potentials
(ERPs). The latter potentials were recorded in the course of performance of two behavioral test tasks including motor components.
Within the framework of the “A” task, the subject is had to maximally rapidly push the button after a signal with warning
(with measurement of the latency of the sensorimotor reaction); under these conditions, we recorded the contingent negative
variation (CNV) and P300 potential. In the case of the “B” task, a definite time interval was to be measured and limited by
two pressings of the button. In this task, the readiness potential (RP) was recorded in addition to the CNV and P300. The
C3 and C4 EEG leads (according to the 10–20 system) were used. Within the framework of the “A” task, subjects belonging to
the coronary-prone type were characterized by the lowest amplitudes of the CNV and its separate components and also by greater
amplitudes and relatively long latencies of the P300 wave. Persons of type B were distinguished by the highest CNV amplitudes
in both hemispheres, while values of the P300 amplitude in this group were usually medium. In the “B” task, representatives
of type A demonstrated the lowest RP and P300 amplitudes, especially clearly pronounced negative CNVs in the left hemisphere,
and relatively long P300 latencies; individuals belonging to type B showed the highest RP and CNV amplitudes in the right
hemisphere and medium values of the P300 amplitude. The correlations found are probably due, to a considerable extent, to
the fact that both characteristics of the behavioral types A and B and amplitude parameters of ERPs depend significantly on
genetically determined neurochemical factors, namely specificities of organization and functioning of a few neurotransmitter
(in particular, aminergic) and neurohumoral systems. 相似文献
11.
The possible hydrolysis of substance P (Arg–Pro–Lys–Pro–Gln–Gln–Phe–Phe–Gly–Leu–Met) in presence of the osteoblastic cell
line SaOS-2 was measured by capillary electrophoresis coupled to mass detection. The results obtained indicate that a very
rapid disappearance of the intact undecapeptide was associated to a slower appearance of seven of its eight component amino
acids. These results can be interpreted as indicating that an extremely fast hydrolysis of substance P by endopeptidases,
which released peptidic by-products, was followed by a noticeably slower secondary degradation which released free amino acids.
In decreasing quantitative importance, these phenomena appear to originate by the hydrolysis of the Pro4–Gln5 bond, followed by C-terminal sequential degradation of the Arg1–Pro4 tetrapeptide; by the hydrolysis of or Phe7–Phe8 bond (or, possibly, of Gln6–Phe7) leading to release of free Phe and Gln; by hydrolysis of the Gly9–Leu10 bond with subsequent release of Met and Leu. Results obtained appear to be compatible with the expression by SaOS-2 cells
of enzymes already known to catalyze substance P hydrolysis, together with an apparent low efficiency of aminopeptidases.
Because of the activity of C-terminal fragments on NK1 receptors, the delay between primary hydrolysis of substance P and
secondary hydrolysis of its peptidic fragments indicated by the data shown implies a possible persistence of substance P physiological
effects even after degradation of the intact peptide. 相似文献
12.
为了明确大鼠背根节(DRG)神经元中存在慢的Ca2+激活K+电流成分,本实验在新鲜分散的DRG神经元胞体上,采用全细胞电压箝技术,给予DRG神经元一定强度的去极化刺激,记录刺激结束后30 ms时的尾电流幅度.结果发现:(1)随着去极化时间从1 ms延长至180 ms时,尾电流幅度由9.3±2.8 pA逐渐增大至64.1±3.4 pA(P<0.001);(2)当去极化结束后的复极化电位降低时,尾电流幅度先逐渐下降到零,然后改变方向,逆转电位约为-63 mV;(3)细胞外施加500μmol/L Cd2+或细胞内液中施加11 mmol/L EGYA时尾电流明显减小甚至完全消失;(4)尾电流中慢成分的幅度在细胞外给与200 nmol/L蜂毒明肽后,减小了约26.32±3.9%(P<0.01);(5)细胞外施加10 mmol/L TEA,可明显降低尾电流中的快成分.结果提示,在DRG神经元后超极化中存在Ca2+激活K+电流的蜂毒明肽敏感成分--ⅠAiHP. 相似文献
13.
The core deficit in Attention Deficit/Hyperactivity Disorder (ADHD) may be a deficiency in executive functions, particularly
the processes that are associated with the inhibition of predominant responses. To test this notion in the adult population,
healthy undergraduate volunteers and students with ADHD symptoms performed a visual Stop Signal Task (Logan et al. J Exp Psychol:
Hum Percept Perform 10:276–291, 1984) while Event-Related brain Potentials were recorded. The two groups did not differ on
behavioral measures of performance, but there was a significant difference in the N2–P3 component. These results underline
the robustness of an N2–P3 difference between healthy adults and people with ADHD symptoms that have persisted into young
adulthood. 相似文献
14.
We studied correlations of the main parameters of evoked EEG potentials (EP) with individual characteristics of attention in children and teenagers. One hundred and one healthy children (dextrals) took part in the tests. Among them, 26 and 30 children were 5 to 7 and 10 to 12 years old, while the third age group included 45 teenagers (15 to 16 years old). We recorded EP and measured the time of a sensorimotor reaction in the following experimental paradigm. Its program provided automated presentation of a pair of acoustic signals, preliminary and imperative; the subject had to perform a motor reaction, pushing a button with the right thumb, with a minimum delay after the second stimulus. Visual feedback signals informed the subject about the successful or inadequate performance of the reaction (time of reaction was shorter than or exceeded a limit value). Indices characterizing the level of attention were estimated using Find and delete and Schultes tables techniques. A well-manifested N2 component of the EP related to the preliminary signal was a specific feature in the group of 5- to 7-year-old children, while the contingent negative variation (CNV) preceding the motor reaction was poorly developed in this group. The best characteristics of attention in these and older (10 to 12 years old) children were typical of subjects with maximally expressed N1-P2 waves. In teenagers, the best attention was typical of subjects with the highest-amplitude P1 and P2 components, CNV, and P300 wave and with the lowest amplitude of the N1 component.Neirofiziologiya/Neurophysiology, Vol. 36, No. 4, pp. 313–321, July–August, 2004.This revised version was published online in April 2005 with a corrected cover date. 相似文献
15.
Martin Burger Ulrich Hoppe Peter Kummer J?rg Lohscheller Ulrich Eysholdt Michael D?llinger 《Biomedizinische Technik》2007,52(1):111-116
Event-related potentials (ERPs) as part of the EEG are applied to assess auditory processing in children. Mismatch negativity (MMN) is a change-specific component of ERPs that indicates a pre-cognitive discrimination process. MMN responses were recorded in 10 healthy preschool children to four different types of signal changes. The signals investigated were processed using a discrete wavelet transform (DWT) to analyze the characteristics of the ERP components. All children showed distinct MMN that was significant in all tasks. The MMN amplitudes varied between subjects and depended on the different tasks. The wavelet transform allowed simplified analysis and quantification of the MMN component, as well as the double-peak structure of the P1 component. The variation in MMN amplitudes suggests the possibility of determining individual auditory profiles. Owing to the shorter time required, the MMN paradigm suggested combined with the DWT proposed offers a new objective investigation method for children. 相似文献
16.
Prospective memory (PM) refers to memory for future intentions. Difference due to memory (Dm effect) is the difference in
neural activity related to stimuli that were subsequently remembered or forgotten. Using event-related potentials (ERPs),
the present study investigated the Dm effect for PM using a subsequent task-switching paradigm. The results showed that a
Dm effect of ERP P150 was more positive-going for later PM hit trials than for later PM forgotten trials during 100–200 ms.
This Dm effect may reflect the process for the production of future intention or the process for attention. Consistent with
previously reported Dm effects of other types of memory, we found that the fbN2 (250–280 ms) and late positivity component
(400–700 ms) were stronger in later PM hit trials than in forgotten trials. The fbN2 was evoked by Chinese characters. The
late positivity component was related to the precise encoding process. In conclusion, because of the early P150, PM encoding
appears to be somewhat different from previously identified Dm effects. However, further research is needed. Our findings
reveal that Dm effects of PM share similar characteristics with known Dm effects of other types of episodic memory after the
very early stage of neural processing. 相似文献
17.
Studies on the relations of selenium and Keshan disease 总被引:1,自引:0,他引:1
Xiaoshu Chen Guangqi Yang Junshi Chen Xuecun Chen Zhimei Wen Keyou Ge 《Biological trace element research》1980,2(2):91-107
Keshan disease is an endemic cardiomyopathy of unknown cause in The People’s Republic of China that occurs most frequently
in children under 15 years of age and women of child-bearing age. Studies of children 1–9 years old in Mianing County of Sichuan
Province have indicated that Keshan disease is a selenium responsive condition. Incidence rates of 9.5–13.5/1000 in 1974–1975
were reduced to 1–2/1000 in children treated with a tablet weekly of 0.5–1 mg sodium selenite. During 1974–1977, only 21 cases
of the disease occurred in 36,603 treated children, compared with 106 cases in 9430 untreated children, of whom 53 died and
5 still have insufficient heart function. Occurrence of the disease was invariably associated with a lower selenium content
of cereals, and of hair (less than 0.12 ppm Se) in residents from affected, compared with non-affected, areas. The dose relationship
between selenium and regional characteristics of Keshan disease suggests that it is probably a biogeochemical disease; other
etiological factors have also been considered. 相似文献
18.
Lupinus albus L. were grown in rhizoboxes containing a soil amended with sparingly available Fe–P or Al–P (100 μg P g−1 soil/resin mixture). Root halves of individual plants were supplied with nutrient solution (minus P) buffered at either pH 5.5
or 7.5, to assess whether the source of mineral-bound P and/or pH influence cluster-root growth and carboxylate exudation.
The P-amended soil was mixed 3:1 (w/w) with anion-exchange resins to allow rapid fixation of carboxylates. Treatments lasted 10 weeks. Forty percent and 30% of
the root mass developed as cluster roots in plants grown on Fe–P and Al–P respectively, but cluster-root growth was the same
on root-halves grown at pH 5.5 or 7.5. Mineral-bound P source (Al– or Fe–P) had no influence on the types of carboxylates
measured in soil associated with cluster roots—citrate (and trace amounts of malate and fumarate) was the only major carboxylate
detected. The [citrate] in the rhizosphere of cluster roots decreased with increased shoot P status (suggesting a systemic
effect) and also, only for plants grown on Al–P, with decreased pH in the root environment (suggesting a local effect). In
a separate experiment using anion exchange resins pre-loaded with malate or citrate, we measured malate (50%) and citrate
(79%) recovery after 30 days in soil. We therefore, also conclude that measurements of [citrate] and [malate] at the root
surface may be underestimated and would be greater than the 40- and 1.6-μmol g−1 root DM, respectively estimated by us and others because of decomposition of carboxylates around roots prior to sampling. 相似文献
19.
The system of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) may play a key role in atherogenesis of
chronic kidney disease (CKD) patients by its impact on matrix accumulation. Connections with inflammation, stress, or endothelial
dysfunction are also probable. However, the data on correlations between these parameters in CKD patients are scarce in adults
and absent in children. The aim of our study was to evaluate serum concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2, as
well as their correlations with markers of stress response (Hsp90-α, anti-Hsp60), endothelial dysfunction (sE-selectin), and
inflammation (high-sensitivity C-reactive protein) in CKD children treated conservatively. Thirty-seven patients were divided
into two groups according to the CKD stage (gr.CKDI, 19 children with CKD stages 2–3; gr.CKDII, 18 subjects with CKD stages
4–5). Twenty-four age-matched healthy subjects served as controls. Serum concentrations of MMP-2, MMP-9, TIMP-1, TIMP-2, Hsp90-α,
anti-Hsp60, and sE-selectin were assessed by ELISA. Median values of MMP-2, MMP-9, TIMP-1, and TIMP-2 were significantly higher
in all CKD children vs. controls and were increased in patients with CKD stages 4–5 vs. CKD stages 2–3. Hsp90-α, anti-Hsp60,
sE-selectin, and glomerular filtration rate predicted the values of MMPs and TIMPs. Chronic kidney disease in children is
characterized by MMP/TIMP system dysfunction, aggravated by the progression of renal failure. Correlations between examined
parameters, heat shock proteins, and markers of endothelial damage suggest the possibility of MMP/TIMP application as indicators
of stress response and atherogenesis in children with CKD on conservative treatment. 相似文献
20.
Correlations between indices of P300 EEG potential,cognitive tests,and variational pulsometry in Parkinsonian patients 总被引:1,自引:1,他引:0
The parameters of an event-related EEG potential (ERP), P300 wave, are now extensively used as objective neurophysiological
indices of the state of cognitive functions. At the same time, information on the effects of the autonomic nervous system
on the parameters of P300 is limited. In Parkinson’s disease clinics, in addition to the leading motor disorders, more or
less clear psychoemotional, cognitive, and autonomic (in particular cardiovascular) impairments are usually observed. This
allows one to study the dependence between the cardiovascular dysfunction and intensity of cognitive disorders in Parkinsonian
patients. In our study on this contingent, we analyzed correlations between the parameters of P300 potential, indices of the
state of the cognitive sphere (determined using a questionnaire, Mini Mental State Examination, MMSE, and a Luriya’s test),
and indices of variational pulsometry. Thirty-five Parkinsonian patients (49 to 74 years, severity of disease 1.5 to 3.0 by
the international classification) were examined. We found a negative influence of excessive sympathetic tonus in cardiovascular
control on the state of cognitive functions. The latency of P300 potential was longer in patients with greater intensities
of sympathetic influences on the cardiovascular system. The coefficients of correlation of the latency of P300 with the amplitude
of mode of R-R intervals (AMo), index of tension in the regulatory systems by Baevskii (IT), and index of autonomic balance
by Baevskii (IAB) were 0.52 (P < 0.01), 0.36 (P < 0.05), and 0.37 (P < 0.05), respectively. The above autonomic indices demonstrated significant negative correlations with the volume of short-term
memory measured by Luriya’s test. The P300 latency, in turn, showed negative correlations with the memory volume estimated
by the MMSE scale and Luriya’s test. With increase in the age of patients, the degree of the above-mentioned correlations
between the P300 latency, memory volume (by Luriya’s test), and parameters of variational pulsometry increased. Our data emphasize
the expedience of “routine” studies of the balance of sympathetic and parasympathetic control in pathological states accompanied
by clear or subclinical cognitive disorders. Early recognition of cardiovascular dysfunction and its corresponding therapeutic
correction should improve the state of brain functions and quality of life in patients suffering from neurodegenerative diseases,
in particular from Parkinson’s disease.
Neirofiziologiya/Neurophysiology, Vol. 40, No. 1, pp. 43–52, January–February, 2008. 相似文献