共查询到20条相似文献,搜索用时 31 毫秒
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MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) are important regulators of mRNA translation and stability in eukaryotes. While miRNAs can only bind their target mRNAs in association with Argonaute proteins (AGOs), RBPs directly bind their targets either as single entities or in complex with other RBPs to control mRNA metabolism. miRNA binding in 3′ untranslated regions (3′ UTRs) of mRNAs facilitates an intricate network of interactions between miRNA-AGO and RBPs, thus determining the fate of overlapping targets. Here, we review the current knowledge on the interplay between miRNA-AGO and multiple RBPs in different cellular contexts, the rules underlying their synergism and antagonism on target mRNAs, as well as highlight the implications of these regulatory modules in cancer initiation and progression. 相似文献
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Priyanka Patel Courtney N Buchanan Matthew D Zdradzinski Pabitra K Sahoo Amar
N Kar Seung
Joon Lee Lauren
S Vaughn Anatoly Urisman Juan Oses-Prieto Michela DellOrco Devon
E Cassidy Irene
Dalla Costa Sharmina Miller Elizabeth Thames Terika
P Smith Alma
L Burlingame Nora Perrone-Bizzozero Jeffery
L Twiss 《Nucleic acids research》2022,50(10):5772
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RNA-binding proteins and post-transcriptional gene regulation 总被引:6,自引:0,他引:6
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Rosario Francisco‐Velilla Embarc‐Buh Azman Encarnacion Martinez‐Salas 《BioEssays : news and reviews in molecular, cellular and developmental biology》2019,41(4)
The fate of cellular RNAs is largely dependent on their structural conformation, which determines the assembly of ribonucleoprotein (RNP) complexes. Consequently, RNA‐binding proteins (RBPs) play a pivotal role in the lifespan of RNAs. The advent of highly sensitive in cellulo approaches for studying RNPs reveals the presence of unprecedented RNA‐binding domains (RBDs). Likewise, the diversity of the RNA targets associated with a given RBP increases the code of RNA–protein interactions. Increasing evidence highlights the biological relevance of RNA conformation for recognition by specific RBPs and how this mutual interaction affects translation control. In particular, noncanonical RBDs present in proteins such as Gemin5, Roquin‐1, Staufen, and eIF3 eventually determine translation of selective targets. Collectively, recent studies on RBPs interacting with RNA in a structure‐dependent manner unveil new pathways for gene expression regulation, reinforcing the pivotal role of RNP complexes in genome decoding. 相似文献
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The RNA recognition motif protein CP33A is a global ligand of chloroplast mRNAs and is essential for plastid biogenesis and plant development
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Marlene Teubner Janina Fuß Kristina Kühn Kirsten Krause Christian Schmitz‐Linneweber 《The Plant journal : for cell and molecular biology》2017,89(3):472-485