共查询到20条相似文献,搜索用时 15 毫秒
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Cytochrome b-245 from neutrophil plasma membranes contains two types of subunit with apparent molecular masses from gel electrophoresis in the presence of SDS of 23 kDa and 76-92 kDa. Radiation-inactivation analysis revealed a single-exponential decay process for the visible absorption of the haem chromophore in the membrane, corresponding to a molecular mass of 21 +/- 5 kDa for the haem-containing polypeptide chain. Sedimentation equilibrium of the cytochrome solubilized by the detergent Triton N101 showed that the protein was polydisperse, with a molecular mass of approx. 350 kDa for the smallest detectable species. In another detergent, n-octyl beta-O-glucopyranoside (octyl glucoside), the molecular mass of the haem-containing particle was found to be 20-30 kDa. Thus the quaternary structure of the protein breaks down in this detergent. The haem group is inferred to be attached to the smaller subunit. 相似文献
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Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action 总被引:5,自引:0,他引:5
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Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocycles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of -0.3 to -0.9 V. Catalytic production of oxidative pressure from redox cycling involving oxygen is believed to be an important mode of action by the medicinal agents. Literature data contribute support. 相似文献
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Background Inflammatory processes with a range of specialized cells and biochemical mediators form a complex network of inter-related
signal transducing pathways that relay information to preserve normal functions. Advances in molecular analyses of the information
relay pathways for their constituents and principal ligands along with mechanisms utilized by the host for microbial recognition
have stimulated interest in therapeutic agents with dual functionalities i.e. antibacterial and anti-inflammatory effects.
Aim This review examines clinically tested agents for oral health applications with both antimicrobial and anti-inflammatory
effects to include antibiotics, antimicrobials and phenolics. Results Bis-phenols such as triclosan, representing a unique dual functional therapeutic for routine oral hygiene, with its demonstrated
clinical effects on inhibiting the dental plaque biofilm, reducing inflammation (gingivitis) and subsequent periodontitis
is described. Cyclines, comprising another class of approved anti-inflammatory agents used at the patient level for oral health
is discussed. Dual active agents in current clinical practice for systemic conditions are highlighted to summarize the clinical
validity of dual function agents as an emerging therapeutic strategy. Conclusions Clinical studies demonstrate therapeutic benefits of agents with dual functionality with their effects on microorganisms
and the concomitant host inflammatory response. Advances in microbial pathogenesis and resultant inflammation will facilitate
progress in this emerging area poised to be a significant milestone for dental therapeutics 相似文献
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Inhibitors of protein biosynthesis. II. Mode of action of anisomycin 总被引:16,自引:0,他引:16
A P Grollman 《The Journal of biological chemistry》1967,242(13):3226-3233
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We prepared insulin-liposomes using one combination of lipids including phosphatidylcholine (cholesterol) stearylamine, 7/2/1 (molar ratio). Non-sonicated liposomes (LMV) and sonicated liposomes (SUV) contained about 20% and 5% of insulin, respectively. Free insulin was removed from liposomes-associated insulin by ultracentrifugation, or ultrafiltration on Sepharose 6B column. Insulin preparations were administered parenterally and non-parenterally into male, Wistar rats with alloxan diabetes to produce the hypoglycaemia. In case of i.v. and s.c. routes of administration all preparations acted in the similar manner giving the clear hypoglycaemia after 2 h. When administered intragastrically only liposome insulin caused hypoglycaemia. In case of buccal and nasal routes of administration only SUV-insulin was effective. 相似文献