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Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice
Elizângela Beneval Bento Francisco Elizaudo de Brito Júnior Dayanne Rakelly de Oliveira Cícera Norma Fernandes Gyllyandeson de Araújo Delmondes Francisco Rafael Alves Santana Cesário Cristina Kelly de Sousa Rodrigues Valterlúcio dos Santos Sales Francisco Rodolpho Sobreira Dantas Nóbrega de Figueiredo Izabel Cristina Santiago Lemos Álefe Brito Monteiro Irwin Rose Alencar de Menezes José Galberto Martins da Costa Marta Regina Kerntopf 《Saudi Journal of Biological Sciences》2018,25(4):609-621
Annona muricata Linnaeus, popularly known as “graviola” and also called soursop, is a species typical of countries with a tropical climate, and it is used in folk medicine as an anticancer, analgesic and antispasmodic agent. The aim of the present study was to validate the gastroprotective activity of the hydroalcoholic extract of the leaves of A. muricata (HEAM) and to investigate the underlying mechanisms of action for this effect. Gastric lesions were induced in mice by absolute ethanol, acidified ethanol or indomethacin. Before, the animals were pretreated with saline, omeprazole or HEAM orally at doses of 50–400 mg/kg. To determine the mechanism of action of the extract, we investigated, using specific inhibitors, the involvement of nitric oxide (NO), prostaglandins (PGEs), ATP-dependent K+ channels and α2-noradrenergic receptors. HEAM showed significant antiulcer activity against lesions induced by absolute ethanol, acidified ethanol or indomethacin, which was mediated by endogenous gastric prostaglandins. 相似文献