15th International Cancer Congress

Meeting announcement

15th International Cancer Congress     

13th International Congress of Biochemistry

Cytochrome caa₃ (cytochrome oxidase) from the thermophilic bacterium PS3 can exhibit full catalytic activity in the presence of ascorbate and TMPD or other electron donors and in the absence of added soluble c-type cytochromes. It appears to possess only a low-affinity and not a high-affinity site for the soluble cytochromes. Proteoliposomal cytochrome caa₃ develops an effective membrane potential in the presence of ascorbate and TMPD or PMS, in the absence of added soluble cytochrome c. Reduction of the a₃ centre is blocked in the presence of cyanide. During reductive titrations of the cyanide-inhibited enzyme, electrons initially equilibrate among three centres, the c haem, the a haem and one of the associated Cu atoms. During steady-state turnover, electrons probably enter the complex via the bound c haem; the a haem and perhaps an associated Cu_A atom are reduced next. It is concluded that, despite its size and hydrophobic association with the aa₃ complex, the haem c-containing subunit can behave in an analogous way to that of mammalian cytochrome c, bound at the high-affinity site of the eucaryotic enzyme.     

遗传学领域的"抽样调查"--第18届国际遗传学大会侧记

第１８届遗传学大会于１９９８年８月１０日至１５日在北京举行。这不仅是在本世纪末对遗传学研究成果进行的最后一次回顾,也是对迎接新世纪的遗传学研究队伍的第一次检阅。这次会议聚集了５４个国家和地区近２０００位科研人员,其中１３５３人提交了论文摘要８２８人出...