DNA-PKcs promotes fork reversal and chemoresistance

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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

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ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

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RADX prevents genome instability by confining replication fork reversal to stalled forks

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Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells

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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

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Double-stranded DNA binding function of RAD51 in DNA protection and its regulation by BRCA2

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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

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POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps

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The human pre-replication complex is an open complex

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Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

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RAD51 protects human cells from transcription-replication conflicts

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DCAF14 promotes stalled fork stability to maintain genome integrity

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An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication

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Homology-directed repair protects the replicating genome from metabolic assaults

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Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse

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CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis

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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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A replication fork determinant for the establishment of sister chromatid cohesion

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