共查询到20条相似文献,搜索用时 248 毫秒
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Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta 总被引:2,自引:0,他引:2
Tan L Peng H Osaki M Choy BK Auron PE Sandell LJ Goldring MB 《The Journal of biological chemistry》2003,278(20):17688-17700
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ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation 总被引:2,自引:0,他引:2
Brown C Gaspar J Pettit A Lee R Gu X Wang H Manning C Voland C Goldring SR Goldring MB Libermann TA Gravallese EM Oettgen P 《The Journal of biological chemistry》2004,279(13):12794-12803
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Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1. 总被引:14,自引:0,他引:14
M Oikawa M Abe H Kurosawa W Hida K Shirato Y Sato 《Biochemical and biophysical research communications》2001,289(1):39-43
ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated inducibility. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1. 相似文献
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Suzuki Y Miura H Tanemura A Kobayashi K Kondoh G Sano S Ozawa K Inui S Nakata A Takagi T Tohyama M Yoshikawa K Itami S 《FEBS letters》2002,518(1-3):67-71
We have designed a chimeric promoter that can be stimulated by various pro-inflammatory mediators and so drive the expression of therapeutic genes under inflammatory conditions. The promoter has two parts, the [-247/+20] fragment of the human type IIA secreted phospholipase A2 gene promoter, which is stimulated by the pro-inflammatory cytokine interleukin-1beta (IL-1beta), and a double peroxisome proliferator-activated receptor response element that is activated by some eicosanoids and by non-steroidal anti-inflammatory drugs (NSAIDs). Transfection experiments using rabbit articular chondrocytes in primary culture showed that this chimeric promoter produced a low basal activity and was induced by NSAIDs, WY-14643, IL-1beta, and 15-deoxy Delta12,14 prostaglandin J2. The latter two compounds stimulated the promoter synergistically. 相似文献
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ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene 总被引:1,自引:0,他引:1
Rudders S Gaspar J Madore R Voland C Grall F Patel A Pellacani A Perrella MA Libermann TA Oettgen P 《The Journal of biological chemistry》2001,276(5):3302-3309
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