共查询到20条相似文献,搜索用时 62 毫秒
1.
Jiang Tian Xiurong Wang Yiping Tong Xinping Chen Hong Liao 《Current opinion in biotechnology》2012,23(6):866-871
Strategies for improving efficient phosphorus utilization in crops and pastures: 1. Conventional and marker assisted selection breeding; 2. Transgenic modification; 3. Optimization of P fertilization and cultivation management.Highlights? Phosphorus efficiency is improved via conventional and marker assisted selection breeding. ? The vital genes are applied to improve P efficiency through biotech. ? Optimization of P fertilization and cultivation management improves P efficiency. ? It is vital to integrate bioengineering, P fertilization and cultivation management. 相似文献
2.
Highlights? EBPR is a mature, effective technology to concentrate P from dilute streams. ? EBPR sludge is rich in phosphorus: it can be applied to land. ? Phosphorus in EBPR sludge can be recovered as struvite; P needs to first be solubilized. ? Solubilization of P through anaerobic digestion is attractive, but complexing with metal ions needs to be minimized. 相似文献
3.
Highlights? Algal ponds and macrophyte wetlands in widespread use for wastewater treatment. ? Harvested algae/macrophytes require <1/10 of the area compared to terrestrial crops for phosphorus uptake. ? Luxury uptake could be used to increase the phosphorus content of the biomass. ? Multiple opportunities exist (e.g. offshore cultivation) but are still in their infancy. ? Phosphorus recovery via plants has potential to become an important future solution. 相似文献
4.
Eigenbrot C Ultsch M Lipari MT Moran P Lin SJ Ganesan R Quan C Tom J Sandoval W van Lookeren Campagne M Kirchhofer D 《Structure (London, England : 1993)》2012,20(6):1040-1050
Highlights? IGFBP-like domain structure suggests that it is incompetent for IGF binding ? Kazal-like domain structure shows distorted “P1” loop incompetent for inhibition ? Protease domain shows catalytic readiness in apo form ? SAXS envelope for full-length HtrA1 相似文献
5.
Highlights? Group feeding animals according to their physiological state will reduce P consumption. ? Reducing P in feed and precision feeding of P will increase efficiency of P utilization by livestock. ? Addition of phytase enzyme will increase P availability especially in swine and poultry. ? Transgenic plants and animals offer a way for efficient phosphate uptake. ? Nutritional genomics is expected to improve efficiency of P utilization in livestock. 相似文献
6.
Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression 相似文献
7.
Jason M. Butler Daniel J. Nolan Eva L. Vertes Barbara Varnum-Finney Hideki Kobayashi Andrea T. Hooper Marco Seandel Koji Shido Ian A. White Mariko Kobayashi Larry Witte Chad May Carrie Shawber Yuki Kimura Jan Kitajewski Zev Rosenwaks Irwin D. Bernstein Shahin Rafii 《Cell Stem Cell》2010,6(3):251-264
Highlights? Coculture with endothelial cells promotes HSC expansion and self-renewal ? Endothelial cell effect on HSCs mediated by Notch signaling ? In vivo, sinusoidal endothelial cells (SECs) express Notch ligands ? Blocking vessel remodeling impairs hematopoietic recovery after irradiation 相似文献
8.
Phosphorus: a limiting nutrient for humanity? 总被引:2,自引:0,他引:2
James J Elser 《Current opinion in biotechnology》2012,23(6):833-838
Highlights? P is essential to build key molecules, such as RNA needed for rapid growth. ? P is often limiting to productivity in ecosystems, including to crops. ? Large amounts of P are mined annually to make fertilizer to produce food. ? Current P use is unsustainable owing to ecosystem impacts and uncertainties about fertilizer production. ? A food system redesign to combine P-efficient crops with P recycling is needed. 相似文献
9.
Alexis A. Jourdain Mirko Koppen Mateusz Wydro Chris D. Rodley Robert N. Lightowlers Zofia M. Chrzanowska-Lightowlers Jean-Claude Martinou 《Cell metabolism》2013,17(3):399-410
Highlights? GRSF1 resides in the mitochondrial matrix and is required for mitochondrial function ? GRSF1 is required for the processing of tRNA-containing and tRNA-lacking precursors ? GRSF1, RNase P, and nascent RNA are part of “mitochondrial RNA granules” ? Mitochondrial RNA granules are functionally linked to RNA processing 相似文献
10.
Fabian Anton Gunnar Dittmar Thomas Langer Mafalda Escobar-Henriques 《Molecular cell》2013,49(3):487-498
Highlights? Mitochondrial fusion is regulated by independent ubiquitylation pathways ? The deubiquitylase Ubp2 promotes fusion, whereas Ubp12 inhibits fusion events ? Self-assembly and ubiquitylation cooperatively enable mitochondrial fusion ? Yeast mitofusin is sequentially ubiquitylated 相似文献
11.
Kushol Gupta Joseph E. Curtis Susan Krueger Young Hwang Peter Cherepanov Frederic D. Bushman Gregory D. Van Duyne 《Structure (London, England : 1993)》2012,20(11):1918-1928
Highlights? Missing domains in PFV intasome revealed by SAXS/SANS ? PFV IN undergoes dramatic changes in conformation and oligomerization upon binding DNA ? Strand transfer inhibitors do not alter quaternary structure of PFV intasome 相似文献
12.
Wenhua Wang Alexandre Maucuer Ankit Gupta Valérie Manceau Karen R. Thickman William J. Bauer Scott D. Kennedy Joseph E. Wedekind Michael R. Green Clara L. Kielkopf 《Structure (London, England : 1993)》2013,21(2):197-208
Highlights? Splicing factor SF1 phosphorylation on a conserved SPSP motif is required in vivo ? SPSP phosphorylation (P) induces local folding within an SF1/U2AF65 interface ? Phosphorylation promotes an acutely bent (P)SF1/U2AF65/RNA conformation 相似文献
13.
María Ángeles Tormo-Más Jorge Donderis María García-Caballer Aaron Alt Ignacio Mir-Sanchis Alberto Marina José R. Penadés 《Molecular cell》2013,49(5):947-958
Highlights? dUTPases are signaling molecules acting in analogous manner to the G proteins ? Binding to dUTP induces a conformational change in the phage-encoded dUTPases ? The dUTP-bound form of the phage dUTPases induces transfer of virulence genes ? The dUTPase P loop-like motif V is the molecular switch of the signaling mechanism 相似文献
14.
Zhang J Rouillon C Kerou M Reeks J Brugger K Graham S Reimann J Cannone G Liu H Albers SV Naismith JH Spagnolo L White MF 《Molecular cell》2012,45(3):303-313
Highlights? EM structure of the CMR complex for viral RNA degradation has been determined ? The crRNA content of CMR has been analyzed by deep sequencing ? Target RNA cleavage by CMR is sequence dependent 相似文献
15.
Nikki Charles Tatsuya Ozawa Massimo Squatrito Anne-Marie Bleau Cameron W. Brennan Dolores Hambardzumyan Eric C. Holland 《Cell Stem Cell》2010,6(2):141-152
Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice 相似文献
16.
Ryan C. Wilson Meghan A. Jackson Janice D. Pata 《Structure (London, England : 1993)》2013,21(1):20-31
Highlights? Y-family polymerases differ in fidelity and translesion synthesis specificity ? Polymerase fidelity and specificity are controlled by the interdomain linker ? Three amino acids in the interdomain linker are sufficient to determine conformation ? Differences in polymerase conformation determine differences in polymerase activity 相似文献
17.
Nathan F. Putman Kenneth J. Lohmann Emily M. Putman Thomas P. Quinn A. Peter Klimley David L.G. Noakes 《Current biology : CB》2013,23(4):312-316
Highlights? Sockeye salmon use geomagnetic imprinting as a homing mechanism ? The homing route of salmon is predicted by magnetic field drift (secular variation) 相似文献
18.
Gelin M Poncet-Montange G Assairi L Morellato L Huteau V Dugué L Dussurget O Pochet S Labesse G 《Structure (London, England : 1993)》2012,20(6):1107-1117
Highlights? Precise interaction mapping using substrate analogs and X-ray crystallography ? Amidation of 5′-amino-5′-deoxy-adenosine is promoted by crystallized LmNADK1 ? Structures guide fragment bridging to design a new antistaphylococcal compound 相似文献
19.
Changmei Liu Zhao-Qian Teng Nicholas J. Santistevan Keith E. Szulwach Weixiang Guo Peng Jin Xinyu Zhao 《Cell Stem Cell》2010,6(5):433-444
Highlights? MBD1 governs the proliferation and differentiation of neural stem cells (NSCs) ? MBD1 controls the expression of miRNAs, including miR-184, in NSCs ? MiR-184 represses the expression of Numblike ? Numblike rescues the effects of abnormal MBD1 and miR-184 expression 相似文献
20.
Jung-Hyun Lee Sebastian Wittki Tanja Bräu Florian S. Dreyer Kirsten Krätzel Jochen Dindorf Ian C.D. Johnston Stefanie Gross Elisabeth Kremmer Reinhard Zeidler Ursula Schlötzer-Schrehardt Mathias Lichtenheld Kalle Saksela Thomas Harrer Gerold Schuler Maurizio Federico Andreas S. Baur 《Molecular cell》2013,49(4):668-679
Highlights? HIV-Nef translocates activated TACE/ADAM17 into extracellular vesicles (EVs) ? The mechanism is initiated by interaction of Eed and paxillin with TACE ? Translocation of TACE into EVs is regulated by Pak2 ? Melanoma cells activate the same mechanism to upload activated ADAM10 into EVs 相似文献