共查询到20条相似文献,搜索用时 46 毫秒
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U. Grünewald 《International Review of Hydrobiology》1991,76(3):473-474
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Middleton DS Andrews M Glossop P Gymer G Jessiman A Johnson PS Mackenny M Pitcher MJ Rooker T Stobie A Tang K Morgan P 《Bioorganic & medicinal chemistry letters》2006,16(5):1434-1439
A series of sertraline analogues 4-39 which possess polar groups on the fused tetrahydronaphthalene ring, targeting reduced V(d) as a strategy to reduce T(max) and increase rate of elevation of central 5-HT levels, were prepared. These studies led to the successful identification of 22a, which demonstrated equivalent pharmacology and metabolic stability to 1, but which possessed greatly reduced V(d) leading to significantly shorter T(max), in rat pharmacokinetic studies. 相似文献
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H. Drfel 《Biometrical journal. Biometrische Zeitschrift》1969,11(6):425-426
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H. Horn 《International Review of Hydrobiology》1992,77(1):170-170
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