Effect of endotoxin on antibody response and resistance to infection in Newborn animals

1. (1)
   В отличие от действия эндотоксина на образование антител у взрослых животных, у молодых животных не наблюдалось стимулирующего влияния эндотоксина (эндотоксины Escherichia coli и Salmonella typhi) на образование антител ни против беикового, ни против бактериального антигенов.     
   
   

Effect of carbon disulphide on the cardiovascular system

Biochemical, histological and electron-microscopic examinations of the heart and the aorta of albino rats exposed to carbon disulphide in concentrations of 10, 50, 100 and 200 mg . m-3 were carried out. Changes in the metabolic and energetic processes in the myocardium and in the quantitative and qualitative characteristics of the connective tissue of the aortal vessel wall were observed. The established disorders follow the dose-effect dependence. The authors studied the effect of carbon disulphide in concentrations of 10 and 50 mg . m-3 on the electrophoretic spectrum of serum proteins, the quantitative and qualitative characteristics of fibrous structures in the myocardium and the aorta of albino rats fed on atherogenic diet (cholesterol, cholic acid and vitamin D2). The combination of carbon disulphide with the atherogenic factor leads to intensification of changes in the cardiovascular system and in serum proteins, observed after independent exposure to either of the factors. The combination of atherogenic diet and 10 mg . m-3 carbon disulphide induced symptoms of intoxication, decreased survival of the animals, and the developing sclerotic process was found to be more severe and to progress more rapidly than in animals subject to atherogenic diet alone. The obtained results testify to cardiovascular effect of carbon disulphide. The observed atherogenic effect of carbon disulphide in low concentrations is most probably connected with its direct effect on the myocardium and the vessels.     

Effect of aurothioglucose on some allergic and non-allergic skin reactions in animals.

The antiphlogistic effect of aurothioglucose was examined in reversed passive Arthus reaction, delayed-type hypersensitivity and carrageenan oedema. A close association existed between the antiphlogistic effect of aurothioglucose and the pathogenetic role of polymorphonuclear leukocytes. In reversed passive Arthus reaction and in carrageenan oedema the drug decreased the inflammation considerably, whereas in delayed hypersensitivity, where the leukocytes play a less important part, it exerted only a mitigating effect.