共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties 总被引:1,自引:0,他引:1
Bouhlel MA Derudas B Rigamonti E Dièvart R Brozek J Haulon S Zawadzki C Jude B Torpier G Marx N Staels B Chinetti-Gbaguidi G 《Cell metabolism》2007,6(2):137-143
Th1 cytokines promote monocyte differentiation into proatherogenic M1 macrophages, while Th2 cytokines lead to an "alternative" anti-inflammatory M2 macrophage phenotype. Here we show that in human atherosclerotic lesions, the expression of M2 markers and PPARgamma, a nuclear receptor controlling macrophage inflammation, correlate positively. Moreover, PPARgamma activation primes primary human monocytes into M2 differentiation, resulting in a more pronounced anti-inflammatory activity in M1 macrophages. However, PPARgamma activation does not influence M2 marker expression in resting or M1 macrophages, nor does PPARgamma agonist treatment influence the expression of M2 markers in atherosclerotic lesions, indicating that only native monocytes can be primed by PPARgamma activation to an enhanced M2 phenotype. Furthermore, PPARgamma activation significantly increases expression of the M2 marker MR in circulating peripheral blood mononuclear cells. These data demonstrate that PPARgamma activation skews human monocytes toward an anti-inflammatory M2 phenotype. 相似文献
4.
5.
6.
7.
8.
9.
Chair of Committee for Mouse Chromosome 18 相似文献
10.
11.
12.
13.
Chair of Committee for Mouse Chromosome 2 相似文献
14.
15.
16.
17.
18.
19.
20.
Eugene M. Rinchik Terry Magnuson Bernadette Holdener-Kenny Gavin Kelsey Albert Bianchi Claudio J. Conti Fran?ois Chartier Kathryn A. Brown Stephen D. M. Brown Josephine Peters 《Mammalian genome》1992,3(Z1):S104-S120
Chair of Committee for Mouse Chromosome 7 相似文献