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1.
心肌梗塞的肤纹学研究 总被引:2,自引:2,他引:0
本文报道了230例心肌梗塞病人和237名对照的肤纹学研究结果。手指嵴线计数、指端花纹频率、左手主线A桡侧终点频率和左手大鱼际花纹频率在病人与对照之间差别的显著。172个病人家庭和156个对照家庭手指嵴线计数复合分离分析结果表明,手指总嵴线计数与心肌梗塞的联系可能取决于病人胚胎期环境因素的影响。 相似文献
2.
Evelien Schurgers Martijn Moorlag Coenraad Hemker Theo Lindhout Hilde Kelchtermans Bas de Laat 《PloS one》2016,11(2)
To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemostasis and thrombosis, as the hemostatic system proved to be similar to that in man. Their small size however, has been a hurdle for more widespread use in hemostasis related research. In this study we developed a method that enables the measurement of thrombin generation in a single drop of non-anticoagulated zebrafish blood. Pre-treatment of the fish with inhibitors of FXa and thrombin, resulted in a dose dependent diminishing of thrombin generation, demonstrating the validity of the assay. In order to establish the relationship between whole blood thrombin generation and fibrin formation, we visualized the resulting fibrin network by scanning electron microscopy. Taken together, in this study we developed a fast and reliable method to measure thrombin generation in whole blood collected from a single zebrafish. Given the similarities between coagulation pathways of zebrafish and mammals, zebrafish may be an ideal animal model to determine the effect of novel therapeutics on thrombin generation. Additionally, because of the ease with which gene functions can be silenced, zebrafish may serve as a model organism for mechanistical research in thrombosis and hemostasis. 相似文献
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R. A. Murray Scott 《BMJ (Clinical research ed.)》1953,1(4821):1223-1224
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M. Toohey 《BMJ (Clinical research ed.)》1958,1(5065):252-255
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L. Poller 《BMJ (Clinical research ed.)》1969,1(5643):572-573
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A computational model of blood coagulation is presented with particular emphasis on the regulatory effects of blood flow, spatial distribution of tissue factor (TF), and the importance of the thrombomodulin-activated protein C inhibitory pathway. We define an effective prothrombotic zone that extends well beyond the dimensions of injury. The size of this zone is dependent on the concentrations of all reactive species, the dimensions of TF expression, the densities of surface molecules, and the characteristics of the flow field. In the case of tandem sites of TF, the relationship between the magnitude of the effective prothrombotic zone and the interval distance between TF sites dictate the net response of the system. Multiple TF sites, which individually failed to activate the coagulation pathway, are shown to interact in an additive manner to yield a prothrombotic system. Furthermore, activation of the thrombomodulin-activated protein C pathway in the regions between sites of TF downregulate the thrombin response at subsequent TF sites. The implications of prothrombotic effects, which extend downstream beyond the discrete site of injury to interact with subsequent lesions are critical given the systemic nature of atherosclerotic disease. 相似文献
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R. L. Richards 《BMJ (Clinical research ed.)》1962,1(5281):820-824
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Roeinton B. Khambatta 《BMJ (Clinical research ed.)》1953,1(4814):808-811
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A mathematical model is constructed to study thrombin production in human ovarian follicular fluid. The model results show
that the amount of thrombin that can be produced in ovarian follicular fluid is much lower than that in blood plasma, failing
to reach the level required for fibrin formation, and thereby supporting the hypothesis that in follicular fluid thrombin
functions to initiate cellular activities via intracellular signalling receptors. It is also concluded that the absence of
the amplification pathway to thrombin production in follicular fluid is a major factor in restricting the amount of thrombin
that can be produced. Titration of the initial concentrations of the various reactants in the model lead to predictions for
the amount of tissue factor and phospholipid that is required to maintain thrombin production in the follicle, as well as
to the conclusion that tissue factor pathway inhibitor has little effect on the time that thrombin generation is sustained.
Numerical experiments to determine the effect of factor V, which is at a much reduced level in follicular fluid compared to
plasma, and thrombomodulin, illustrate the importance for further experimental work to determine values for several parameters
that have yet to be reported in the literature. 相似文献
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Richard Waldram 《BMJ (Clinical research ed.)》1970,4(5734):559-560
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J. R. O'Brien 《BMJ (Clinical research ed.)》1974,2(5909):52-53
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Wm. L. Hooper 《BMJ (Clinical research ed.)》1960,2(5215):1805-1806
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