共查询到20条相似文献,搜索用时 0 毫秒
1.
2.
3.
4.
5.
Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. 下载免费PDF全文
Dai Wang Cynthia de la Fuente Longwen Deng Lai Wang Irene Zilberman Carolyn Eadie Marlene Healey Dana Stein Thomas Denny Lawrence E. Harrison Laurent Meijer Fatah Kashanchi 《Journal of virology》2001,75(16):7266-7279
6.
7.
8.
Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation 下载免费PDF全文
Wei BL Arora VK Raney A Kuo LS Xiao GH O'Neill E Testa JR Foster JL Garcia JV 《Journal of virology》2005,79(23):14976-14980
The accessory human immunodeficiency virus type 1 (HIV-1) protein Nef activates the autophosphorylation activity of p21-activated kinase 2 (PAK2). Merlin, a cellular substrate of PAK2, is homologous to the ezrin-radixin-moesin family and plays a critical role in Rac signaling. To assess the possible impact on host cell metabolism of Nef-induced PAK2 activation, we investigated the phosphorylation of merlin in Nef expressing cells. Here we report that Nef induces merlin phosphorylation in multiple cell lines independently of protein kinase A. This intracellular phosphorylation of merlin directly correlates with in vitro assay of the autophosphorylation activity of Nef-activated PAK2. Importantly, merlin phosphorylation induced by Nef was also observed in human primary T cells. The finding that Nef induces phosphorylation of the key signaling molecule merlin suggests several possible roles for PAK2 activation in HIV pathogenesis. 相似文献
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.