A special report on India's biotech scenario: Advancement in biopharmaceutical and health care sectors

India's biotechnology industry has been growing towards new heights in conjunction with the recent economic outburst. The country has the potential to revolutionize biopharmaceutical and healthcare sectors. In this review, we have highlighted the achievements of India's biotechnology industry, especially biopharmaceutical and healthcare sectors that include therapeutics, diagnostics, stem cell research, human healthcare related bioinformatics and animal health care. We have also described regulatory mechanisms involved in India's health care biotech including manpower development.     

The biological sciences in India: Aiming high for the future

India is gearing up to become an international player in the life sciences, powered by its recent economic growth and a desire to add biotechnology to its portfolio. In this article, we present the history, current state, and projected future growth of biological research in India. To fulfill its aspirations, India''s greatest challenge will be in educating, recruiting, and supporting its next generation of scientists. Such challenges are faced by the US/Europe, but are particularly acute in developing countries that are racing to achieve scientific excellence, perhaps faster than their present educational and faculty support systems will allow.India, like China, has been riding a rising economic wave. At the time of writing this article, four Indians rank among the ten wealthiest individuals in the world, and the middle class is projected to rise to 40% of the population by 2025 (Farrell and Beinhocker, 2007). Even with the present global economic setbacks, India''s economy is expected to grow to become the third largest in the world. India''s recent economic boom has been driven largely by its service and information technology industries, fueled to a large extent by jobs provided by multinational companies. However, this “outsourcing” model is unlikely to persist indefinitely. India''s future must rely upon its own capacity for innovation, which will require considerable investment in education and research.Biotechnology represents a potential sector of economic growth and an important component in India''s national health agenda. Appreciating the important role that biology will play in this century, the Indian government is expanding as well as starting several new biological research institutes, which will open up many new positions for life science researchers. Funds also are becoming available for state-of-the-art equipment, thus decreasing the earlier large disparity in support facilities between the top research institutes in India and the US/Europe. India is becoming an increasingly viable location to conduct biological research and a fertile ground for new biotechnology companies. However, success need not rise in proportion to money invested, unless India attracts and supports its best young people to do research.Many academic centers and industries in the US/Europe are beginning to have an eye on India, the world''s largest democratic country, for possible collaborations. Western institutions have long benefited from having Indian scientists on their faculty or postdoctoral fellows/graduate students in their laboratories (perhaps benefitting more than India itself). However, Western scientists, by and large, know very little about the scientific and educational systems in India. (As was true of authors of this article before we began our 8-month sabbatical at the National Center for Biological Sciences in Bangalore). The goal of this article is to provide a brief historical and contemporary view of the biological sciences in India. We also provide an editorial perspective on the upcoming challenges for the Indian life sciences, with a particular emphasis on how India will grow and support its next generation of scientific leaders.     

Jural relations of middle‐class marriage and women as legal subjects in the imaginary of ‘new India’

In India's capital New Delhi, four Family Courts were set up between 2009 and 2012, and 12 mediation institutions known as Crime Against Women Cells (CAW cells) were established during the same period. The Indian state has also endorsed gender‐equalising family legislation, mutual‐consent divorce and introduced new language of and for mediation. Together with India's projection of a rising global economy, these recent legal changes have engendered perceptions of a dramatic upturn in formal divorce and of women as liberal legal subjects. In the anthropology of Asia, marital practices have crucially informed our comprehension of modernisation, family formations and moral panics. This article explores the impact of new forms of legal availability on marriage, family and kinship among the metropolitan middle classes. It ethnographically engages with important structural shifts reflected in the intimate lives of Hindu couples, but also foregrounds a cautious narrative of newly imagined jural relations.     

Entangled in the imagination: New middle-class apprehensions in an Indian theme park

By analysing a visit to Ramoji Film City, a theme park in Hyderabad, by a group of youths, this essay examines how transterritorial flows of imagery are socially contextualized by India's new middle classes. A theme park is a spatial arrangement thatincorporatesimaginary worlds and makes them available to experiencein a contextless ‘here-and-now’. As such, the theme parkis a stage where the fragileidentity of India's new middle classes is put on trial. Despite the appeal of the theme park for potential middle-class visitors, the visitors I followed appeared largely uninspired by the imagery of the far away and past in Film City, and they found it difficult to incorporate their visit to the theme park as a meaningful social practice. The case of Ramoji Film City shows how the social situatedness of the subject determines the significance of the imagination in the transnational world.     

There Once Was a Maiden and a Middle Class: The Making of a Neoliberal Thriller

Coinciding with India's turn to neoliberalism, a new genre—the conspiracy thriller—has appeared in popular Hindi cinema. Its aesthetics of speed, movement, and surprise express the fear and furious reasoning of an individual who must save her- or himself from a conspiracy that threatens to destroy them. This article contextualizes the genre in the urban spaces of neoliberalism, its architecture of private enclosures, and the paranoid subjectivities it has produced.     

Nationalism remixed? The politics of cultural flows between the South Asian diaspora and ‘homeland’

This article examines ‘Asian electronic music’, a generally progressive diasporic South Asian scene which fuses electronic dance music beats with instruments/sounds traditionally associated with the subcontinent, and how it became embedded into ‘majoritarian’ Indian nationalism. In India, the music's perceived ‘fusion’ aesthetic became emblematic of an emergent India which was economically prosperous while ‘respecting’ its cultural heritage. Using the case of an album which remixed India's national song, Vande Mataram, this article explores the convergences and divergences between Asian electronic musicians in Delhi and Hindu nationalists. The article concludes that the musicians in Delhi did not lend to Hindu nationalism. However, they perhaps gave secular Indian nationalism a ‘cool’ gloss. Ultimately, the production and consumption of Asian electronic music in Delhi raises significant questions regarding the scene's relationship to Indian nationalisms.     

Intimate Territories and the Experimental Subject in Ladakh,India

Abstract

This paper explores the management of reproduction and sexuality as experimental political practice. In Leh District of India's Jammu and Kashmir State, vote bloc politics and a tenuous geopolitical context highlight the reproductive body's potential to maintain political and territorial control through demographic trends. Conflict between the Buddhist majority and Muslim minority is articulated partly through the regulation of fertility and sexuality. Population is described as a zero-sum game in which each side acquires or cedes territory; activists and religious leaders experiment with the body as a territorial tool. These projects collide with the hopes and fears of women and men considering love, marriage, pregnancy, and contraceptive use. This paper draws on research conducted in 2004 and 2007–2009 to explore how women's desiring and reproductive bodies are folded into geopolitical experiments, how women cope under this experimental regime, and the ways that they turn to a tactic of ‘not knowing.’     

Violence,Victimhood and Trauma: Exploring the Partition Narratives of Bombay Cinema

This article focuses on a corpus of Hindi films that, from a variety of ideological and generic viewpoints, articulate Hindi cinema's presentation of India's Partition trauma. It asserts that the cinematic mediation of this trauma appears symptomatic of the vicissitudes of larger discourses at work, and can be categorized into three phases with definite trajectories; wherein Partition first appears as a “denial,” where the traumatic episode becomes a Barthesian absence in the immediate aftermath of the Partition. Later, Partition reappears as “supracommunal trauma” transcending established national boundaries or spheres of sectarian interest in deference to the national conciliation project of Nehruvian secularism. In its third trajectory of the Hindutva milieu, films like Gadar and Hey Ram mark the “expropriation” of the Partition narratives from collective consciousness of experiences into a purely sectarian phenomenon.     

‘Our bones are made of Iron’: the political ecology of Garhwali women's activism

In the Garhwal Himalaya of India's Uttarakhand State, a series of social movements emerged in the late 2000s to contest hydroelectric dams on a tributary of the sacred River Ganga. Within these opposition movements, men often took high‐profile leadership roles whereas women from a range of socio‐economic backgrounds formed the overwhelming base of participation at meetings, assemblies, and rallies. This article draws from event‐based participation and semi‐structured interviews to explore the diverse concerns that women gave to explain their engagements with opposition efforts. I counter essentialist frames and employ a feminist political ecology approach to argue that the gendered dynamics are attributable to historical, cultural, religious, and political‐economic influences. The article contributes to anthropologies of gender, environment, and social movements by taking an approach focused on disparities of practice and power that helps situate Garhwali women's roles in development contestations.     

Colonial Polyrhythm: Imaging Action in the Early 19th Century

This article proposes a new reading of early-19th-century modernity by examining India's so-called “ethnographic” paintings, and arguing that rather than participate in a trajectory of speed and acceleration these works produce colonial polyrhythmic temporality. First, the article establishes that many of these images depict action, not ethnicity or occupational group. It then situates these images in economies of circulation, viewing, politics and commercial enterprise. By focusing on the action in the subject matter—do-ing rather than do-er, processes rather than occupations—a layered, polyrhythmic range of temporalities emerges, upturning dualistic, acceleration-driven, and rupture-based understandings of visual culture from this period.     

The Overall Situation in the South China Sea in the New Millennium: Before and After the September 11 Terrorist Attacks

This contribution reviews the overall situation in the South China Sea (SCS) between 2000 and June 2002. A number of important new developments and policy events have occurred during this period, including: the expansion of India's military presence from the Indian Ocean into the SCS; the efforts taken by Japan to promote cooperation in the SCS to deal with maritime security issues; the increase of military exercises conducted by both the claimants and nonclaimants in the SCS; the improvement of diplomatic relationships among the claimants, in particular, between China and the member states of ASEAN; the election of George W. Bush as U.S. President; the EP-3 incident and the September 11 terrorist attacks. These developments and events have the potential to affect peace and stability in the SCS. The changing security configuration of the SCS and possible responses of the claimants to the new strategic framework after the September 11 terrorist attacks, as well as their implications for managing potential conflicts in the SCS, are discussed.­     

Non‐edible oil seed producing Calophyllum inophyllum ideal for India's future biofuel development

The impending climate change crisis has stimulated enormous interest in the development of biofuel globally. The supporters of biofuel hail that it is naturally carbon‐neutral whereas the critiques argue that the large‐scale plantations and production of biofuel based on Jatropha can not only strain agricultural resources but also threaten future food security. India's subsistence farmers are often faced with challenges and constraints of poverty. Foremost among the challenges are the marginal environmental conditions for agriculture often influenced by erratic rainfall, drought, poor soil quality, and unreliable irrigation water supply. In this article, we have presented a case study on the potential to use nonedible seeds from naturally occurring tree species, Calophyllum inophyllum to meet the increasing demand for biofuel production in India.     

Does environmental management improve enterprise's value? – An empirical research based on Chinese listed companies

The company's environmental management behaviors can improve the relationship between the company stakeholders, help companies to sustainably develop. But it is more seen as an obligation and cost of the company's environmental protection in developing countries. So what kind of impact the environmental protection have on the value of the company? Taking Chinese listing Corporation as a sample. This paper analyzes the impact of enterprises’ environmental management and its disclosure on corporate value. We conclude that environmental management excluding independent environment report can improve corporate value. In specific environmental management measures, producing environmental friendly products can help environmental friendly products gain recognition and improve corporate value significantly.     

A David and Goliath story: tobacco advertising and self-regulation in Australia.

A small group of health workers succeeded in getting the largest tobacco advertising campaign in Australia banned by testing a clause in the advertising industry''s voluntary code of self-regulation. The group complained about a series of cigarette advertisements that featured an Australian entertainer who was popular with the young. Though the tobacco company denied the entertainer''s major appeal to the young, the chairman of the Advertising Standards Council ruled that the campaign did breach the code. The delay before the complaint was adjudicated--18 months--contrasted with the speed with which a series of antismoking advertisements had been withdrawn after complaints by a tobacco company''s advertisers. MOP UP''s victory in this case contains several lessons for people interested in restricting the promotional activities of multinational tobacco companies.     

India–Madagascar vicariance explains cascade beetle biogeography

India and Madagascar drifted apart more than 80 Mya, yet few taxonomic groups currently found in these regions bear any signature of this split. When drifting in isolation, extensive volcanic activity covered almost half of India in lava flows, likely triggering widespread extinction on the island. Consequently, most of India's rich extant flora and fauna are considered to be the result of recent Cenozoic dispersal, and no lineages are conclusively a result of ancient vicariance. Many of Madagascar's lineages also stem from either Cenozoic diversification or dispersal events, with the latter being a result of the close proximity of the island with mainland Africa. In the present study, we focus on two remarkable lineages of cascade beetles in the genera Scoliopsis and Tritonus (Coleoptera, Hydrophilidae), respectively, dwelling in the mountains of south India and Sri Lanka, as well as in Madagascar. Based on a molecular phylogeny of the family Hydrophilidae dated with eight fossils, we show that these two lineages are sister taxa, and diverged when Madagascar and Greater India (India, Sri Lanka, Seychelles) separated, suggesting a pattern of Gondwanean vicariance. The results of the present study show that, despite geological upheaval, the present‐day fauna of India still retains traces of its Gondwanan past.     

Deciphering allelic variability and population structure in buckwheat: An analogy between the efficiency of ISSR and SSR markers

Food and nutritional security continue to be the issues of concern in developing countries like ours. Exploring the reservoir of high potential unexplored genetic resources could address the world’s food and nutritional insecurity. The availability of diverse data and the population structure of any crop germplasm is a valuable genetic resource for discovering genes that can help achieve food and nutritional stability. We used seven ISSR and seven SSR markers to investigate diversity among 63 buckwheat genotypes, including landraces from India''s northwestern Himalayas. Various parameters such as percent polymorphism, PIC, resolving power, and marker index was used to evaluate the inequitable efficacy of these markers. We foundthat both marker systems are effective in detecting polymorphism in buckwheat germplasm. Seven ISSRs produced 55 polymorphic bands, while seven SSRs produced 32bands. When compared to ISSRs, SSRs had a greater average PIC value (0.43) than that of (0.36). ISSRs, on the other hand, had a resolving power of (4.38) compared to (1.42) for SSRs. The hierarchical cluster analysis dendrogram divided genotypes into three major clusters. We found that both marker systems were equally accurate in grouping buckwheat genotypes according to their geographical origins. Using 7 ISSR and 7 SSR markers, the model-based STRUCTURE analysis established a population with two sub-populations that correspond to species-based groupings. Within the population, there was a high level of genetic diversity. These results have consequences for both buckwheat breeding and conservation efforts.Keyword: Buckwheat, SSR, ISSR, Genetic diversity, Population structure     

Spatial analysis of endemism to redefine conservation areas in Western Ghats (India)

A meaningful effort for the preservation of endemism would require a deep understanding of its related mechanisms and an accurate estimation of its spatial distribution. Here, we applied methods dedicated to species distribution modelling (SDM) to map an integrated index in India's Western Ghats biodiversity hotspot, the endemic tree richness, and to use it for recommendations of protected areas. We then rigorously compared SDM results with spatially explicit and multiscale comparison tools, among them the cutting-edge correlation map and profile (CMP) technique, to finally draw up an endemic richness map with improved accuracy.The endemic richness showed a sharply increasing southward gradient in the Western Ghats, mainly driven by the seasonality of the temperature and the precipitation's stability. This precise quantification of the tree endemism pattern in peninsular India helped in identifying vulnerable areas in terms of conservation of biodiversity as a whole. The Indian authorities recently used our recommendations to extend protected areas in the southern tip of the Indian peninsula to conserve this endemic richness. We believe that spatial analyses and multiscale comparison tools such as those presented here can help conservationists everywhere to better cope with the difficulties met in identifying zones for protected status.     

Religion,ethnicity and politics: Hindu and Muslim Indian immigrants in the United States

This article focuses on the political struggles between Hindu and Muslim Indian immigrant groups in the United States over the definition of "Indianness". Hindu Indian American organizations define India as a Hindu society and are strong supporters of the Hindu nationalist movement in India. Muslim Indian American organizations, on the other hand, view India as a multi-religious and multicultural society. They are striving to safeguard India's secularism and towards this end, have entered into coalitional relationships with lower caste groups. Both types of organizations are working to influence American and Indian politics in line with their respective interests, leading to an exacerbation of the conflict between the two immigrant groups. This article examines the reasons for this development and its implications, both for the development of an Indian American community in the United States and for religion and politics in India.     

Increasing Compliance with Mass Drug Administration Programs for Lymphatic Filariasis in India through Education and Lymphedema Management Programs

Background

Nearly 45% of people living at risk for lymphatic filariasis (LF) worldwide live in India. India has faced challenges obtaining the needed levels of compliance with its mass drug administration (MDA) program to interrupt LF transmission, which utilizes diethylcarbamazine (DEC) or DEC plus albendazole. Previously identified predictors of and barriers to compliance with the MDA program were used to refine a pre-MDA educational campaign. The objectives of this study were to assess the impact of these refinements and of a lymphedema morbidity management program on MDA compliance.

Methods/Principal Findings

A randomized, 30-cluster survey was performed in each of 3 areas: the community-based pre-MDA education plus community-based lymphedema management education (Com-MDA+LM) area, the community-based pre-MDA education (Com-MDA) area, and the Indian standard pre-MDA education (MDA-only) area. Compliance with the MDA program was 90.2% in Com-MDA+LM, 75.0% in Com-MDA, and 52.9% in the MDA-only areas (p<0.0001). Identified barriers to adherence included: 1) fear of side effects and 2) lack of recognition of one''s personal benefit from adherence. Multivariable predictors of adherence amenable to educational intervention were: 1) knowing about the MDA in advance of its occurrence, 2) knowing everyone is at risk for LF, 3) knowing that the MDA was for LF, and 4) knowing at least one component of the lymphedema management techniques taught in the lymphedema management program.

Conclusions/Significance

This study confirmed previously identified predictors of and barriers to compliance with India''s MDA program for LF. More importantly, it showed that targeting these predictors and barriers in a timely and clear pre-MDA educational campaign can increase compliance with MDA programs, and it demonstrated, for the first time, that lymphedema management programs may also increase compliance with MDA programs.