Strategies for improving efficient phosphorus utilization in crops and pastures: 1. Conventional and marker assisted selection breeding; 2. Transgenic modification; 3. Optimization of P fertilization and cultivation management.
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Highlights? Phosphorus efficiency is improved via conventional and marker assisted selection breeding. ? The vital genes are applied to improve P efficiency through biotech. ? Optimization of P fertilization and cultivation management improves P efficiency. ? It is vital to integrate bioengineering, P fertilization and cultivation management. 相似文献
Highlights? Massive neural circuit rewiring between nematodes with divergent feeding behavior ? Striking patterns correlate with known functional differences ? Motor synapse differences indicate a substantial change in information flow ? Correlates of predatory feeding behavior are identified 相似文献
Highlights? A metabolic behavior revealing a key homeostatic role for the invertebrate intestine ? Enteric neurons couple reproductive state with intestinal physiology ? An insulinergic brain-gut neuronal circuit adjusts feeding to nutritional conditions ? A vasopressin-like system of central neurons is essential for water homeostasis 相似文献
Highlights? Agricultural intensification promotes P loss and poor P use efficiency. ? Losses are enriched in soils with poor P retention and subject to frequent runoff. ? Strategies to prevent loss need to focus on specific farming systems. ? The effectiveness of strategies is better if applied to critical source areas (CSAs), but may never reach a reference state. ? A greater focus on farming areas naturally resilient to P loss is warranted. 相似文献
Highlights? SFA can aid sustainable P management in response to P scarcity and pollution. ? 18 recent P SFAs are assessed at different scales to identify P ‘hotspots’. ? Context-specific analyses are important to quantify P flows in a given system. ? Regardless of scale, P is lost from all sectors between mine, field and fork. ? Losses in the mining/fertilizer and food processing sectors must not be overlooked. ? P use efficiency and recovery is needed in mining, agriculture, food, household and waste sectors. 相似文献
Highlights? Nitrogen homeostasis exhibits circadian rhythmicity in mammals ? Klf 15 regulates rhythmic amino acid utilization and ammonia detoxification ? Krüppel-like factor 15 is regulated by the circadian clock ? Feeding is a major external cue regulating Klf15 rhythmicity and nitrogen homeostasis 相似文献
Highlights? Phosphorus (P) ineffluent can be removed by biological/chemical-driven adsorption and precipitation. ? Phosphorus adsorption by filters and struvite formation are promising options in this field. ? Emerging adsorption approaches include P removal by polymers/nanomaterials. 相似文献
Highlights? DAF-16 regulates genes both cell autonomously and cell nonautonomously ? DAF-16 can act at in the endoderm to delay muscle aging ? DAF-16 can act at a distance to protect animals from amyloid paralysis ? Cell-non-autonomous gene regulation by DAF-16 involves the lipid-gene regulator MDT-15 相似文献
Highlights? Irp1 deficiency causes polycythemia and pulmonary hypertension ? Irp1 regulates HIF2α translation and expression of EPO and endothelin 1 ? Irp1 represses erythropoiesis to protect tissue iron levels during iron deficiency ? A low-iron diet worsens polycythemia and causes sudden death in Irp1?/? animals 相似文献
Highlights? Vervet monkeys (one captive, two wild groups) solved a multiplayer coordination problem ? All those dominant to food provider had to leave “forbidden circle” around dispenser ? The animals discovered all fundamentals of the game structure without human guidance ? Individual learning and patience, rather than communication or coercion, were decisive 相似文献
Highlights? Correct dosage of chromosome 12-imprinted genes is essential for postnatal survival ? Disruption of Dlk1 and Dio3 imprinting causes failure to adapt to independent life ? Maximal brown adipose activity is required as animals first leave the nest ? Dlk1 and Dio3 regulate maturation of brown adipose tissue 相似文献
Highlights? IGFBP-like domain structure suggests that it is incompetent for IGF binding ? Kazal-like domain structure shows distorted “P1” loop incompetent for inhibition ? Protease domain shows catalytic readiness in apo form ? SAXS envelope for full-length HtrA1 相似文献
Highlights? P is essential to build key molecules, such as RNA needed for rapid growth. ? P is often limiting to productivity in ecosystems, including to crops. ? Large amounts of P are mined annually to make fertilizer to produce food. ? Current P use is unsustainable owing to ecosystem impacts and uncertainties about fertilizer production. ? A food system redesign to combine P-efficient crops with P recycling is needed. 相似文献
Highlights? Combinatorial mutagenesis at four remote sites shifts reaction coordinate stabilities ? Cooperative action of all four sites accounts for the entire catalytic role of Mg2+ ? Catalysis of ATP utilization by Mg2+ occurs if, and only if, the conformation changes ? This type of allosteric effect may explain vectorial coupling in transducing NTPases 相似文献
Highlights? EBPR is a mature, effective technology to concentrate P from dilute streams. ? EBPR sludge is rich in phosphorus: it can be applied to land. ? Phosphorus in EBPR sludge can be recovered as struvite; P needs to first be solubilized. ? Solubilization of P through anaerobic digestion is attractive, but complexing with metal ions needs to be minimized. 相似文献
Highlights? TYPHON explores a protein's conformational space under given nonlocal restraints ? TYPHON's advanced probabilistic models ensure protein-like local structure ? TYPHON can reproduce a range of experimental results ? TYPHON's computational efficiency makes large scale screening efforts possible 相似文献
Highlights? Mpl loss increases γ-irradiation-induced genomic instability in HSPCs ? TPO promotes DNA repair in vitro and in vivo in HSPCs ? TPO increases DNA-PK activity and NHEJ-mediated repair efficiency in HSPCs ? A single TPO injection before mouse TBI limits long-term HSC injury and mutagenesis 相似文献
Highlights? dUTPases are signaling molecules acting in analogous manner to the G proteins ? Binding to dUTP induces a conformational change in the phage-encoded dUTPases ? The dUTP-bound form of the phage dUTPases induces transfer of virulence genes ? The dUTPase P loop-like motif V is the molecular switch of the signaling mechanism 相似文献
Highlights? GRSF1 resides in the mitochondrial matrix and is required for mitochondrial function ? GRSF1 is required for the processing of tRNA-containing and tRNA-lacking precursors ? GRSF1, RNase P, and nascent RNA are part of “mitochondrial RNA granules” ? Mitochondrial RNA granules are functionally linked to RNA processing 相似文献
