共查询到20条相似文献,搜索用时 328 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. 总被引:27,自引:13,他引:14
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M Mietus-Snyder F M Sladek G S Ginsburg C F Kuo J A Ladias J E Darnell Jr S K Karathanasis 《Molecular and cellular biology》1992,12(4):1708-1718
12.
13.
14.
15.
16.
17.
18.
The cyclin B2 component of MPF is a substrate for the c-mos(xe) proto-oncogene product 总被引:15,自引:0,他引:15
Previous studies from this laboratory have shown that purified MPF from Xenopus eggs contains cyclin B2 complexed with cdc2 kinase. The activation of MPF during oocyte maturation is known to require expression of the c-mos(xe) proto-oncogene. We show here that immunoprecipitates of either v-mos from Moloney murine sarcoma virus-transformed NIH 3T3 cells or c-mos from Xenopus eggs phosphorylate cyclin B2 in vitro. Phosphopeptide analysis reveals a pattern similar to that observed with cdc2 kinase. Moreover, ablation of c-mos(xe) from oocytes by antisense oligonucleotide injection reduces the rate of cyclin B2 phosphorylation in oocyte extracts by 40%. These results suggest that the mechanism of activation of MPF by c-mos(xe) involves phosphorylation of the cyclin component. 相似文献
19.
20.