共查询到20条相似文献,搜索用时 151 毫秒
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Yuan Zhuang Robert J. Barndt Lihua Pan Robert Kelley Meifang Dai 《Molecular and cellular biology》1998,18(6):3340-3349
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A class of helix-loop-helix (HLH) proteins, including E2A (E12 and E47), E2-2, and HEB, that bind in vitro to DNA sequences present in the immunoglobulin (Ig) enhancers has recently been identified. E12, E47, E2-2, and HEB are each present in B cells. The presence of many different HLH proteins raises the question of which of the HLH proteins actually binds the Ig enhancer elements in B cells. Using monoclonal antibodies specific for both E2A and E2-2, we show that both E2-2 and E2A polypeptides are present in B-cell-specific Ig enhancer-binding complexes. E2-box-binding complexes in pre-B cells contain both E2-2 and E2A HLH subunits, whereas in mature B cells only E2A gene products are present. We show that the difference in E2-box-binding complexes in pre-B and mature B cells may be caused by differential expression of E2A and E2-2. 相似文献
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Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors 总被引:6,自引:0,他引:6
Kee BL 《Journal of immunology (Baltimore, Md. : 1950)》2005,175(7):4518-4527
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