Next issue: Methods and Advances in Biotech

The March 2008 issue of BTJ is again entirely devoted to Methods and Advances; featuring articles on: – BRET technology and application to screening assays – Using a commercial DNA extraction kit to obtain RNA for RT-PCR – Method of tracking nanogel particles in vivo and in vitro – RNA interference: An emerging generation of biologicals – Whole genome amplification using single primer PCR – Enzyme restriction and ligation-independent recombination expression vectors – Protoplast isolation and transient gene expression in switchgrass – Roust macroporous matrixes for cell immobilization – Hepatogenic differentiation of mesenchymal stem cells using microfluidic chips – A transformation procedure for the recalcitrant tomato – Bioreactor scale-up and oxygen transfer rate in microbial processes: An overview – Recent research of the genus Aspergillus for food and biotech applications Many of these exciting articles are already available online under “Early View”! A sneak preview of other content can be found under “News”. http://www.biotechnology-journal.com     

Next issue (July 2007): Biotech in Russia

Edited by Professor Michael Rabinovich, Moscow, Russia Highlight articles: Russia through the prism of the world biopharmaceutical market – Main trends of biosensor development in Russia – Novel Russian monoclonal antibody-based therapeutic agents – Genetic and molecular backgrounds for the novel sustainable agro-technologies – Russian safety assessment of plant GMOs – Biotechnological studies in the Far-Eastern Region of Russia – Preclinical immunological trials of candidate DNA vaccines for HIV – Russian DNA chips ... and much more: Read the next issue of BTJ!     

Next issue (November 2007): Singapore Biotech Crossroads

Edited by Dr. Michael Entzeroth, Singapore Highlight articles: – Singapore's biomedical sciences landscape – Re-starting malaria research at NITD – CombinatoRx moves its molecular speed-dating to Singapore – UK-Singapore relationships in life sciences – AMRI and Singapore: Driving discovery in Asia – Function of SIRT1 Deacetylase in Oncology – The chakragati mouse: rapid in vivo antipsychotic drug screening – Neuroscience drug discovery in Singapore ... and much more: Read the next issue of BTJ!     

Biotech Methods and Advances

Cover illustration: Biotech Methods and Advances. This BTJ special issue highlights articles on high-throughput protein production, a phage display method for fully in vitro recombinant antibody screening and a bioreactor setup to optimize biocatalysis. Image: Representative florescent micrograph depicting a living microdroplet of primary heart muscle cells containing therapeutic payloads for delivery through living cells, © Suwan Jayasinghe, London, UK.     

Methods and Advances in Biotech

Cover illustration: Methods and Advances in Biotech. Highlights in this issue are recombinant therapeutic proteins, HIV diagnosis and 3D imaging cytometry. Image: 3D distribution of chromatin inside living intact Hela cell, imaged during metaphase (p. 53). Montage by C. Machu and O. Renaud, Institut Pasteur, Paris. www.pfid.org/automation     

Methods and Advances in Biotech

Cover illustration: This special issue on “Methods and Advances in Biotech” consists mainly of technical reports on PCR-based methods, focussing on multiplexing PCR, single cell PCR, real-time PCR and other molecular biology methods. We also offer reviews on biomolecular computing, transgenesis in plants, and a method to discover tunnels in molecular structures. Picture DNA helix © David Martyn – FOTOLIA.     

Next issue (April 2008): Novel Approaches to Drug Discovery in Signal Transduction

Edited by Lodewijk Dekker, Nottingham, UK – Computational chemistry approaches – Cell-based assays for G-Protein-coupled Receptors – Cell-based label-free technologies Methods and Advances in Biotech – Application of proteomics in biotechnology – Mining marine biological wastes for bioactive molecules – PCR-based strategy to express endogenous protein levels in yeast – Method for tracking nanogel particles – Gene expression studies on bio-electrosprayed primary cardiac myocytes Many of these exciting articles are already available online under “Early View”! A sneak preview of other content can be found under “News”. http://www.biotechnology-journal.com     

Next issue (December 2007): Energy Production

Edited by Dr. Stefan Nordhoff, Marl, Germany Highlight articles: – Sustainable production of biofuels – Coupled production in biorefineries – Biodegradation of fuel oil hydrocarbons – Biobutanol: an attractive biofuel – Sustainable biobased energy, fuels and materials – Renewable resources in the chemical industry – breaking away from oil? – Using waste from olive oil industry for fuel production – Economic impacts of bio-refinery and resource cascading systems – Agricultural raw materials – energy or food? ... and much more: Read the next issue of BTJ!     

Next issue (May 2007): Brain-specific Diseases

Edited by Dr. Nektarios Tavernarakis, Heraklion, Greece Highlight articles: – Neuronal death vs neurogenesis after transient ischemia – C. elegans mitochondrial mutants to study human neurodegenerative diseases – Human huntingtin antibody epitope mapping – Amyotrophic lateral sclerosis – the tools of the trait – Biosensors for biogenic catecholamine detection – Comprehensive survey of p94/calpain 3 substrates by comparative proteomics – Molecular architecture of juxtaparanodal regions of myelinated fibers – Bio-electrosprays: A novel electrified jetting methodology for the safe handling and deployment of primary living organisms ... and much more: Read the next issue of BTJ!     

Next issue (March 2007): Textile biotechnology

Edited by Prof. Cavaco-Paolo (Lisbon, Portugal). Highlight articles: – Catalases for cleaner bleaching – Natural retting agents – Decolorization of reactive azo dyes – Wax removal for accelerated cotton scouring – Enzymatic cotton scouring products – Photochemical immobilization on polyethylene – Nitrilases for the surface modification of acrylic fibers – PET hydrolysis by Fusarium esterases – PVA-degrading enzymes in cotton fabric desizing ... and much more: Read the next issue of BTJ!     

Next issue (April 2007): Milk Processing

Edited by Prof. Knut Heller, Karlsruhe, Germany. Highlight articles: – Bacteriophages in dairy products: Pros and cons – Liberation of bioactive peptides from milk proteins – Lactobacillus delbrueckii subsp. bulgaricus for yoghurt with mild taste – Prebiotic galacto-oligosaccharides production using Lactobacillus reuteri – Lactobacillus kefiri biotransformation of pentoxifylline – Modification of milk proteins by microbial transglutaminase ... and much more: Read the next issue of BTJ!     

Next issue (June 2007): Molecular Recognition Technologies

Edited by Professor Alois Jungbauer, Vienna, Austria Highlight articles: – High-throughput protein purification under denaturating conditions – Efficient solubilization of inclusion bodies – Affinity precipitation an option for early capture in bioprocessing – IgG-Fc ligands derived from a soluble peptide library – Recombinant glycerol dehydratase from Klebsiella pneumoniae – In vivo glyco-engineered antibody with improved lytic potential – Plasmid adsorption to anion-exchange matrices – Biotransformation and chromatography ... and much more: Read the next issue of BTJ!     

Next issue (August 2007): Role of Kinases in Neuronal Function

Edited by Professor Marc Blondel, Brest, France Highlight articles: Role and regulation of Cdk5 in – neurofibrillary degeneration and neuronal death: the missing link to cell cycle reactivation – neuronal signaling, plasticity, and drug abuse – dendrite and synapse development – Cerebral ischemia, cell cycle elements ... and much more: Read the next issue of BTJ!     

Next issue: Mitochondria and ageing

The June 2008 issue of BTJ is devoted to Mitochondria and ageing. Featuring articles on: – Dietary restriction genes involved in energy metabolism – Structural implications of mitochondrial dynamics – Mitochondrial protein quality control: Implications in ageing – Age-related mitochondrial degenerative diseases in humans – The impact of mitochondrial DNA on human life span – Insulin-like growth factor induced signals activate mitochondrial respiration – Senescence factors in Podospora anserina independent of intrinsic senescence – Native-DIGE: A new look at the mitochondrial membrane proteome – Fusion and fission genes and the regulation of mitochondrial dynamics Many of these exciting articles are already available online under “Early View”! A sneak preview of other content can be found under “News”.     

2008年全球生物技术/转基因作物商业化发展态势——第一个十三年(1996-2008)

本文介绍了2008年转基因作物的主要情况.由于采用转基因作物取得了巨大经济、环境和社会效益,2008年(转基因作物商业化的第十三个年头),全世界上百万小型和资源匮乏型农户继续种植转基因作物,种植面积有了较大增长(图1).     

Next generation sequencing technology: Advances and applications

Impressive progress has been made in the field of Next Generation Sequencing (NGS). Through advancements in the fields of molecular biology and technical engineering, parallelization of the sequencing reaction has profoundly increased the total number of produced sequence reads per run. Current sequencing platforms allow for a previously unprecedented view into complex mixtures of RNA and DNA samples. NGS is currently evolving into a molecular microscope finding its way into virtually every fields of biomedical research. In this chapter we review the technical background of the different commercially available NGS platforms with respect to template generation and the sequencing reaction and take a small step towards what the upcoming NGS technologies will bring. We close with an overview of different implementations of NGS into biomedical research. This article is part of a Special Issue entitled: From Genome to Function.     

Next issue (October 2007): Multi-enzyme Systems for the Synthesis of Complex Natural Compounds

Edited by Dr. Stefan Martens, Marburg, Germany Highlight articles: – Flavonoids and other phenylpropanoid-derived natural products – Glucosylation of phenolic compounds using cultured plant cells – Ketocarotenoid biosynthesis in tobacco – Microbial production of natural raspberry ketone – A factorial approach to lactone production in yeast – Fermentative production of methylated stilbens – Biosynthesis of deoxyflavanones ... and much more: Read the next issue of BTJ!