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后基因组时代中的结构生物学 总被引:15,自引:1,他引:14
王大成 《生物化学与生物物理进展》2000,27(4):340-344
20 0 0年 6月 2 6日 ,美英两国首脑会同公私两大人基因组测序集团 ,在华盛顿白宫东厅正式向世人宣告 :人基因组的工作草图 (workingdraft)已经绘制完成 .以此为标志 ,在人类跨进 2 1世纪历史新纪元之际 ,生命科学也正在迎来一个崭新的时代 ,即后基因组时代 (post genomeera) .这是生命科学历史发展中一次新的飞跃 .2 0世纪生物学的最基本成就是揭示生命机体的世代遗传主要是以基因为载体的核酸负责 ,有机体的当代生命活动主要决定于蛋白质的结构与功能 ,从而将整个生物学推进到以核酸和蛋白质为中心的分子生物学时… 相似文献
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The increasing use of high-throughput technologies and computational modeling is revealing new levels of biological function and organization. How are these features of systems biology influencing our view of the cell? 相似文献
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Mire Convery Caitríona Dennis Sin Rowsell Andreas Engel J Bernard Heymann Gary Parkinson Rob Russell Gianfranco Gilardi Richard Newman Irmgard Sinning Sabine Flitsch Philip AS Lowden Steve Matthews Gerard J Kleywegt Jon D Stewart 《Current opinion in structural biology》1999,9(6):653
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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《Current opinion in structural biology》2001,11(5):501-510
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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《Current opinion in structural biology》2000,10(2):129-134
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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《Current opinion in structural biology》2000,10(3):265-271
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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《Current opinion in structural biology》2000,10(4):391-395
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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《Current opinion in structural biology》2001,11(3):263-270
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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Mire Convery Caitríona Dennis Sin Rowsell Tanja Kortemme Ora Schueler-Furman William J. Wedemeyer Andreas Engel Andras Fiser Gary Parkinson Richard Copley Gianfranco Gilardi Richard Newman Irmgard Sinning Sabine L. Flitsch Philip A. S. Lowden Airlie McCoy Tim Dafforn Jon D. Stewart 《Current opinion in structural biology》2001,11(6):645
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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《Current opinion in structural biology》2002,12(2):135-140
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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《Current opinion in structural biology》2000,10(1):1-9
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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Current and emerging technologies in reproductive biology, including assisted reproductive technologies and animal cloning, are discussed in the context of the impact of genomics era biology. The discussion focuses on the endocrinology associated with establishment and maintenance of pregnancy, fetal-placental development, lactation, and neonatal survival. Various aspects of uterine biology, including development during the neonatal period and function in adult females, are discussed with respect to reproductive efficiency. It is clear that combining strategies for use of conventional animal models for studying the reproductive system with new genomics technologies will provide exceptional opportunities in discovery research involving data integration and application of functional genomics to benefit animal agriculture and the biomedical community. New and emerging biotechnologies and comparative genomics approaches will greatly advance our understanding of genes that are critical to development of the reproductive system and to key events at each stage of the reproductive cycle of females and males. 相似文献
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Holmes KC 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》1999,354(1392):1977-1984
Protein crystallography has become a major technique for understanding cellular processes. This has come about through great advances in the technology of data collection and interpretation, particularly the use of synchrotron radiation. The ability to express eukaryotic genes in Escherichia coli is also important. Analysis of known structures shows that all proteins are built from about 1000 primeval folds. The collection of all primeval folds provides a basis for predicting structure from sequence. At present about 450 are known. Of the presently sequenced genomes only a fraction can be related to known proteins on the basis of sequence alone. Attempts are being made to determine all (or as many as possible) of the structures from some bacterial genomes in the expectation that structure will point to function more reliably than does sequence. Membrane proteins present a special problem. The next 20 years may see the experimental determination of another 40,000 protein structures. This will make considerable demands on synchrotron sources and will require many more biochemists than are currently available. The availability of massive structure databases will alter the way biochemistry is done. 相似文献
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Mire Convery Vanita D. Sood Tanja Kortemme Andras Fiser Gary Parkinson Richard Copley Gianfranco Gilardi Richard Newman Irmgard Sinning Airlie McCoy Tim Dafforn Adriana E. Miele Jon D. Stewart 《Current opinion in structural biology》2002,12(6):685
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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《Current opinion in structural biology》2002,12(1):1-8
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献
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《Current opinion in structural biology》2001,11(2):131-138
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in structural biology. 相似文献