. Suites of analytical methods for detection and characterization of various forms of phosphorus present in biological sources.
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Highlights? We review the available methods for analyzing various forms of phosphorus. ? Biological, chemical, molecular and microscopic phosphorus analysis methods are summarized. ? Principles, advantages and limitations of each technique are discussed. ? Examples of applications for each technique are provided. 相似文献
Highlights? Ant grooming leads to mechanical removal and chemical disinfection of pathogens ? Ant poison acts as disinfectant, with formic acid as the main component ? Application occurs via grooming after oral uptake and storage of the poison ? Oral poison uptake allows decontamination of groomed brood and grooming worker 相似文献
Highlights? Oncogenic Ras drives weak growth through the PI3K canonical growth pathway ? A novel E2F-independent role for the Rb family in cell biogenesis ? Ras and loss of Rb synergize to give robust and sustained cell growth ? PI3K pathway is crucial for sustained growth, acting to maintain nutrient uptake 相似文献
Highlights? Group feeding animals according to their physiological state will reduce P consumption. ? Reducing P in feed and precision feeding of P will increase efficiency of P utilization by livestock. ? Addition of phytase enzyme will increase P availability especially in swine and poultry. ? Transgenic plants and animals offer a way for efficient phosphate uptake. ? Nutritional genomics is expected to improve efficiency of P utilization in livestock. 相似文献
Highlights? EBPR is a mature, effective technology to concentrate P from dilute streams. ? EBPR sludge is rich in phosphorus: it can be applied to land. ? Phosphorus in EBPR sludge can be recovered as struvite; P needs to first be solubilized. ? Solubilization of P through anaerobic digestion is attractive, but complexing with metal ions needs to be minimized. 相似文献
Highlights? AS160 Thr649→Ala knockin mice are made to study roles of AS160/14-3-3 interaction ? The knockin mice display impaired glucose tolerance and reduced insulin sensitivity ? Deregulated GLUT4 trafficking and glucose uptake in muscles underlie this phenotype ? These findings shed new light on understanding of the pathology of type II diabetes 相似文献
Strategies for improving efficient phosphorus utilization in crops and pastures: 1. Conventional and marker assisted selection breeding; 2. Transgenic modification; 3. Optimization of P fertilization and cultivation management.
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Highlights? Phosphorus efficiency is improved via conventional and marker assisted selection breeding. ? The vital genes are applied to improve P efficiency through biotech. ? Optimization of P fertilization and cultivation management improves P efficiency. ? It is vital to integrate bioengineering, P fertilization and cultivation management. 相似文献
Highlights? EM structure of the CMR complex for viral RNA degradation has been determined ? The crRNA content of CMR has been analyzed by deep sequencing ? Target RNA cleavage by CMR is sequence dependent 相似文献
Highlights? Acute impairment of daf-2 (insulin/IGF1) signaling causes a transient ROS signal ? Different antioxidants reduce daf-2-mediated life span extension by up to 60% ? Reduced daf-2 signaling impairs glucose uptake and promotes proline metabolism ? Nutritional supplementation with the amino acid L-proline extends life span 相似文献
Highlights? Individual mutant phenotypes in a saturation library derived via deep sequencing ? Residue depth and active-site residue derivation from mutant phenotypes ? Mutant-phenotype-derived parameters used for protein model discrimination ? Derivation of sequence-structure-function relationships without protein isolation 相似文献
Highlights? Crystallographic structure of RIG-I with 5′ triphosphorylated RNA duplex and ADP ? Solution biophysical analysis of ATP-dependent RIG-I conformational change ? The structural basis for ATP-stimulated RIG-I activation 相似文献
Highlights? AtBMI1A/B proteins prevent misexpression of embryonic traits in somatic cells ? PRC2 and AtBMI1A/B proteins maintain cells in their differentiated state ? AtBMI1A/B proteins mediate H2A monoubiquitination 相似文献
Highlights? Sockeye salmon use geomagnetic imprinting as a homing mechanism ? The homing route of salmon is predicted by magnetic field drift (secular variation) 相似文献
Highlights? Mouse pluripotent cells reprogram human B cells in heterokaryons ? ESCs lacking PRC1 or PRC2 cannot successfully reprogram ? Failure of PRC1/2-deficient ESCs to reprogram is functionally dominant ? PRC1/2 play a critical role in the chromatin reorganization required for reprogramming 相似文献
Highlights? IGFBP-like domain structure suggests that it is incompetent for IGF binding ? Kazal-like domain structure shows distorted “P1” loop incompetent for inhibition ? Protease domain shows catalytic readiness in apo form ? SAXS envelope for full-length HtrA1 相似文献
Highlights? Endosome-proteins localize to centrosomes independent of membranes ? Rab11 and its modulators localize to mother centriole appendages ? Mother centriole appendages regulate membrane recycling through Rab11 相似文献
Highlights? Top-down and bottom-up approaches to genome streamlining. ? Computational support for constructing and refactoring streamlined genomes. ? From genome engineering to metabolic reprogramming. ? Perspectives in applied genome engineering. 相似文献
