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1.
Strategies for improving efficient phosphorus utilization in crops and pastures: 1. Conventional and marker assisted selection breeding; 2. Transgenic modification; 3. Optimization of P fertilization and cultivation management.
Highlights? Phosphorus efficiency is improved via conventional and marker assisted selection breeding. ? The vital genes are applied to improve P efficiency through biotech. ? Optimization of P fertilization and cultivation management improves P efficiency. ? It is vital to integrate bioengineering, P fertilization and cultivation management.  相似文献   

2.
Highlights? EBPR is a mature, effective technology to concentrate P from dilute streams. ? EBPR sludge is rich in phosphorus: it can be applied to land. ? Phosphorus in EBPR sludge can be recovered as struvite; P needs to first be solubilized. ? Solubilization of P through anaerobic digestion is attractive, but complexing with metal ions needs to be minimized.  相似文献   

3.
Highlights? Algal ponds and macrophyte wetlands in widespread use for wastewater treatment. ? Harvested algae/macrophytes require <1/10 of the area compared to terrestrial crops for phosphorus uptake. ? Luxury uptake could be used to increase the phosphorus content of the biomass. ? Multiple opportunities exist (e.g. offshore cultivation) but are still in their infancy. ? Phosphorus recovery via plants has potential to become an important future solution.  相似文献   

4.
Highlights? IGFBP-like domain structure suggests that it is incompetent for IGF binding ? Kazal-like domain structure shows distorted “P1” loop incompetent for inhibition ? Protease domain shows catalytic readiness in apo form ? SAXS envelope for full-length HtrA1  相似文献   

5.
Highlights? Group feeding animals according to their physiological state will reduce P consumption. ? Reducing P in feed and precision feeding of P will increase efficiency of P utilization by livestock. ? Addition of phytase enzyme will increase P availability especially in swine and poultry. ? Transgenic plants and animals offer a way for efficient phosphate uptake. ? Nutritional genomics is expected to improve efficiency of P utilization in livestock.  相似文献   

6.
Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression  相似文献   

7.
Phosphorus: a limiting nutrient for humanity?   总被引:2,自引:0,他引:2  
Highlights? P is essential to build key molecules, such as RNA needed for rapid growth. ? P is often limiting to productivity in ecosystems, including to crops. ? Large amounts of P are mined annually to make fertilizer to produce food. ? Current P use is unsustainable owing to ecosystem impacts and uncertainties about fertilizer production. ? A food system redesign to combine P-efficient crops with P recycling is needed.  相似文献   

8.
Highlights? Coculture with endothelial cells promotes HSC expansion and self-renewal ? Endothelial cell effect on HSCs mediated by Notch signaling ? In vivo, sinusoidal endothelial cells (SECs) express Notch ligands ? Blocking vessel remodeling impairs hematopoietic recovery after irradiation  相似文献   

9.
Highlights? GRSF1 resides in the mitochondrial matrix and is required for mitochondrial function ? GRSF1 is required for the processing of tRNA-containing and tRNA-lacking precursors ? GRSF1, RNase P, and nascent RNA are part of “mitochondrial RNA granules” ? Mitochondrial RNA granules are functionally linked to RNA processing  相似文献   

10.
Highlights? Mitochondrial fusion is regulated by independent ubiquitylation pathways ? The deubiquitylase Ubp2 promotes fusion, whereas Ubp12 inhibits fusion events ? Self-assembly and ubiquitylation cooperatively enable mitochondrial fusion ? Yeast mitofusin is sequentially ubiquitylated  相似文献   

11.
Highlights? Missing domains in PFV intasome revealed by SAXS/SANS ? PFV IN undergoes dramatic changes in conformation and oligomerization upon binding DNA ? Strand transfer inhibitors do not alter quaternary structure of PFV intasome  相似文献   

12.
Highlights? Splicing factor SF1 phosphorylation on a conserved SPSP motif is required in vivo ? SPSP phosphorylation (P) induces local folding within an SF1/U2AF65 interface ? Phosphorylation promotes an acutely bent (P)SF1/U2AF65/RNA conformation  相似文献   

13.
Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice  相似文献   

14.
Highlights? dUTPases are signaling molecules acting in analogous manner to the G proteins ? Binding to dUTP induces a conformational change in the phage-encoded dUTPases ? The dUTP-bound form of the phage dUTPases induces transfer of virulence genes ? The dUTPase P loop-like motif V is the molecular switch of the signaling mechanism  相似文献   

15.
Highlights? EM structure of the CMR complex for viral RNA degradation has been determined ? The crRNA content of CMR has been analyzed by deep sequencing ? Target RNA cleavage by CMR is sequence dependent  相似文献   

16.
Highlights? Y-family polymerases differ in fidelity and translesion synthesis specificity ? Polymerase fidelity and specificity are controlled by the interdomain linker ? Three amino acids in the interdomain linker are sufficient to determine conformation ? Differences in polymerase conformation determine differences in polymerase activity  相似文献   

17.
Highlights? Sockeye salmon use geomagnetic imprinting as a homing mechanism ? The homing route of salmon is predicted by magnetic field drift (secular variation)  相似文献   

18.
Highlights? Precise interaction mapping using substrate analogs and X-ray crystallography ? Amidation of 5′-amino-5′-deoxy-adenosine is promoted by crystallized LmNADK1 ? Structures guide fragment bridging to design a new antistaphylococcal compound  相似文献   

19.
Highlights? MBD1 governs the proliferation and differentiation of neural stem cells (NSCs) ? MBD1 controls the expression of miRNAs, including miR-184, in NSCs ? MiR-184 represses the expression of Numblike ? Numblike rescues the effects of abnormal MBD1 and miR-184 expression  相似文献   

20.
Highlights? HIV-Nef translocates activated TACE/ADAM17 into extracellular vesicles (EVs) ? The mechanism is initiated by interaction of Eed and paxillin with TACE ? Translocation of TACE into EVs is regulated by Pak2 ? Melanoma cells activate the same mechanism to upload activated ADAM10 into EVs  相似文献   

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