DNA-PKcs promotes fork reversal and chemoresistance

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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

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Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells

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Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells

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REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

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53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

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A human breast atlas integrating single-cell proteomics and transcriptomics

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ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

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Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

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Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein

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SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation

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DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1

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Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

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Double-stranded DNA binding function of RAD51 in DNA protection and its regulation by BRCA2

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RADX prevents genome instability by confining replication fork reversal to stalled forks

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Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

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Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

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Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

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PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1

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