共查询到20条相似文献,搜索用时 13 毫秒
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Bombesin Receptor‐Activated Protein (BRAP) Modulates NF‐κB Activation in Bronchial Epithelial Cells by Enhancing HDAC Activity 下载免费PDF全文
Ying Liu Xiao‐Qun Qin Horst Christian Weber Yang Xiang Chi Liu Hui‐Jun Liu Huan Yang Jianxin Jiang Xiangping Qu 《Journal of cellular biochemistry》2016,117(5):1069-1077
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Laura Babiarz‐Magee Nannan Chen Miri Seiberg Connie B. Lin 《Pigment cell & melanoma research》2004,17(3):241-251
Skin color results from the production and distribution of melanin in the epidermis. The protease‐activated receptor‐2 (PAR‐2), expressed on keratinocytes but not on melanocytes, is involved in melanosome uptake via phagocytosis, and modulation of PAR‐2 activation affects skin color. The pattern of melanosome distribution within the epidermis is skin color‐dependent. In vitro, this distribution pattern is regulated by the ethnic origin of the keratinocytes, not the melanocytes. Therefore, we hypothesized that PAR‐2 may play a role in the modulation of pigmentation in a skin type‐dependent manner. We examined the expression of PAR‐2 and its activator, trypsin, in human skins with different pigmentary levels. Here we show that PAR‐2 and trypsin are expressed in higher levels, and are differentially localized in highly pigmented, relative to lightly pigmented skins. Moreover, highly pigmented skins exhibit an increase in PAR‐2‐specific protease cleavage ability. Microsphere phagocytosis was more efficient in keratinocytes from highly pigmented skins, and PAR‐2 induced phagocytosis resulted in more efficient microsphere ingestion and more compacted microsphere organization in dark skin‐derived keratinocytes. These results demonstrate that PAR‐2 expression and activity correlate with skin color, suggesting the involvement of PAR‐2 in ethnic skin color phenotypes. 相似文献
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Androgen Receptor Silences Thioredoxin‐interacting Protein and Competitively Inhibits Glucocorticoid Receptor‐Mediated Apoptosis in Pancreatic β‐Cells 下载免费PDF全文
Naoki Harada Takahiro Katsuki Yuji Takahashi Tatsuya Masuda Mariko Yoshinaga Tetsuya Adachi Takeshi Izawa Mitsuru Kuwamura Yoshihisa Nakano Ryoichi Yamaji Hiroshi Inui 《Journal of cellular biochemistry》2015,116(6):998-1006
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Glucose Promotes a Pro‐Oxidant and Pro‐Inflammatory Stromal Microenvironment Which Favors Motile Properties in Breast Tumor Cells 下载免费PDF全文
Violeta Kallens Nicolás Tobar Jessica Molina Arantzazú Bidegain Patricio C. Smith Omar Porras Jorge Martínez 《Journal of cellular biochemistry》2017,118(5):994-1002
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C/EBP‐β Is Differentially Affected by PPARα Agonists Fenofibric Acid and GW7647, But Does Not Change Apolipoprotein A‐I Production During ER‐Stress and Inflammation 下载免费PDF全文
Sophie E. van der Krieken Herman E. Popeijus Maurice Konings Stefan P.J. Dullens Ronald P. Mensink Jogchum Plat 《Journal of cellular biochemistry》2017,118(4):754-763
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Nonivamide Enhances miRNA let‐7d Expression and Decreases Adipogenesis PPARγ Expression in 3T3‐L1 Cells 下载免费PDF全文
Barbara Rohm Ann‐Katrin Holik Nicole Kretschy Mark M. Somoza Jakob P. Ley Sabine Widder Gerhard E. Krammer Doris Marko Veronika Somoza 《Journal of cellular biochemistry》2015,116(6):1153-1163
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Su-Mi Woo Hae-Soon Lim Kyung-Yi Jeong Seon-Mi Kim Won-Jae Kim Ji-Yeon Jung 《Molecules and cells》2015,38(7):604-609
The active metabolite of vitamin D such as 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) is a well-known key regulatory factor in bone metabolism. However, little is known about the potential of vitamin D as an odontogenic inducer in human dental pulp cells (HDPCs) in vitro. The purpose of this study was to evaluate the effect of vitamin D3 metabolite, 1α,25(OH)2D3, on odontoblastic differentiation in HDPCs. HDPCs extracted from maxillary supernumerary incisors and third molars were directly cultured with 1α,25(OH)2D3 in the absence of differentiation-inducing factors. Treatment of HDPCs with 1α,25(OH)2D3 at a concentration of 10 nM or 100 nM significantly upregulated the expression of dentin sialophosphoprotein (DSPP) and dentin matrix protein1 (DMP1), the odontogenesis-related genes. Also, 1α,25(OH)2D3 enhanced the alkaline phosphatase (ALP) activity and mineralization in HDPCs. In addition, 1α,25(OH)2D3 induced activation of extracellular signal-regulated kinases (ERKs), whereas the ERK inhibitor U0126 ameliorated the upregulation of DSPP and DMP1 and reduced the mineralization enhanced by 1α,25(OH)2D3. These results demonstrated that 1α,25(OH)2D3 promoted odontoblastic differentiation of HDPCs via modulating ERK activation. 相似文献
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Human Serum Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells In Vitro and In Vivo
Alessandra Pisciotta Massimo Riccio Gianluca Carnevale Francesca Beretti Lara Gibellini Tullia Maraldi Gian Maria Cavallini Adriano Ferrari Giacomo Bruzzesi Anto De Pol 《PloS one》2012,7(11)
Human dental pulp is a promising alternative source of stem cells for cell-based tissue engineering in regenerative medicine, for the easily recruitment with low invasivity for the patient and for the self-renewal and differentiation potential of cells. So far, in vitro culture of mesenchymal stem cells is usually based on supplementing culture and differentiation media with foetal calf serum (FCS). FCS is known to contain a great quantity of growth factors, and thus to promote cell attachment on plastic surface as well as expansion and differentiation. Nevertheless, FCS as an animal origin supplement may represent a potential means for disease transmission besides leading to a xenogenic immune response. Therefore, a significant interest is focused on investigating alternative supplements, in order to obtain a sufficient cell number for clinical application, avoiding the inconvenients of FCS use. In our study we have demonstrated that human serum (HS) is a suitable alternative to FCS, indeed its addition to culture medium induces a high hDPSCs proliferation rate and improves the in vitro osteogenic differentiation. Furthermore, hDPSCs-collagen constructs, pre-differentiated with HS-medium in vitro for 10 days, when implanted in immunocompromised rats, are able to restore critical size parietal bone defects. Therefore these data indicate that HS is a valid substitute for FCS to culture and differentiate in vitro hDPSCs in order to obtain a successful bone regeneration in vivo. 相似文献
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BRCA1‐Mediated Inflammation and Growth Activated & Inhibited Transition Mechanisms Between No‐Tumor Hepatitis/Cirrhotic Tissues and HCC 下载免费PDF全文
Haizhen Diao Lin Wang Juxiang Huang Minghu Jiang Huilei Zhou Xiaohe Li Qingchun Chen Zhenfu Jiang Haitao Feng 《Journal of cellular biochemistry》2014,115(4):641-650
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Activated α2‐Macroglobulin Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low‐Density Lipoprotein Receptor‐Related Protein 1 下载免费PDF全文
Darío G. Ferrer Virginia Actis Dato Javier R. Jaldín‐Fincati Valeria E. Lorenc María C. Sánchez Gustavo A. Chiabrando 《Journal of cellular biochemistry》2017,118(7):1810-1818
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