The forces behind cell movement

Cell movement is a complex phenomenon primarily driven by the actin network beneath the cell membrane, and can be divided into three general components: protrusion of the leading edge of the cell, adhesion of the leading edge and deadhesion at the cell body and rear, and cytoskeletal contraction to pull the cell forward. Each of these steps is driven by physical forces generated by unique segments of the cytoskeleton. This review examines the specific physics underlying these phases of cell movement and the origins of the forces that drive locomotion.     

The action behind the words: embryonic stem cell research marches on

Talk of policy has dominated talk of science for those interested in embryonic stem cell science. But research is continuing, and the advances are making clear why embryonic stem cells are such an important scientific and medical resource.     

More than words: the chemistry behind the interactions in the plant holobiont

Plants and microbes have evolved sophisticated ways to communicate and coexist. The simplest interactions that occur in plant-associated habitats, i.e., those involved in disease detection, depend on the production of microbial pathogenic and virulence factors and the host's evolved immunological response. In contrast, microbes can also be beneficial for their host plants in a number of ways, including fighting pathogens and promoting plant growth. In order to clarify the mechanisms directly involved in these various plant–microbe interactions, we must still deepen our understanding of how these interkingdom communication systems, which are constantly modulated by resident microbial activity, are established and, most importantly, how their effects can span physically separated plant compartments. Efforts in this direction have revealed a complex and interconnected network of molecules and associated metabolic pathways that modulate plant–microbe and microbe–microbe communication pathways to regulate diverse ecological responses. Once sufficiently understood, these pathways will be biotechnologically exploitable, for example, in the use of beneficial microbes in sustainable agriculture. The aim of this review is to present the latest findings on the dazzlingly diverse arsenal of molecules that efficiently mediate specific microbe–microbe and microbe–plant communication pathways during plant development and on different plant organs.     

长江流域生态系统格局演变及驱动力

长江流域生态系统格局复杂,多种社会经济、政策和自然因素对土地利用变化的影响使得生态环境发生变化。分析了2000年至2015年长江流域生态系统格局和演变特征,及主要驱动力对生态系统变化的贡献。15年间,共有约6.4万km~2的生态系统类型发生变化,城镇增长67.5%,农田缩减7.5%,森林增加2.1%,剧烈的生态系统变化集中于下游,以及中上游的大城市,城镇聚集区以及退耕还林区。生态系统景观破碎化程度和景观多样性提高。上、中、下游生态系统格局、构成差异较大,15年间,上游和下游森林显著增加,下游城镇显著扩张、农田和湿地显著缩减,上游湿地增加最为显著。城镇化是生态系统格局演变的首要驱动力,对生态系统变化的贡献率达48.0%,长江下游城镇化的贡献率高达64.5%。生态保护与恢复工程是第二驱动力,对生态系统变化的贡献率为32.8%,在上游高达47.8%。水资源开发和农业开发贡献率分别为8.5%和9.9%,此外,气候变化促使高原湖泊面积增大。为保护长江流域生态系统的可持续发展,需划定生态保护红线,合理规划城市化进程中的土地利用,保护优质耕地,禁止重要湿地的开发。     

Molecular motors: the driving force behind mammalian left-right development

The molecular motors dynein and kinesin are large protein complexes that convert the energy generated by ATP hydrolysis into directional movement along the microtubule cytoskeleton. They are required for a myriad of cellular processes, including mitotic spindle movement, axonal and vesicular transport, and ciliary beating. Recently, it has been shown that, in addition, they have a unique role during embryonic patterning: they are required to orient and establish the left-right axis in early vertebrate development.     

The driving forces behind the impressive progression of the journal of cell communication and signaling (JCCS)

The recent increase of the Journal of Cell Signaling and Communication’ 2020 Impact Factor to 5.782, and its growing audience in the scientific community, provides an opportunity to step back and look at different aspects of this indicator’s value. The take home message is that the top-ten major contributions to the 2020 ranking originated from North America and Europe followed by India with a high percentage of CCN-related publications and an excellent proportion of Editorial Board members’ contributions to the Top10 best citations for the 2018–2019 period.     

A kinetic theory of diffusion forces in metabolizing systems

The development of a molecular theory of the diffusion drag forces in liquids is attempted by considering the liquids as limiting cases of very dense gases. An expression is derived for the force on a small particle suspended in a nonuniform mixture of such gases on the basis of kinetic theory. Another expression for the order of magnitude of the force on a larger particle is obtained by introducing certain hydrodynamical considerations. These results are compared with an expression previously derived by N. Rashevsky, and estimates are made of the order of magnitude of the volume force on the granules and particles within a typical cell due to the diffusion of metabolites. It is found that the drag forces, exerted by a diffusing solute, depend to a very large extent on the physical properties of the solvent.     

The pen and the sword: recovering the disciplinary identity of physiology and anatomy before 1800: I: Old physiology—the pen

It is argued that the disciplinary identity of anatomy and physiology before 1800 are unknown to us due to the subsequent creation, success and historiographical dominance of a different discipline—experimental physiology. The first of these two papers deals with the identity of physiology from its revival in the 1530s, and demonstrates that it was a theoretical, not an experimental, discipline, achieved with the mind and the pen, not the hand and the knife. The physiological work of Jean Fernel, Albrecht von Haller and others is explored to prove this point. In conclusion this old physiological tradition is compared to the new experimental physiology, as practised by François Magendie and Pierre Flourens.     

The surgical marking pen: a comparative study

A study has been undertaken to objectively evaluate the available surgical marking pens. Representative samples were requested from manufacturers of marking pens. Standardized skin preparations were utilized in accordance with the recommendation of the manufacturer of the skin-preparation substance (Betadine, pHisoHex, Hibiclens). Evaluation of the marking pens was done by the ability to make an easily discernible mark and maintain this ability over a 1-year storage interval. Objective evaluation demonstrated a marked variation in effectiveness of the marking pens. Consideration of skin-preparation solutions and types of marking pens are discussed.     

Mechanical forces shaping the development of the inner ear

The inner ear is one of the most complex structures in the mammalian body. Embedded within it are the hearing and balance sensory organs that contain arrays of hair cells that serve as sensors of sound and acceleration. Within the sensory organs, these hair cells are prototypically arranged in regular mosaic patterns. The development of such complex, yet precise, patterns require the coordination of differentiation, growth, and morphogenesis, both at the tissue and cellular scales. In recent years, there is accumulating evidence that mechanical forces at the tissue, the cellular, and the subcellular scales coordinate the development and organization of this remarkable organ. Here, we review recent works that reveal how such mechanical forces shape the inner ear, control its size, and establish regular cellular patterns. The insights learned from studying how mechanical forces drive the inner ear development are relevant for many other developmental systems in which precise cellular patterns are essential for their function.     

Joining forces: feedback and integration in plant development

Feedback and integration of information are of paramount importance for the robust functioning and dynamics of biological systems. In plant developmental biology, experimentation is increasingly combined with computational modeling to obtain a better understanding of how such regulatory interactions shape the systems' behavior. Here we highlight experimental and modeling studies on feedback loops and integration mechanisms involved in plant development. These studies have substantially expanded our understanding of previously characterized gene regulatory networks (GRNs). In addition, they illustrate the pervasiveness of regulatory interactions between seemingly unrelated processes and levels of organization. Modelers in plant development will increasingly face the challenges of what level of detail, which processes and how many levels of organization to incorporate when trying to understand a particular process.