共查询到20条相似文献,搜索用时 15 毫秒
1.
Maternal occupational pesticide exposure and risk of congenital heart defects in the national birth defects prevention study 下载免费PDF全文
Carissa M. Rocheleau Stephen J. Bertke Christina C. Lawson Paul A. Romitti Wayne T. Sanderson Sadia Malik Philip J. Lupo Tania A. Desrosiers Erin Bell Charlotte Druschel Adolfo Correa Jennita Reefhuis the National Birth Defects Prevention Study. 《Birth defects research. Part A, Clinical and molecular teratology》2015,103(10):823-833
2.
Philip J. Lupo Elaine Symanski Peter H. Langlois Christina C. Lawson Sadia Malik Suzanne M. Gilboa Laura J. Lee A. J. Agopian Tania A. Desrosiers Martha A. Waters Paul A. Romitti Adolfo Correa Gary M. Shaw Laura E. Mitchell and the National Birth Defects Prevention Study 《Birth defects research. Part A, Clinical and molecular teratology》2012,94(11):875-881
BACKGROUND: There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case‐control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. METHODS: Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self‐reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring. RESULTS: The prevalence of occupational PAH exposure was 4.0% in CHD case mothers (76/1907) and 3.6% in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95% confidence interval [CI], 0.58–1.67), septal defects (AOR, 1.28; 95% CI, 0.86–1.90), or with any isolated CHD subtype. CONCLUSIONS: Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population‐based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism. Birth Defects Research (Part A), 2012. © 2012 Wiley Periodicals, Inc. 相似文献
3.
Kara N. D. Polen Sonja A. Rasmussen Tiffany Riehle‐Colarusso Jennita Reefhuis and the National Birth Defects Prevention Study 《Birth defects research. Part A, Clinical and molecular teratology》2013,97(1):28-35
BACKGROUND
Few epidemiologic studies have investigated the use of venlafaxine (Effexor XR capsules, Product Monograph, Wyeth, Montreal, Canada), an antidepressant used to treat major depression and anxiety disorders in adults, during pregnancy. Our objective was to determine whether use of venlafaxine during pregnancy is associated with specific birth defects.METHODS
We used data from the National Birth Defects Prevention Study (NBDPS), a population‐based, case‐control study in the United States. Our analysis included mothers with pregnancies affected by one of 30 selected birth defects (cases) and babies without birth defects (controls) with estimated dates of delivery between 1997 and 2007. Exposure was any reported use of venlafaxine from 1 month preconception through the third month of pregnancy. We calculated adjusted odds ratios (aORs) and 95% Fisher Exact confidence intervals (CIs) for 24 birth defect groups for which at least 400 case mothers were interviewed. Our adjusted analyses controlled for maternal age and race/ethnicity.RESULTS
Among the 27,045 NBDPS participants who met inclusion criteria, 0.17% (14/8002) of control mothers and 0.40% (77/19,043) of case mothers reported any use of venlafaxine from 1 month preconception through the third month of pregnancy. Statistically significant associations were found for anencephaly, atrial septal defect (ASD) secundum, or ASD not otherwise specified, coarctation of the aorta, cleft palate, and gastroschisis.CONCLUSIONS
Our data suggest associations between periconceptional use of venlafaxine and some birth defects. However, sample sizes were small, CIs were wide, and additional studies are needed to confirm these results. Birth Defects Research (Part A), 2013. © 2012 Wiley Periodicals, Inc. 相似文献4.
Mayura U. Shinde Ann M. Vuong Jean D. Brender Martha M. Werler Katherine E. Kelley John C. Huber Jr Joseph R. Sharkey Qi Zheng Lucina Suarez Peter H. Langlois Mark A. Canfield Paul A. Romitti Sadia Malik The National Birth Defects Prevention Study 《Birth defects research. Part A, Clinical and molecular teratology》2013,97(8):515-531
5.
Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort 下载免费PDF全文
Kristen M. Rappazzo Joshua L. Warren Robert E. Meyer Amy H. Herring Alison P. Sanders Naomi C. Brownstein Thomas J. Luben 《Birth defects research. Part A, Clinical and molecular teratology》2016,106(4):240-249
6.
7.
Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the national birth defects prevention study 下载免费PDF全文
Jacqueline L. O'Brien Peter H. Langlois Christina C. Lawson Angela Scheuerle Carissa M. Rocheleau Martha A. Waters Elaine Symanski Paul A. Romitti A.J. Agopian Philip J. Lupo the National Birth Defects Prevention Study 《Birth defects research. Part A, Clinical and molecular teratology》2016,106(1):55-60
8.
9.
10.
11.
12.
Differences in risk factors for second and third degree hypospadias in the national birth defects prevention study 下载免费PDF全文
Sander Groen in 't Woud Iris A.L.M. van Rooij Marleen M.H.J. van Gelder Richard S. Olney Suzan L. Carmichael Nel Roeleveld Jennita Reefhuis the National Birth Defects Prevention Study 《Birth defects research. Part A, Clinical and molecular teratology》2014,100(9):703-711
13.
Preconceptional folic acid‐containing supplement use in the national birth defects prevention study 下载免费PDF全文
Zeina G. Khodr Philip J. Lupo A.J. Agopian Mark A. Canfield Amy P. Case Suzan L. Carmichael Laura E. Mitchell 《Birth defects research. Part A, Clinical and molecular teratology》2014,100(6):472-482
Background: Despite public health campaigns encouraging women to take a daily folic acid supplement, the proportion of reproductive age women, in the United States, who comply with this recommendation is less than optimal. The objective of this analysis was to identify predictors of preconceptional folic acid‐containing supplement use to define subgroups of women who may benefit from targeted folic acid campaigns. Methods: This study included 6570 mothers of live born infants from the control population of National Birth Defects Prevention Study (1997–2005). Logistic regression analyses were used to identify predictors of preconceptional folic acid supplementation. A classification and regression tree (CART) analysis was used to define subgroups of women with different patterns of preconceptional folic acid supplementation. Results: Race/ethnicity, education, age at delivery, nativity, employment, income, number of dependents, smoking, and birth control use were significantly associated with preconceptional folic acid‐containing supplement use. Based on a CART analysis, education, race/ethnicity, and age were the most distinguishing factors between women with different preconceptional supplementation patterns. Non‐white women with <4 years of a college education were the least likely to use folic acid‐containing supplements (11%). However, even in the most compliant subgroup (women with ≥4 years of college), only 60% of women supplemented with folic acid. Conclusion: These results demonstrate the need for continued efforts to increase folic acid supplementation among all reproductive aged women. However, the success of such efforts may be improved if maternal characteristics such as education, race/ethnicity, and age, are considered in the development of future interventions. Birth Defects Research (Part A) 100:472–482, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
14.
Marilyn L. Browne Sonja A. Rasmussen Adrienne T. Hoyt D. Kim Waller Charlotte M. Druschel Alissa R. Caton Mark A. Canfield Angela E. Lin Suzan L. Carmichael Paul A. Romitti 《Birth defects research. Part A, Clinical and molecular teratology》2009,85(7):621-628
BACKGROUND: Although thyroid disorders are present in approximately 3% of pregnant women, little is known about the association between maternal thyroid disease and birth defects. METHODS: We assessed the association between maternal thyroid disease, thyroid medication use, and 38 types of birth defects among 14,067 cases and 5875 controls in the National Birth Defects Prevention Study, a multisite, population‐based, case‐control study. Infants in this study were born between October 1997 and December 2004. Information on exposures including maternal diseases and use of medications was collected by telephone interview. RESULTS: We found statistically significant associations between maternal thyroid disease and left ventricular outflow tract obstruction heart defects (1.5; 95% CI, 1.0–2.3), hydrocephaly (2.9; 95% CI, 1.6–5.2), hypospadias (1.6; 95% CI, 1.0–2.5), and isolated anorectal atresia (2.4; 95% CI, 1.2–4.6). Estimates for the association between periconceptional use of thyroxine and specific types of birth defects were similar to estimates for any thyroid disease. Given that antithyroid medication use was rare, we could not adequately assess risks for their use for most case groups. CONCLUSIONS: Our results are consistent with the positive associations between maternal thyroid disease or thyroid medication use and both hydrocephaly and hypospadias observed in some previous studies. New associations with left ventricular outflow tract obstruction heart defects and anorectal atresia may be chance findings. Birth Defects Research (Part A), 2009. © 2009 Wiley‐Liss, Inc. 相似文献
15.
Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines 总被引:1,自引:0,他引:1
Munger RG Sauberlich HE Corcoran C Nepomuceno B Daack-Hirsch S Solon FS 《Birth defects research. Part A, Clinical and molecular teratology》2004,70(7):464-471
BACKGROUND: Vitamin deficiencies induce oral clefts in animal experiments, but the role of specific nutrients in human oral clefts is uncertain. METHODS: Associations between maternal vitamin B-6 and folate status and risk of nonsyndromic cleft lip, with or without cleft palate (CL/P), were examined in case-control studies at two sites in the Philippines--Negros Occidental and Davao. Cases were mothers of affected children and control mothers were those who had no children with oral clefts. RESULTS: The risk of having a CL/P-affected child increased with increasing tertile of vitamin B-6 deficiency in both Negros Occidental and Davao (odds ratios [ORs] and 95% confidence intervals [CIs] for sites combined = 1.0 [reference], OR, 2.94; 95% CI, 1.51-5.73; OR, 4.98; 95% CI, 2.56-9.67). Poor B-6 status had a stronger association with CL/P among mothers with lower versus higher plasma folate levels. Increasing tertiles of plasma folate were marginally associated with an increased risk of clefts in both sites combined (1.0 [reference]; OR, 1.58; 95% CI, 0.93-2.68; OR, 1.59; 95% CI, 0.94-2.70). Increasing tertiles of erythrocyte folate were associated with a decreased risk of CL/P in Negros Occidental (1.0 [reference]; OR, 0.34; 95% CI, 0.13-0.90; OR, 0.46; 95% CI, 0.20-1.09) and an increased risk in Davao (1.0 [reference]; OR, 1.23; 95% CI, 0.54-2.81; OR, 4.85; 95% CI, 2.24-10.50). The inconsistent associations between folate status and CL/P risk appeared to be a result of statistical interaction between folate, vitamin B-6, and case-control status that produced different results in study areas of higher versus lower prevalence of vitamin B-6 deficiency. CONCLUSIONS: Poor maternal vitamin B-6 status was consistently associated with an increased risk of CL/P at two sites in the Philippines. Folate-CL/P associations were inconsistent and may be related to the vitamin B-6 status or other characteristics of the populations under study. 相似文献
16.
17.
18.
19.
Wurst KE Ephross SA Loehr J Clark DW Guess HA 《Birth defects research. Part A, Clinical and molecular teratology》2007,79(4):309-316
BACKGROUND: As part of an effort to validate the General Practice Research Database (GPRD) for future studies of medication use in pregnancy, this study examined whether the rates of all, and specific types of, congenital heart defects obtained from the GPRD are similar to those obtained from UK national systems. METHODS: The prevalence rates of heart defects for 2001-2003 were determined from the GPRD and compared with both the National Congenital Anomaly System (NCAS) and the European Concerted Action of Congenital Anomalies and Twins (EUROCAT). Rate ratios (RRs) and 95% CIs were calculated comparing the prevalence of all congenital heart defects as well as specific types of heart defects in the three data sources. In addition, the effect of the child's age on the frequency of heart defects in the GPRD was determined. RESULTS: The prevalence of heart defects in the GPRD was more than twice as high as in the NCAS and slightly higher than in the EUROCAT. All differences were statistically significant. The prevalence of specific heart defects varied across the GPRD, NCAS, and EUROCAT. The measured prevalence of congenital heart defects in the GPRD was higher if calculated including children up to age 6. CONCLUSIONS: The comparisons of the GPRD prevalence rates to national prevalence estimates demonstrate that the GPRD can serve as a more complete source of background prevalence for the most commonly occurring congenital heart defects, which is essential to properly assess possible associations between maternal exposures and congenital heart defects. 相似文献