共查询到20条相似文献,搜索用时 15 毫秒
1.
Background
We study root cells from the model plant Arabidopsis thaliana and the communication channel conformed by the ethylene signal transduction pathway. A basic equation taken from our previous work relates the probability of expression of the gene ERF1 to the concentration of ethylene. 相似文献2.
Background
Rat liver endosomes contain activated insulin receptors and downstream signal transduction molecules. We undertook these studies to determine whether endosomes also contain heterotrimeric G proteins that may be involved in signal transduction from G protein-coupled receptors. 相似文献3.
Background
G protein-coupled receptors (GPCRs) constitute a large family of integral transmembrane receptor proteins that play a central role in signal transduction in eukaryotes. The genome of the protochordate Ciona intestinalis has a compact size with an ancestral complement of many diversified gene families of vertebrates and is a good model system for studying protochordate to vertebrate diversification. An analysis of the Ciona repertoire of GPCRs from a comparative genomic perspective provides insight into the evolutionary origins of the GPCR signalling system in vertebrates. 相似文献4.
Claus A Andersen Stefano Gotta Letizia Magnoni Roberto Raggiaschi Andreas Kremer Georg C Terstappen 《BMC bioinformatics》2009,10(1):141-15
Background
Quantitative measurements of specific protein phosphorylation sites, as presented here, can be used to investigate signal transduction pathways, which is an important aspect of cell dynamics. The presented method quantitatively compares peptide abundances from experiments using 18O/16O labeling starting from elaborated MS spectra. It was originally developed to study signaling cascades activated by amyloid-β treatment of neurons used as a cellular model system with relevance to Alzheimer's disease, but is generally applicable. 相似文献5.
6.
Towards the systematic discovery of signal transduction networks using phosphorylation dynamics data
Haruna Imamura Nozomu Yachie Rintaro Saito Yasushi Ishihama Masaru Tomita 《BMC bioinformatics》2010,11(1):232
Background
Phosphorylation is a ubiquitous and fundamental regulatory mechanism that controls signal transduction in living cells. The number of identified phosphoproteins and their phosphosites is rapidly increasing as a result of recent mass spectrometry-based approaches. 相似文献7.
Francisco J Leyva Joshua J Anzinger J Philip McCoyJr Howard S Kruth 《BMC biotechnology》2011,11(1):13
Background
Monocyte-derived macrophages contribute to atherosclerotic plaque formation. Therefore, manipulating macrophage function could have significant therapeutic value. The objective of this study was to determine transduction efficiency of two HIV-based lentiviral vector configurations as delivery systems for the transduction of primary human blood monocyte-derived macrophages. 相似文献8.
Background
In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway. Whether or not this dependence on the primary cilium is a universal feature of vertebrate Hedgehog signalling has remained contentious due, in part, to the apparent divergence of the intracellular transduction pathway between mammals and teleost fish. 相似文献9.
Dennis YQ Wang Luca Cardelli Andrew Phillips Nir Piterman Jasmin Fisher 《BMC systems biology》2009,3(1):118-17
Background
The epidermal growth factor receptor (EGFR) signaling pathway plays a key role in regulation of cellular growth and development. While highly studied, it is still not fully understood how the signal is orchestrated. One of the reasons for the complexity of this pathway is the extensive network of inter-connected components involved in the signaling. In the aim of identifying critical mechanisms controlling signal transduction we have performed extensive analysis of an executable model of the EGFR pathway using the stochastic pi-calculus as a modeling language. 相似文献10.
Markus Koschorreck Holger Conzelmann Sybille Ebert Michael Ederer Ernst Dieter Gilles 《BMC bioinformatics》2007,8(1):336
Background
Combinatorial complexity is a challenging problem in detailed and mechanistic mathematical modeling of signal transduction. This subject has been discussed intensively and a lot of progress has been made within the last few years. A software tool (BioNetGen) was developed which allows an automatic rule-based set-up of mechanistic model equations. In many cases these models can be reduced by an exact domain-oriented lumping technique. However, the resulting models can still consist of a very large number of differential equations. 相似文献11.
Matthias Schlesner Arthur Miller Stefan Streif Wilfried F Staudinger Judith Müller Beatrix Scheffer Frank Siedler Dieter Oesterhelt 《BMC microbiology》2009,9(1):56
Background
Archaea share with bacteria the ability to bias their movement towards more favorable locations, a process known as taxis. Two molecular systems drive this process: the motility apparatus and the chemotaxis signal transduction system. The first consists of the flagellum, the flagellar motor, and its switch, which allows cells to reverse the rotation of flagella. The second targets the flagellar motor switch in order to modulate the switching frequency in response to external stimuli. While the signal transduction system is conserved throughout archaea and bacteria, the archaeal flagellar apparatus is different from the bacterial one. The proteins constituting the flagellar motor and its switch in archaea have not yet been identified, and the connection between the bacterial-like chemotaxis signal transduction system and the archaeal motility apparatus is unknown. 相似文献12.
Lorella Navazio Barbara Baldan Roberto Moscatiello Anna Zuppini Sheridan L Woo Paola Mariani Matteo Lorito 《BMC plant biology》2007,7(1):41
Background
Calcium is commonly involved as intracellular messenger in the transduction by plants of a wide range of biotic stimuli, including signals from pathogenic and symbiotic fungi. Trichoderma spp. are largely used in the biological control of plant diseases caused by fungal phytopathogens and are able to colonize plant roots. Early molecular events underlying their association with plants are relatively unknown. 相似文献13.
Mohit Raja Jain Shengjie Bian Tong Liu Jun Hu Stella Elkabes Hong Li 《Proteome science》2009,7(1):25-10
Background
Abnormal activation of protease activities during experimental autoimmune encephalomyelitis (EAE) in rats, a rodent model of multiple sclerosis, have been implicated in either the direct destruction of myelin components or the intracellular signal transduction pathways that lead to lymphocyte infiltration, oligodendrocyte destruction, neuronal dysfunctions and axonal degeneration. The identification of changes in regulated proteolytic events during EAE is crucial for uncovering activated proteases that may underline the pathological features such as inflammation and demyelination. We searched for either non-tryptic or semi-tryptic peptides from a previous shotgun proteomics study using isobaric tags for relative and absolute quantification (iTRAQ) to compare the proteomes of normal and EAE rat lumbar spinal cords. 相似文献14.
Dietrich Trümbach Cornelia Graf Benno Pütz Claudia Kühne Marcus Panhuysen Peter Weber Florian Holsboer Wolfgang Wurst Gerhard Welzl Jan M Deussing 《BMC systems biology》2010,4(1):159
Background
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of complex and multifactorial psychiatric diseases such as anxiety and mood disorders. About 50-60% of patients with major depression show HPA axis dysfunction, i.e. hyperactivity and impaired negative feedback regulation. The neuropeptide corticotropin-releasing hormone (CRH) and its receptor type 1 (CRHR1) are key regulators of this neuroendocrine stress axis. Therefore, we analyzed CRH/CRHR1-dependent gene expression data obtained from the pituitary corticotrope cell line AtT-20, a well-established in vitro model for CRHR1-mediated signal transduction. To extract significantly regulated genes from a genome-wide microarray data set and to deduce underlying CRHR1-dependent signaling networks, we combined supervised and unsupervised algorithms. 相似文献15.
Background
A Signal transduction pathway is the chain of processes by which a cell converts an extracellular signal into a response. In most unicellular organisms, the number of signal transduction pathways influences the number of ways the cell can react and respond to the environment. Discovering signal transduction pathways is an arduous problem, even with the use of systematic genomic, proteomic and metabolomic technologies. These techniques lead to an enormous amount of data and how to interpret and process this data becomes a challenging computational problem. 相似文献16.
So-Jung Kwon Kyuyong Han Suhyun Jung Jong-Eun Lee Seongsoon Park Yong-Pil Cheon Jade Hyunjung Lim 《BMC biotechnology》2009,9(1):73
Background
MPG is a cell-permeable peptide with proven efficiency to deliver macromolecular cargoes into cells. In this work, we examined the efficacy of MPG as an N-terminal tag in a fusion protein to deliver a protein cargo and its mechanism of transduction. 相似文献17.
Mariana Conte Silvia de Simone Susan J Simmons Carlos L Ballaré Ann E Stapleton 《BMC plant biology》2010,10(1):112
Background
Understanding of the genetic architecture of plant UV-B responses allows extensive targeted testing of candidate genes or regions, along with combinations of those genes, for placement in metabolic or signal transduction pathways. 相似文献18.
19.
Hong-Juan He Qian Wang Wei-Wei Zheng Jin-Xing Wang Qi-Sheng Song Xiao-Fan Zhao 《BMC cell biology》2010,11(1):1
Background
Nuclear transport factor 2 and small GTPase Ran participate in the nucleo-cytoplasm transport of macromolecules, but their function in the 20-hydroxyecdysone (20E) signal transduction pathway are not well known. 相似文献20.
Jayson Gutiérrez Georges St LaurentIII Silvio Urcuqui-Inchima 《Theoretical biology & medical modelling》2010,7(1):7