共查询到20条相似文献,搜索用时 31 毫秒
1.
Körtvélyes J Bankó EM Andics A Rudas G Németh J Hermann P Vidnyánszky Z 《Acta biologica Hungarica》2012,63(Z1):65-79
Amblyopia is a visual disorder caused by an anomalous early visual experience. It has been suggested that suppression of the visual input from the weaker eye might be a primary underlying mechanism of the amblyopic syndrome. However, it is still an unresolved question to what extent neural responses to the visual information coming from the amblyopic eye are suppressed during binocular viewing. To address this question we measured event-related potentials (ERP) to foveal face stimuli in amblyopic patients, both in monocular and binocular viewing conditions. The results revealed no difference in the amplitude and latency of early components of the ERP responses between the binocular and fellow eye stimulation. On the other hand, early ERP components were reduced and delayed in the case of monocular stimulation of the amblyopic eye as compared to the fellow eye stimulation or to binocular viewing. The magnitude of the amblyopic effect measured on the ERP amplitudes was comparable to that found on the fMRI responses in the fusiform face area using the same face stimuli and task conditions. Our findings showing that the amblyopic effects present on the early ERP components in the case of monocular stimulation are not manifested in the ERP responses during binocular viewing suggest that input from the amblyopic eye is completely suppressed already at the earliest stages of visual cortical processing when stimuli are viewed by both eyes. 相似文献
2.
在用事件相关电位(event-related potentials,ERP)研究视觉空间注意问题时,直接观察ERP数据就可得出,空间注意的主要作用是对视觉信息处理的调制,它出现在刺激开始后大约80~250ms,主要表现为枕叶的P1、N1和P2波有明显的增强但它们的潜伏期没有变化。采用基于协同学的时空模式分解方法,把视觉空间注意ERP分解为3个模式成分。结果表明,注意不仅使模式1的第一个正波成分(P11)、第一个负波成分(N11)以及第二个正波成分(P12)增强,还使模式3的第一个正波成分(P31)的潜伏期缩短。用探照灯模型对这些现象作了初步解释,说明该方法是研究注意ERP的一种有潜力的新方法。 相似文献
3.
Repeated visual processing of an unfamiliar face suppresses neural activity in face-specific areas of the occipito-temporal cortex. This "repetition suppression" (RS) is a primitive mechanism involved in learning of unfamiliar faces, which can be detected through amplitude reduction of the N170 event-related potential (ERP). The dorsolateral prefrontal cortex (DLPFC) exerts top-down influence on early visual processing. However, its contribution to N170 RS and learning of unfamiliar faces remains unclear. Transcranial direct current stimulation (tDCS) transiently increases or decreases cortical excitability, as a function of polarity. We hypothesized that DLPFC excitability modulation by tDCS would cause polarity-dependent modulations of N170 RS during encoding of unfamiliar faces. tDCS-induced N170 RS enhancement would improve long-term recognition reaction time (RT) and/or accuracy rates, whereas N170 RS impairment would compromise recognition ability. Participants underwent three tDCS conditions in random order at ∼72 hour intervals: right anodal/left cathodal, right cathodal/left anodal and sham. Immediately following tDCS conditions, an EEG was recorded during encoding of unfamiliar faces for assessment of P100 and N170 visual ERPs. The P3a component was analyzed to detect prefrontal function modulation. Recognition tasks were administered ∼72 hours following encoding. Results indicate the right anodal/left cathodal condition facilitated N170 RS and induced larger P3a amplitudes, leading to faster recognition RT. Conversely, the right cathodal/left anodal condition caused N170 amplitude and RTs to increase, and a delay in P3a latency. These data demonstrate that DLPFC excitability modulation can influence early visual encoding of unfamiliar faces, highlighting the importance of DLPFC in basic learning mechanisms. 相似文献
4.
Many studies have linked the processing of different object categories to specific event-related potentials (ERPs) such as the face-specific N170. Despite reports showing that object-related ERPs are influenced by visual stimulus features, there is consensus that these components primarily reflect categorical aspects of the stimuli. Here, we re-investigated this idea by systematically measuring the effects of visual feature manipulations on ERP responses elicited by both structure-from-motion (SFM)-defined and luminance-defined object stimuli. SFM objects elicited a novel component at 200-250 ms (N250) over parietal and posterior temporal sites. We found, however, that the N250 amplitude was unaffected by restructuring SFM stimuli into meaningless objects based on identical visual cues. This suggests that this N250 peak was not uniquely linked to categorical aspects of the objects, but is strongly determined by visual stimulus features. We provide strong support for this hypothesis by parametrically manipulating the depth range of both SFM- and luminance-defined object stimuli and showing that the N250 evoked by SFM stimuli as well as the well-known N170 to static faces were sensitive to this manipulation. Importantly, this effect could not be attributed to compromised object categorization in low depth stimuli, confirming a strong impact of visual stimulus features on object-related ERP signals. As ERP components linked with visual categorical object perception are likely determined by multiple stimulus features, this creates an interesting inverse problem when deriving specific perceptual processes from variations in ERP components. 相似文献
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6.
Adult subjects were asked to recognize a hierarchical visual stimulus (a letter) while their attention was drawn to either the global or local level of the stimulus. Event-related potentials (ERP) and psychophysical indices (reaction time and percentage of correct responses) were measured. An analysis of psychophysical indices showed the global level precedence effect, i.e., the increase in a small letter recognition time when this letter is a part of incongruent stimulus. An analysis of ERP components showed level-related (global vs. local) differences in the timing and topography of the brain organization of perceptual processing and regulatory mechanisms of attention. Visual recognition at the local level was accompanied by (1) stronger activation of the visual associative areas (Pz and T6) at the stage of sensory features analysis (P1 ERP component), (2) involvement mainly of inferior temporal cortices of the right hemisphere (T6) at the stage of sensory categorization (P2 ERP component), and (3) involvement of prefrontal cortex of the right hemisphere at the stage of the selection of the relevant features of the target (N2 ERP component). Visual recognition at the global level was accompanied by (1) pronounced involvement of mechanisms of early sensory selection (N1 ERP component), (2) prevailing activation of parietal cortex of the right hemisphere (P4) at the stage of sensory categorization (P2 ERP component) as well as at the stage of the target stimulus identification (P3 ERP component). It is suggested that perception at the global level of the hierarchical stimulus is related primarily to the analysis of the spatial features of the stimulus in the dorsal visual system whereas the perception at the local level primarily involves an analysis of the object-related features in the ventral visual system. 相似文献
7.
Agustin Ibanez Hugo Urquina Agustín Petroni Sandra Baez Vladimir Lopez Micaela do Nascimento Eduar Herrera Raphael Guex Esteban Hurtado Alejandro Blenkmann Leandro Beltrachini Carlos Gelormini Mariano Sigman Alicia Lischinsky Teresa Torralva Fernando Torrente Marcelo Cetkovich Facundo Manes 《PloS one》2012,7(10)
Background
Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing.Methodology/Principal Findings
We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind).Conclusions/Significance
This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments. 相似文献8.
Change blindness refers to the inability to detect visual changes if introduced together with an eye-movement, blink, flash of light, or with distracting stimuli. Evidence of implicit detection of changed visual features during change blindness has been reported in a number of studies using both behavioral and neurophysiological measurements. However, it is not known whether implicit detection occurs only at the level of single features or whether complex organizations of features can be implicitly detected as well. We tested this in adult humans using intact and scrambled versions of schematic faces as stimuli in a change blindness paradigm while recording event-related potentials (ERPs). An enlargement of the face-sensitive N170 ERP component was observed at the right temporal electrode site to changes from scrambled to intact faces, even if the participants were not consciously able to report such changes (change blindness). Similarly, the disintegration of an intact face to scrambled features resulted in attenuated N170 responses during change blindness. Other ERP deflections were modulated by changes, but unlike the N170 component, they were indifferent to the direction of the change. The bidirectional modulation of the N170 component during change blindness suggests that implicit change detection can also occur at the level of complex features in the case of facial stimuli. 相似文献
9.
Adult subjects were asked to recognize a hierarchical visual stimulus (a letter) while their attention was drawn to either
the global or local level of the stimulus. Event-related potentials (ERP) and behavioral indices (reaction time and percentage
of correct responses) were measured. An analysis of behavioral indices showed the global level precedence effect, i.e. the
increase in a small letter recognition time when this letter is a part of incongruent stimulus. An analysis of ERP components
showed level-related (global vs. local) differences in the timing and topography of the brain organization of perceptual processing
and regulatory mechanisms of attention. Visual recognition at the local level was accompanied by (1) stronger activation of
the visual associative areas (P
z
and T
6) at the stage of sensory features analysis (P1 ERP component), (2) involvement mainly of inferior temporal cortices of the
right hemisphere (T
6) at the stage of sensory categorization (P2 ERP component), and (3) involvement of prefrontal cortex of the right hemisphere
at the stage of selection of the relevant features of the target (N2 ERP component). Visual recognition at the global level
was accompanied by (1) pronounced involvement of mechanisms of early sensory selection (N1 ERP component), (2) prevailing
activation of parietal cortex of the right hemisphere (P
4) at the stage of sensory categorization (P2 ERP component) as well as at the stage of the target stimulus identification
(P3 ERP component). We suggested that perception of the hierarchical stimulus at the global level is related primarily to
the analysis of its spatial features in the dorsal visual system whereas the perception at the local level primarily involves
an analysis of the object-related features in the ventral visual system. 相似文献
10.
11.
S Makeig M Westerfield J Townsend T P Jung E Courchesne T J Sejnowski 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》1999,354(1387):1135-1144
Spatial visual attention modulates the first negative-going deflection in the human averaged event-related potential (ERP) in response to visual target and non-target stimuli (the N1 complex). Here we demonstrate a decomposition of N1 into functionally independent subcomponents with functionally distinct relations to task and stimulus conditions. ERPs were collected from 20 subjects in response to visual target and non-target stimuli presented at five attended and non-attended screen locations. Independent component analysis, a new method for blind source separation, was trained simultaneously on 500 ms grand average responses from all 25 stimulus-attention conditions and decomposed the non-target N1 complexes into five spatially fixed, temporally independent and physiologically plausible components. Activity of an early, laterally symmetrical component pair (N1aR and N1aL) was evoked by the left and right visual field stimuli, respectively. Component N1aR peaked ca. 9 ms earlier than N1aL. Central stimuli evoked both components with the same peak latency difference, producing a bilateral scalp distribution. The amplitudes of these components were no reliably augmented by spatial attention. Stimuli in the right visual field evoked activity in a spatio-temporally overlapping bilateral component (N1b) that peaked at ca. 180 ms and was strongly enhanced by attention. Stimuli presented at unattended locations evoked a fourth component (P2a) peaking near 240 ms. A fifth component (P3f) was evoked only by targets presented in either visual field. The distinct response patterns of these components across the array of stimulus and attention conditions suggest that they reflect activity in functionally independent brain systems involved in processing attended and unattended visuospatial events. 相似文献
12.
In children of 7-8 and 9-10 years old, the ERP components were studied by comparing two non-verbalized visuo-spatial stimuli shown in succession with 1.5-1.8 s interstimulus interval. We found the age-related differences in the specific way (and the extent to which) the cortical areas were involved into the processes of the reference stimulus (the first stimulus in the pair) encoding and into the process of comparing the memory trace against the test stimulus. In both age groups, the sensory-specific N1 ERP component in the visual cortices had larger amplitude during working memory than during free observation. Age-related differences in the processing of the sensory-specific parameters of a stimulus are most pronounced in ERP to the test stimulus: in children of 9-10, the amplitude of N1 component increased significantly in all caudal leads following the earlier increase in P1 component in the inferior temporal and occipital areas. In the children of that age, unlike children of 7-8, the early involvement of ventro-lateral prefrontal cortex becomes apparent. In that area an increase of positivity confined to 100-200 ms post-stimulus is observed. Substantial inter-group differences are observed in the late ERP components that are related to cognitive operations. In children of 7-8, presenting both reference and test stimuli causes a significant increase in the amplitude of late positive complex (LPC) in caudal leads with maximal increase being observed in parietal areas at 300-800 ms post-stimulus. In children of 9-10, one can see some adult-like features of the late ERP components during different stages of the working memory process: in fronto-central areas N400 component increases in response to the reference stimulus, whereas LPC increases in response to the test stimulus. The data reported in this work show that the almost mature functional organization of working memory is already in place at the age of 9-10. However, the extent of the prefrontal cortex (especially its dorsal areas) involvement does not yet match the level of maturity. 相似文献
13.
Tiantian Liu Shoukuan Mu Huamin He Lingcong Zhang Cong Fan Jie Ren Mingming Zhang Weiqi He Wenbo Luo 《Cognitive neurodynamics》2016,10(6):535-541
The N170 component is considered a neural marker of face-sensitive processing. In the present study, the face-sensitive N170 component of event-related potentials (ERPs) was investigated with a modified oddball paradigm using a natural face (the standard stimulus), human- and animal-like makeup stimuli, scrambled control images that mixed human- and animal-like makeup pieces, and a grey control image. Nineteen participants were instructed to respond within 1000 ms by pressing the ‘F’ or ‘J’ key in response to the standard or deviant stimuli, respectively. We simultaneously recorded ERPs, response accuracy, and reaction times. The behavioral results showed that the main effect of stimulus type was significant for reaction time, whereas there were no significant differences in response accuracies among stimulus types. In relation to the ERPs, N170 amplitudes elicited by human-like makeup stimuli, animal-like makeup stimuli, scrambled control images, and a grey control image progressively decreased. A right hemisphere advantage was observed in the N170 amplitudes for human-like makeup stimuli, animal-like makeup stimuli, and scrambled control images but not for grey control image. These results indicate that the N170 component is sensitive to face-like stimuli and reflect configural processing in face recognition. 相似文献
14.
Tobimatsu S Goto Y Yamasaki T Tsurusawa R Taniwaki T 《Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science》2004,23(6):273-276
The neural mechanisms for the perception of face and motion were studied using psychophysical threshold measurements, event-related potentials (ERPs), and functional magnetic resonance imaging (fMRI). A face-specific ERP component, N170, was recorded over the posterior temporal cortex. Removal of the high-spatial-frequency components of the face altered the perception of familiar faces significantly, and familiarity can facilitate the cortico-cortical processing of facial perceptions. Similarly, the high-spatial-frequency components of the face seemed to be crucial for the recognition of facial expressions. Aging and visuospatial impairments affected motion perception significantly. Two distinct components of motion ERPs, N170 and P200, were recorded over the parietal region. The former was related to horizontal motion perception while the latter reflected the perception of radial optic flow motion. The results of fMRI showed that horizontal movements of objects and radial optic flow motion were perceived differently in the V5/MT and superior parietal lobe. We conclude that an integrated approach can provide useful information on spatial and temporal processing of face and motion non-invasively. 相似文献
15.
Disruptions of natural texture appearance are known to negatively impact performance in texture discrimination tasks, for example, such that contrast-negated textures, synthetic textures, and textures depicting abstract art are processed less efficiently than natural textures. Presently, we examined how visual ERP responses (the P1 and the N1 in particular) were affected by violations of natural texture appearance. We presented participants with images depicting either natural textures or synthetic textures made from the original stimuli. Both stimulus types were additionally rendered either in positive or negative contrast. These appearance manipulations (negation and texture synthesis) preserve a range of low-level features, but also disrupt higher-order aspects of texture appearance. We recorded continuous EEG while participants completed a same/different image discrimination task using these images and measured both the P1 and N1 components over occipital recording sites. While the P1 exhibited no sensitivity to either contrast polarity or real/synthetic appearance, the N1 was sensitive to both deviations from natural appearance. Polarity reversal and synthetic appearance affected the N1 latency differently, however, suggesting a differential impact on processing. Our results suggest that stages of visual processing indexed by the P1 and N1 are sensitive to high-order statistical regularities in natural textures and also suggest that distinct violations of natural appearance impact neural responses differently. 相似文献
16.
Estate Sokhadze Joshua Baruth Allan Tasman Mehreen Mansoor Rajesh Ramaswamy Lonnie Sears Grace Mathai Ayman El-Baz Manuel F. Casanova 《Applied psychophysiology and biofeedback》2010,35(2):147-161
In our previous study on individuals with autism spectrum disorder (ASD) (Sokhadze et al., Appl Psychophysiol Biofeedback
34:37–51, 2009a) we reported abnormalities in the attention-orienting frontal event-related potentials (ERP) and the sustained-attention
centro-parietal ERPs in a visual oddball experiment. These results suggest that individuals with autism over-process information
needed for the successful differentiation of target and novel stimuli. In the present study we examine the effects of low-frequency,
repetitive Transcranial Magnetic Stimulation (rTMS) on novelty processing as well as behavior and social functioning in 13
individuals with ASD. Our hypothesis was that low-frequency rTMS application to dorsolateral prefrontal cortex (DLFPC) would
result in an alteration of the cortical excitatory/inhibitory balance through the activation of inhibitory GABAergic double
bouquet interneurons. We expected to find post-TMS differences in amplitude and latency of early and late ERP components.
The results of our current study validate the use of low-frequency rTMS as a modulatory tool that altered the disrupted ratio
of cortical excitation to inhibition in autism. After rTMS the parieto-occipital P50 amplitude decreased to novel distracters
but not to targets; also the amplitude and latency to targets increased for the frontal P50 while decreasing to non-target
stimuli. Low-frequency rTMS minimized early cortical responses to irrelevant stimuli and increased responses to relevant stimuli.
Improved selectivity in early cortical responses lead to better stimulus differentiation at later-stage responses as was made
evident by our P3b and P3a component findings. These results indicate a significant change in early, middle-latency and late
ERP components at the frontal, centro-parietal, and parieto-occipital regions of interest in response to target and distracter
stimuli as a result of rTMS treatment. Overall, our preliminary results show that rTMS may prove to be an important research
tool or treatment modality in addressing the stimulus hypersensitivity characteristic of autism spectrum disorders. 相似文献
17.
The current study examined the time course of implicit processing of distinct facial features and the associate event-related potential (ERP) components. To this end, we used a masked priming paradigm to investigate implicit processing of the eyes and mouth in upright and inverted faces, using a prime duration of 33 ms. Two types of prime-target pairs were used: 1. congruent (e.g., open eyes only in both prime and target or open mouth only in both prime and target); 2. incongruent (e.g., open mouth only in prime and open eyes only in target or open eyes only in prime and open mouth only in target). The identity of the faces changed between prime and target. Participants pressed a button when the target face had the eyes open and another button when the target face had the mouth open. The behavioral results showed faster RTs for the eyes in upright faces than the eyes in inverted faces, the mouth in upright and inverted faces. Moreover they also revealed a congruent priming effect for the mouth in upright faces. The ERP findings showed a face orientation effect across all ERP components studied (P1, N1, N170, P2, N2, P3) starting at about 80 ms, and a congruency/priming effect on late components (P2, N2, P3), starting at about 150 ms. Crucially, the results showed that the orientation effect was driven by the eye region (N170, P2) and that the congruency effect started earlier (P2) for the eyes than for the mouth (N2). These findings mark the time course of the processing of internal facial features and provide further evidence that the eyes are automatically processed and that they are very salient facial features that strongly affect the amplitude, latency, and distribution of neural responses to faces. 相似文献
18.
Individuals with profound deafness rely critically on vision to interact with their environment. Improvement of visual performance as a consequence of auditory deprivation is assumed to result from cross-modal changes occurring in late stages of visual processing. Here we measured reaction times and event-related potentials (ERPs) in profoundly deaf adults and hearing controls during a speeded visual detection task, to assess to what extent the enhanced reactivity of deaf individuals could reflect plastic changes in the early cortical processing of the stimulus. We found that deaf subjects were faster than hearing controls at detecting the visual targets, regardless of their location in the visual field (peripheral or peri-foveal). This behavioural facilitation was associated with ERP changes starting from the first detectable response in the striate cortex (C1 component) at about 80 ms after stimulus onset, and in the P1 complex (100-150 ms). In addition, we found that P1 peak amplitudes predicted the response times in deaf subjects, whereas in hearing individuals visual reactivity and ERP amplitudes correlated only at later stages of processing. These findings show that long-term auditory deprivation can profoundly alter visual processing from the earliest cortical stages. Furthermore, our results provide the first evidence of a co-variation between modified brain activity (cortical plasticity) and behavioural enhancement in this sensory-deprived population. 相似文献
19.
Studies of event-related potential (ERP) in the human brain have shown that the N170 component can reliably distinguish among different object categories. However, it is unclear whether this is true for different identifiable levels within a single category. In the present study, we used ERP recording to examine the neural response to different identification levels and orientations (upright vs. inverted) of Chinese characters. The results showed that P1, N170, and P250 were modulated by different identification levels of Chinese characters. Moreover, time frequency analysis showed similar results, indicating that identification levels were associated with object recognition, particularly during processing of a single categorical stimulus. 相似文献
20.
Higher N170 amplitudes to words and to faces were recently reported for faster readers of German. Since the shallow German orthography allows phonological recoding of single letters, the reported speed advantages might have their origin in especially well-developed visual processing skills of faster readers. In contrast to German, adult readers of Hebrew are forced to process letter chunks up to whole words. This dependence on more complex visual processing might have created ceiling effects for this skill. Therefore, the current study examined whether also in the deep Hebrew orthography visual processing skills as reflected by N170 amplitudes explain reading speed differences. Forty university students, native speakers of Hebrew without reading impairments, accomplished a lexical decision task (i.e., deciding whether a visually presented stimulus represents a real or a pseudo word) and a face decision task (i.e., deciding whether a face was presented complete or with missing facial features) while their electroencephalogram was recorded from 64 scalp positions. In both tasks stronger event related potentials (ERPs) were observed for faster readers in time windows at about 200 ms. Unlike in previous studies, ERP waveforms in relevant time windows did not correspond to N170 scalp topographies. The results support the notion of visual processing ability as an orthography independent marker of reading proficiency, which advances our understanding about regular and impaired reading development. 相似文献