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Effect of rMnSOD on Sodium Reabsorption in Renal Proximal Tubule in Ochratoxin A—Treated Rats 下载免费PDF全文
Sara Damiano Maria V. Puzio Caterina Squillacioti Nicola Mirabella Enrica Zona Aldo Mancini Antonella Borrelli Carlo Astarita Silvia Boffo Antonio Giordano Luigi Avallone Salvatore Florio Roberto Ciarcia 《Journal of cellular biochemistry》2018,119(1):424-430
Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium that represent toxic real threat for human beings and animal health. In this study we evaluated the effect of a new recombinant mitochondrial manganese containing superoxide dismutase (rMnSOD) on oxidative stress and on the alterations of fluid reabsorption in renal proximal tubule (PT) as possible causes of OTA nephrotoxicity. Finally, we have measured the concentration of O2? in the kidney through dihydroethidium assay (DHE) and nitric oxide (NO) concentration through nitrites and nitrates assay. Male Sprague Dawley rats weighing 120–150 g were treated for 14 days by gavage, as follows: Control group, 12 rats received a corresponding amount of saline solution (including 10% DMSO); rMnSOD group, 12 rats treated with rMnSOD (10 µg/kg bw); OTA group, 12 rats treated with OTA (0.5 mg/kg bw) dissolved in 10% DMSO and then scaled to required volume with corn oil; rMnSOD + OTA, 12 rats treated with rMnSOD (10 µg/kg bw) plus OTA (0.5 mg/kg bw). Our results have shown that rMnSOD restores the alteration of reabsorption in PT in rats treated with OTA plus rMnSOD, probably through the response to pressure natriuresis, where nitric oxide plays a key role. Moreover, rMnSOD prevents the nephrotoxicity induced by OTA probably restoring the balance between superoxide and NO that is most probably the cause of hypertension and renal functional alterations through the inhibition of NO synthase. In conclusion these data provide important information for understanding of mechanism of toxic action of OTA. J. Cell. Biochem. 119: 424–430, 2018. © 2017 Wiley Periodicals, Inc. 相似文献
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Anti‐Inflammatory and Anti‐Oxidant Effects of p‐Chloro‐phenyl‐selenoesterol on TNBS‐Induced Inflammatory Bowel Disease in Mice 下载免费PDF全文
Micheli Stéfani Zarzecki Vandreza Cardoso Bortolotto Márcia Rósula Poetini Stífani Machado Araujo Mariane Trindade de Paula Silvane Souza Roman Cristiano Spiazzi Franciele Weber Santos Cibin Oscar Endrigo Dorneles Rodrigues Cristiano Ricardo Jesse Marina Prigol 《Journal of cellular biochemistry》2017,118(4):709-717
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Castanea sativa Mill. Bark Extract Protects U‐373 MG Cells and Rat Brain Slices Against Ischemia and Reperfusion Injury 下载免费PDF全文
Chiara Santulli Claudia Brizi Matteo Micucci Ambra Del Genio Assunta De Cristofaro Federica Bracco Giuseppina Lucia Pepe Ilaria di Perna Roberta Budriesi Alberto Chiarini Maria Frosini 《Journal of cellular biochemistry》2017,118(4):839-850
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The Protective Effect of Apocynin on Cyclosporine A‐Induced Hypertension and Nephrotoxicity in Rats 下载免费PDF全文
Roberto Ciarcia Sara Damiano Alessia Florio Manuela Spagnuolo Enza Zacchia Caterina Squillacioti Nicola Mirabella Salvatore Florio Ugo Pagnini Tiziana Garofano Maria Sole Polito Giovambattista Capasso Antonio Giordano 《Journal of cellular biochemistry》2015,116(9):1848-1856
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GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress‐Induced Apoptosis 下载免费PDF全文
Manish K. Gupta Farzaneh G. Tahrir Tijana Knezevic Martyn K. White Jennifer Gordon Joseph Y. Cheung Kamel Khalili Arthur M. Feldman 《Journal of cellular biochemistry》2016,117(8):1813-1821
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