共查询到20条相似文献,搜索用时 15 毫秒
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神经肽Y(neuropeptide Y,NPY)是一种由36个氨基酸残基组成的肽类激素,属胰多肽家族,广泛分布于中枢及外周神经组织的神经元中。NPY主要参与摄食行为、心血管活动、垂体分泌等生理功能的调节。NPY还参与了痛觉调制。NPY受体有Y1、Y2、Y3、Y4、Y5和Y6六种亚型。目前对Y1受体和Y2受体的研究较多,显示Y1受体和Y2受体参与痛觉调制。但现在对NPY在痛觉中的具体作用机制还不清楚。该文对NPY及其Y1受体、Y2受体在痛觉调制中的作用作一概述。 相似文献
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《Journal of receptor and signal transduction research》2013,33(4):351-360
AbstractNeuropeptide Y (NPY) recognition by the human neuroblastoma cell lines SiMa, Kelly, SH‐SY5Y, CHP‐234, and MHH‐NB‐11 was analyzed in radioactive binding assays using tritiated NPY. For the cell lines CHP‐234 and MHH‐NB‐11 binding of [3H]propionyl‐NPY was observed with Kd‐values of 0.64 ± 0.07 nM and 0.53 ± 0.12 nM, respectively, determined by saturation analysis with non‐linear regression. The receptor subtype was determined by competition analysis using the subtype selective NPY analogues [Leu31, Pro34]‐NPY (NPY‐Y1, NPY‐Y5), [Ahx5‐24]‐NPY (NPY‐Y2), [Ala31, Aib32]‐NPY (NPY‐Y5), NPY [3‐36] (NPY‐Y2, NPY‐Y5), and NPY [13‐36] (NPY‐Y2). Both cell lines, CHP‐234 and MHH‐NB‐11, the latter one being characterized for NPY receptors for the first time, showed exclusive expression of NPY‐Y2 receptors. In both cell lines binding of NPY induced signal transduction, which was monitored as reduction of forskolin‐induced cAMP production in an ELISA. 相似文献
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目的:观察精子数目异常与小Y染色体及内分泌性腺激素水平。方法:对262名少精及无精症患者检测染色体,并对其中11例小Y染色体及随机抽取的15例Y染色体正常的患者运用磁性分离酶免疫测定法分别检测性腺激素。结果:小Y染色体检出率为4.19%(11/262),其内分泌性腺激素均呈高卵泡刺激素、高黄体生成素和低睾酮水平,与Y染色体正常的无精及少精症患者相比较,差异有显著性(P<0.05)。而小Y染色体不同精子数组各内分泌性腺激素比较,差异无显著性(P>0.05)。结论:精子数目异常可能与小Y染色体有关,小Y染色体基因改变可能是导致其内分泌性腺激素的变化因素。 相似文献
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目的:观察精子数目异常与小Y染色体及内分泌性腺激素水平。方法:对262名少精及无精症患者检测染色体,并对其中11例小Y染色体及随机抽取的15例Y染色体正常的患者运用磁性分离酶免疫测定法分别检测性腺激素。结果:小Y染色体检出率为4.19%(11/262),其内分泌性腺激素均呈高卵泡刺激素、高黄体生成素和低睾酮水平,与Y染色体正常的无精及少精症患者相比较.差异有显著性(P〈0.05)。而小Y染色体不同精子数组各内分泌性腺激素比较,差异无显著性(P〉0.05)。结论:精子数目畀常可能与小Y染色体有关,小Y染色体基因改变可能是导致其内分泌性腺激素的变化因素。 相似文献
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McElreavey K Chantot-Bastaraud S Ravel C Mandelbaum J Siffroi JP 《Journal de la Société de Biologie》2008,202(2):135-141
The human Y chromosome contains a number of genes and gene families that are essential for germ cell development and maintenance. Many of these genes are located in highly repetitive elements that are subject to rearrangements. Deletion of azoospermia factor (AZF) regions AZFa, AZFb, and AZFc are found in approximately 10-15% of men with severe forms of spermatogenic failure. Several partial AZFc deletions have been described. One of these, which removes around half of all the genes within the AZFc region, appears to be present as an inconsequential polymorphism in populations of northern Eurasia. A second deletion, termed gr/gr, also results in the absence of several AZFc genes and it may be a genetic risk factor for spermatogenic failure. However, the link between these partial deletions and fertility is unclear. The gr/gr deletion is not a single deletion but a combination of deletions that vary in size and complexity and result in the absence of different genes. There are also regional or ethnic differences in the frequency of gr/gr deletions. In some Y-chromosome lineages, these deletions appear to be fixed and may have little influence on spermatogenesis. Most of these data (gene content and Y chromosome structure) have been deduced from the reference Y chromosome sequence deposited in NCBI. However, recently there have been attempts to define these types of structural rearrangements in the general population. These have highlighted the considerable degree of structural diversity that exist. Trying to correlate these changes with the phenotypic variability is a major challenge and it is likely that there will not be a single reference (or normal) Y chromosome sequence but many. 相似文献
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P2Y 受体研究进展 总被引:4,自引:0,他引:4
P2受体作为一类核苷酸受体,可分为门控离子通道P2X受体和G蛋白偶联P2Y受体。P2Y受体在人体内分布广泛,功能复杂,迄今为止已从人体组织细胞克隆出9种P2Y受体,分别为P2Y1,2,4,6,11,1,13,14,15受体。本文对P2Y受体的结构特征、生理功能、药理特性和临床应用进行综述。 相似文献
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神经肽Y(neuropeptide tyrosine,NPY)是最近从哺乳动物脑组织中提取出来的一种新的脑多肽。它由36个氨基酸残基组成,其氨基酸排列顺序与另外二个存在于肠道内分泌细胞中的调节肽——胰多肽(PP)和酪酪肽(PYY)很相似,但NPY只存在于哺乳动物的中枢和外周神经组织中,尚未在内分泌细胞中发现。最近,英国科学家Polak等,用生物化学和细胞免疫化学方法证明,在小鼠、大鼠、豚鼠、狗和马 相似文献
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神经肽Y对心血管的作用 总被引:21,自引:0,他引:21
神经肽Y(NPY)广泛分布于心脏和血管周围,主要存在于外周交感神经中,并由交感神经末梢分泌。它具有收缩血管的作用,还能增强交感神经递质等缩血管活性物质以及抑制舒血管活性物质的作用.在病理状况下可能是引起血管痉挛的因素之一。 相似文献
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神经肽Y对心脏的作用 总被引:1,自引:0,他引:1
神经肽Y(NPY)广泛分布于心脏各个部位,主要与去甲肾上腺素共存于交感神经。当交感神经兴奋时,由末梢释放。NPY对心脏具有直接的变力、变时和电生理作用,可影响细胞的信号转导,调制心脏自主神经递质的释放,并参与心脏的自主神经调节。NPY在心脏的生理学和病理生理学上具有重要意义。 相似文献