重度烧伤患者细菌感染菌群分布及影响因素

目的 探讨重度烧伤患者细菌感染的菌群分布并分析其影响因素。 方法 选取我院2017年1月-2019年1月收治的重度烧伤患者212例,普通培养烧伤后10~15 d创面分泌物,观察细菌感染菌群分布情况,并从性别、年龄、烧伤深度、烧伤面积、低蛋白血症、糖尿病、早期休克、延迟复苏、血红蛋白尿、吸入性损伤、抗菌药物使用等方面分析重度烧伤患者感染的影响因素。 结果 212例重度烧伤患者中有89例患者发生创面感染,感染率为41.98％。89例发生创面细菌感染患者中:26例感染鲍氏不动杆菌,占29.21％;20例感染金黄色葡萄球菌,占22.47％;17例感染铜绿假单胞菌,占19.10％;12例感染肺炎克雷伯菌,占13.48％;8例感染大肠杆菌,占8.99％;4例感染变形杆菌,占4.49％;2例感染不动杆菌,占2.25％。影响重度烧伤患者细菌感染的单因素有烧伤面积、低蛋白血症、糖尿病、早期休克、延迟复苏、吸入性损伤(P结论 重度烧伤患者易发生细菌感染,感染影响因素有烧伤面积、低蛋白血症、糖尿病、早期休克、延迟复苏、吸入性损伤,临床应针对危险因素积极采取防治措施,控制细菌感染发生率,促进患者康复。     

Blood middle-molecule peptides as factors in the modification of the erythrocyte membrane in burns

The electrophoretic mobility (EM) and acid stability of erythrocytes were investigated during incubation in a middle-molecule peptide-containing medium and in burns of different severity. It was shown, that EM of erythrocytes markedly increased after thermal injury. Major part of MMP fractions produced the same effect during in vitro incubation. MMP also changed the erythrocyte stability to acid haemolytic.     

Study of the nature of toxic factors in burns on sterile guinea pigs]

Experiments were conducted on sterile and contaminated guinea pigs. The toxicity of the serum and the water-salt extracts of the internal organs after the burn was studied by the action on the leukocyte migration in a culture. Despite the complete absence of the microbial flora, the toxic properties of the serum and of the extracts of the internal organs of the sterile animals were the same as in the contaminated organs. The data obtained pointed to the important role of the histiogenic factors in the development of burn intoxication.     

Prions and Related Phenomena

The second issue of Prion, which we are happily presenting to the reader, is further emphasizing our general strategy of covering prions and related phenomena in different experimental settings, with the attention to both biological roles and clinical applications.